Method For Identifying At Risk Cardiovascular Disease Patients

Abstract

The invention provides a data base of LDL, I, IIa, IIb, IIIa, IIb, IVa, IVb and HDL2a, HDL2b, HDL 3a, HDL 3b and HDL 3c together with patient data such as HDL-C, LDL-C, Apo A, ApoB, Lp(a) and patient personal data useful for treatment, diagnosing, and monitoring cardiovascular disease. The data base contains the LDL and HDL subfraction data in quantitative mg/dl values and permits deriving relationship amongst the LDL and HDL values and cardiovascular disease. Quantitative data permits more effective treatment and monitoring of cardiovascular disease. For example, quantitative differences in LDL and HDL subclass levels can determine the need for more or less aggressive treatment. The data base which includes patient events, procedures, interventions which is correlated to LDL and HDl quantitative subclass data permits development of personalized patient treatment plans and monitoring the effectiveness of such treatment. Thus, LDL and HDL quantitative subfraction data can be used to more effectively treat and monitor cardiovascular disease. The invention, for example, provides a method for identifying patients with normal NCEP lipid levels who are in need of treatment for cardiovascular disease comprising measuring one or more LDL or HDL particle subclass levels and identifying abnormal LDL or HDL subclass levels. LDL III a & b and HDL 2b are preferred subclasses.

1 .- 17 . (canceled) 
   
   
       18 . A method for identifying patients who will need multiple invasive cardiovascular procedures comprising determining the elevated LDL IVb levels. 
   
   
       19 . The method of  claim 18  wherein the LDL value is in mg/dL. 
   
   
       20 . The method of  claim 18  wherein the elevated level of LDL IVb is a level above 10% of the LDL particles. 
   
   
       21 . The method of  claim 18  wherein the LDL subclass are determined by linear gel electrophoresis, segmented gradient gel electrophoresis, analytical ultracentrifugation, NMR, or ion mobility analysis. 
   
   
       22 . The method of  claim 18  wherein the LDL IVb subclass is measured by segmented gradient gel electrophoresis. 
   
   
       23 . A data base which contains data for LDL and HDL subclasses in mg/dL and data for cardiovascular disease patients. 
   
   
       24 . A data base which contains data for selected LDL and HDL subclasses in mg/mL which is correlated to cardiovascular disease. 
   
   
       25 . The data base of  claim 24  wherein LDL IVb is in mg/dL. 
   
   
       26 . The data base of  claim 24  wherein HDL 2b is in mg/dL. 
   
   
       27 . The data base of  claim 24  wherein LDL III a+b is in mg/dL.