Ethylene glycol esters as photoactive agents

Abstract

New compounds useful in photodynamic therapy are of the formula and their 1,4-diene isomers and the metallated and/or labeled and/or conjugated forms thereof wherein each R 1 is independently alkyl (1-6C); each n is independently an integer of 0-6; and R 2 is vinyl or a derivative form thereof.

1 . An improved method to conduct photodynamic therapy for immunomodulating an immune response mediated by an activated macrophage in a subject wherein said method comprises administering a photoactive compound to a subject in need of said therapy and irradiating said subject with light wherein said photoactive compound is a compound of the formula 
     
       
         
         
             
             
         
       
       and their 1,4-diene isomers 
       and the metallated and/or labeled and/or conjugated forms thereof
 wherein each R 1  is independently alkyl (1-6C); 
 each n is independently an integer of 0-6; and 
 R 2  is vinyl or a derivative form thereof. 
 
     
   
   
       2 . The method of  claim 1  wherein said photoactive compound is a compound of the formula 
     
       
         
         
             
             
         
       
       and the metallated and/or labeled and/or conjugated forms thereof. 
     
   
   
       3 . The method of  claim 1  wherein said photoactive compound is a compound of the formula 
     
       
         
         
             
             
         
       
       which is in a metallated form. 
     
   
   
       4 . The method of  claim 1  wherein said photoactive compound is a compound of the formula 
     
       
         
         
             
             
         
       
       which is in conjugated form. 
     
   
   
       5 . The method of  claim 1  wherein said photoactive compound is a compound of the formula 
     
       
         
         
             
             
         
       
       which is labeled. 
     
   
   
       6 . The method of  claim 1  wherein said photoactive compound is a compound of the formula 
     
       
         
         
             
             
         
       
       which does not contain a metal ion. 
     
   
   
       7 . The method of  claim 1  wherein said compound is in a metallated form. 
   
   
       8 . The method of  claim 1  wherein said compound is in a conjugated form. 
   
   
       9 . The method of  claim 1  wherein said compound is labeled. 
   
   
       10 . The method of  claim 1  wherein said compound does not contain a metal ion. 
   
   
       11 . The method of  claim 1  wherein each R 1  is methyl. 
   
   
       12 . The method of  claim 1  wherein both n are 2. 
   
   
       13 . The method of  claim 1  wherein R 2  is vinyl and both R 1  are methyl. 
   
   
       14 . The method of  claim 1  wherein said compound is in a pharmaceutical composition with at least one pharmaceutically acceptable excipient. 
   
   
       15 . The method of  claim 2  wherein said compound is in a pharmaceutical composition with at least one pharmaceutically acceptable excipient. 
   
   
       16 . The method of  claim 3  wherein said compound is in a pharmaceutical composition with at least one pharmaceutically acceptable excipient. 
   
   
       17 . The method of  claim 4  wherein said compound is in a pharmaceutical composition with at least one pharmaceutically acceptable excipient. 
   
   
       18 . The method of  claim 5  wherein said compound is in a pharmaceutical composition with at least one pharmaceutically acceptable excipient. 
   
   
       19 . The method of  claim 6  wherein said compound is in a pharmaceutical composition with at least one pharmaceutically acceptable excipient.