Method for administering a therapeutic agent into tissue

Abstract

An apparatus for administering a therapeutic agent is provided. The apparatus, in an embodiment, includes an ozone generator connected to a scavenger and an ozone administrator via network of tubing and valves. When activated and the valves placed in the proper position, the ozone generator will fill the ozone administrator with ozone. The ozone generator can then be turned off and the valves moved so that the administrator can be disconnected from the remainder of the apparatus. The administrator is typically in the form of a syringe and needle. Once the syringe and needle is filled with ozone, the needle can be inserted into a tissue and the ozone expressed therefrom into the tissue. Various other apparatuses and methods are also contemplated.

1 . A method of treating pain, comprising: identifying a pain site and injecting medical ozone into the pain site. 
   
   
       2 . The method of  claim 1 , wherein injecting medical ozone comprises utilizing an apparatus for the self-contained generation and administration of medical ozone. 
   
   
       3 . The method of  claim 2 , wherein the apparatus comprises:
 a chamber for holding said agent;   a catheter for connecting said chamber to an area for administration of said agent;   a power supply;   a therapeutic agent generator in communication with said chamber, said generator connected to said power supply; and   a switch in operable communication with said power supply such that when said switch is activated said therapeutic agent generator generates said therapeutic agent.   
   
   
       4 . The method of  claim 2 , wherein said medical ozone comprises a ratio of ozone (O 3 ) to oxygen (O 2 ). 
   
   
       5 . The method of  claim 4 , wherein said ratio of ozone to oxygen is about 1 μg/ml. 
   
   
       6 . The method of  claim 4 , wherein said ratio of ozone to oxygen is about 10 μg/ml. 
   
   
       7 . The method of  claim 4 , wherein said ratio of ozone to oxygen is about 20 μg/ml. 
   
   
       8 . The method of  claim 4 , wherein said ratio of ozone to oxygen is about 30 μg/ml. 
   
   
       9 . The method of  claim 4 , wherein said ratio of ozone to oxygen is about 40 μg/ml. 
   
   
       10 . The method of  claim 4 , wherein said ratio of ozone to oxygen is about 50 μg/ml. 
   
   
       11 . The method of  claim 4 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 1 μg/ml and about 90 μg/ml. 
   
   
       12 . The method of  claim 11 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μg/ml and about 80 μg/ml. 
   
   
       13 . The method of  claim 12 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 20 μg/ml and about 70 μg/ml. 
   
   
       14 . The method of  claim 13 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μg/ml and about 34 μg/ml. 
   
   
       15 . The method of  claim 14 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 27 μg/ml to about 28 μg/ml. 
   
   
       16 . A method of treating pain, comprising:
 activating an ozone generator external to the patient;   creating a specific concentration of O3/O2 gas mixture on the ozone generator;   aspirating the O3/O2 gas mixture into the syringe; and   injecting a predetermined volume of a fixed concentration of ozone/oxygen gas mixture into the pain site.   
   
   
       17 . The method of  claim 16 , wherein injecting medical ozone comprises utilizing an apparatus for the self-contained generation and administration of medical ozone. 
   
   
       18 . The method of  claim 17 , wherein the apparatus comprises:
 a chamber for holding said agent;   a catheter for connecting said chamber to an area for administration of said agent;   a power supply;   a therapeutic agent generator in communication with said chamber, said generator connected to said power supply; and   a switch in operable communication with said power supply such that when said switch is activated said therapeutic agent generator generates said therapeutic agent.   
   
   
       19 . The method of  claim 17 , wherein said medical ozone comprises a ratio of ozone (O 3 ) to oxygen (O 2 ). 
   
   
       20 . The method of  claim 19 , wherein said ratio of ozone to oxygen is about 1 μg/ml. 
   
   
       21 . The method of  claim 19 , wherein said ratio of ozone to oxygen is about 10 μg/ml. 
   
   
       22 . The method of  claim 19 , wherein said ratio of ozone to oxygen is about 20 μg/ml. 
   
   
       23 . The method of  claim 19 , wherein said ratio of ozone to oxygen is about 30 μg/ml. 
   
   
       24 . The method of  claim 19 , wherein said ratio of ozone to oxygen is about 40 μg/ml. 
   
   
       25 . The method of  claim 19 , wherein said ratio of ozone to oxygen is about 50 μg/ml. 
   
   
       26 . The method of  claim 19 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 1 μg/ml and about 90 μg/ml. 
   
   
       27 . The method of  claim 26 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μg/ml and about 80 μg/ml. 
   
   
       28 . The method of  claim 27 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 20 μg/ml and about 70 μg/ml. 
   
   
       29 . The method of  claim 28 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μg/ml and about 34 μg/ml. 
   
   
       30 . The method of  claim 29 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 27 μg/ml to about 28 μg/ml. 
   
   
       31 . The method of  claim 16 , further comprising capturing unused ozone in a scavenger. 
   
   
       32 . A method of treating pain, comprising:
 identifying the pain site with an imaging device;   inserting a needle at or near the pain site;   injecting nonionic x-ray dye through the needle into the area or the pain site;   performing a discogram of the pain site;   activating an ozone generator external to the patient;   selecting a specific concentration of O3/O2 gas mixture on the ozone generator;   attaching a scavenger and a syringe to the ozone generator;   aspirating the O3/O2 gas mixture into the syringe;   injecting a predetermined volume of a fixed concentration of ozone/oxygen gas mixture into the pain site;   capturing unused ozone in the charcoal scavenger; and,   removing all needles.   
   
   
       33 . The method of  claim 32 , wherein injecting medical ozone comprises utilizing an apparatus for the self-contained generation and administration of medical ozone. 
   
   
       34 . The method of  claim 33 , wherein the apparatus comprises:
 a chamber for holding said agent;   a catheter for connecting said chamber to an area for administration of said agent;   a power supply;   a therapeutic agent generator in communication with said chamber, said generator connected to said power supply; and   a switch in operable communication with said power supply such that when said switch is activated said therapeutic agent generator generates said therapeutic agent.   
   
   
       35 . The method of  claim 33 , wherein said medical ozone comprises a ratio of ozone (O 3 ) to oxygen (O 2 ). 
   
   
       36 . The method of  claim 35 , wherein said ratio of ozone to oxygen is about 1 μg/ml. 
   
   
       37 . The method of  claim 35 , wherein said ratio of ozone to oxygen is about 10 μg/ml. 
   
   
       38 . The method of  claim 35 , wherein said ratio of ozone to oxygen is about 20 μg/ml. 
   
   
       39 . The method of  claim 35 , wherein said ratio of ozone to oxygen is about 30 μg/ml. 
   
   
       40 . The method of  claim 35 , wherein said ratio of ozone to oxygen is about 40 μg/ml. 
   
   
       41 . The method of  claim 35 , wherein said ratio of ozone to oxygen is about 50 μg/ml. 
   
   
       42 . The method of  claim 35 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 1 μg/ml and about 90 μg/ml. 
   
   
       43 . The method of  claim 42 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μg/ml and about 80 μg/ml. 
   
   
       44 . The method of  claim 43 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 20 μg/ml and about 70 μg/ml. 
   
   
       45 . The method of  claim 44 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μg/ml and about 34 μg/ml. 
   
   
       46 . The method of  claim 45 , wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 27 μg/ml to about 28 μg/ml.