Inhibitors of nitric oxide synthase

Abstract

The current invention discloses novel methods for the inhibition of inducible nitric oxide synthesis (iNOS) and the production of NO. Methods of inhibiting the induction of proinflammatory cytokines are also described. Methods of treating various disease states, such as X-linked adrenoleukodystrophy, multiple sclerosis, Alzheimer's and septic shock using inhibitors of iNOS and cytokine induction are disclosed. The inhibitors include the exemplary compounds lovastatin, a sodium salt of phenylacetic acid (NaPA), FPT inhibitor II, N-acetyl cysteine (NAC), and cAMP.

1 - 71 . (canceled) 
     
     
         72 . A method for enhancing the production of an inducible nitric oxide synthatase or a proinflammatory cytokine in a cell comprising providing a biologically effective amount of a inducible nitric oxide synthatase stimulator, wherein said stimulator is a PKA inhibitor or enhancer of intracellular cAMP. 
     
     
         73 . The method of  claim 72 , wherein said PKA inhibitor is H-89, myristoylated PKI or (R)-cAMP. 
     
     
         74 . The method of  claim 72 , wherein said enhancer of intracellular cAMP is forskolin, 8-bromo-cAMP, and rolipram. 
     
     
         75 . The method of  claim 72 , wherein said enhancer of intracellular cAMP is an inhibitor of cAMP phosphodiesterase.