Cyclic amidine derivatives

Abstract

A cyclic amidine derivative represented by the formula: [wherein R 1 , R 2 and R 3 represent hydrogen, C 1-6 alkyl, aryl-C 1-6 alkyl, etc.; R 4 , R 5 and R 7 represent hydrogen, C 1-6 alkyl, etc.; Z represents 0 or 1; R 6 represents hydrogen, C 1-6 alkyl, C 1-6 alkyloxycarbonyl, etc.; n represents 1 or 2; Y 1 represents a single bond, —CH 2 —, etc.; Y 2 represents a single bond, —CO—, etc.; Ar represents hydrogen, a group represented by the formula: [wherein R 10 -R 14 represent hydrogen, C 1-6 alkyl, hydroxyl, C 1-6 alkoxy, etc., and R 11 and R 12 or R 12 and R 13 may bond together to form a 5- to 8-membered heterocycle], etc.] or a salt thereof.

1 . A compound represented by the formula: 
     
       
         
         
             
             
         
       
       wherein R 1 , R 2 , R 3 , R 4 , R 5  and R 7  are the same or different and each represents hydrogen, cyano, halogen or a group selected from Substituent Group A; 
       z represents 0 or 1 
       R 4  and R 5  may bond together to form a single bond; 
       R 6  represents hydrogen, C 1-6  alkyl, acyl, carbamoyl, hydroxyl, C 1-6  alkoxy, C 1-6  alkyloxycarbonyloxy, C 3-8  cycloalkyl, C 1-6  alkyloxycarbonyl optionally substituted with acyloxy or a C 6-14  aromatic hydrocarbon ring group or a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group E; 
       n represents an integer of 1 or 2; 
       Y 1  represents a single bond, —(CH 2 ) m —, —CR 8 —, —CR 8 CR 9 —, —CH 2 CO—, —NR 8 —, —SO—, —SO 2 —, —CO—, —CONR 8 — or —SO 2 NR 8 —, [wherein m represents an integer of 1 to 3, and R 8  and R 9  are the same or different and each represents hydrogen, halogen, C 1-6  alkyl, carboxyl or C 1-6  alkoxycarbonyl; 
       Y 2  represents a single bond, O, N, —(CH 2 ) m —, —CR 8 —, CR 8 R 9 —, —CO—, —SO—, —SO 2 — or —C(═N—OR 8 )—, wherein m represents an integer of 1 to 3, and R 8  and R 9  are the same of different and each represents hydrogen, halogen, C 1-6  alkyl, carboxyl or C 1-6  alkoxycarbonyl; 
       Ar represents (1) hydrogen, (2) a group represented by the formula: 
     
     
       
         
         
             
             
         
       
       wherein R 10 , R 11 , R 12 , R 13  and R 14  are the same or different and each independently represents hydrogen, cyano, halogen, nitro or a group selected from Substituent Group B, and R 11  and R 12  or R 12  and R 13  may bond together to form a 5- to 8-membered heterocycle optionally having 1 to 4 hetero atoms selected from N, S and O and optionally substituted with at least one group selected from Substituent Group F, or (3) a 5- to 14-membered aromatic heterocyclic group optionally substituted with at least one group selected from Substituent Group G; 
       Substituent Group A represents moieties selected from the group consisting of C 1-6  alkyl, alkylidene, C 2-6  alkenyl, C 2-6  alkynyl, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, sulfonylamino, sulfonyl, sulfamoyl, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group A′; 
       Substituent Group A′ represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl, halogen, C 3-8  cycloalkyl, a heterocyclic alkyl group, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, wherein the C 6-14  aromatic hydrocarbon ring group and the 5- to 14-membered aromatic heterocyclic group may be substituted with at least one group selected from the group consisting of C 1-6  alkyl, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, nitro, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl, halogen and C 3-8  cycloalkyl; 
       Substituent Group B represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, C 1-6  aminoalkyl, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, sulfonylamino, sulfonyl, sulfamoyl, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group B′; 
       Substituent Group B′ represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, oxo, cyano, C 1-6  cyanoacyl, C 2-7  acyl, C 1-6  alkanoyl, benzoyl, aralkanoyl, C 1-6  alkoxyalkylcarbonyl, C 1-6  hydroxyalkylcarbonyl, carboxyl, C 1-6  carboxyalkyl, C 1-6  carboxyalkyloxy, carbamoyl, carbamoylalkyloxy, C 1-6  alkoxycarbonyl, C 1-10  alkoxycarbonyl-C 1-6  alkyl, C 1-10  alkoxycarbonyl-C 1-6  alkyloxy, C 1-6  monoalkylaminocarbonyl, C 2-6  dialkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 1-10  alkoxyalkyl, C 1-10  aralkyloxyalkyl, C 1-6  hydroxyalkyl, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, C 1-6  alkylsulfonylamino, phenylsulfonylamino, C 1-6  alkylsulfonyl, phenylsulfonyl, C 1-6  monoalkylaminosulfonyl, C 2-6  dialkylaminosulfonyl, sulfamoyl, halogeno, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group, a 5- to 14-membered aromatic heterocyclic group, a heterocyclic aminocarbonyl group, a heterocyclic aminosulfonyl group and isoxazolinyl, wherein the 5- to 14-membered non-aromatic heterocyclic group, the C 6-14  aromatic hydrocarbon ring group, the 5- to 14-membered aromatic heterocyclic group and isoxazolinyl may be independently substituted with at least one group selected from the group consisting of C 1-6  alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, nitro, amino, C 1-6  aminoalkyl, C 1-6  alkylamino, C 1-6  dialkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, alkylsulfonylamino, alkylsulfonyl, sulfamoyl, halogeno and C 3-8  cycloalkyl; 
       Substituent Group E represents moieties selected from the group consisting of C 1-6  alkyl, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl, halogen and C 3-8  cycloalkyl; 
       Substituent Group F represents moieties selected from the group consisting of hydrogen, cyano, halogen, oxo and C 1-6  alkyl, alkenyl, alkynyl, acyl, C 1-6  alkanoyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, imino, C 1-6  aminoalkyl, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, sulfonylamino, sulfonyl, sulfamoyl, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group F′; 
       Substituent Group F′ represents moieties selected from the group consisting of C 1-6  alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, benzyloxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, C 1-6  alkylsulfonylamino, C 1-6  alkylsulfonyl, sulfamoyl, halogeno, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group; and 
       Substituent Group G represents moieties selected from the group consisting of C 1-6  alkyl, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, sulfonyl, sulfamoyl, halogeno and C 3-8  cycloalkyl; 
       or a salt thereof. 
     
   
   
       2 . The compound according to  claim 1  or salt thereof,
 wherein R 1 , R 2  and R 3  are the same or different and each represents a group selected from the group consisting of hydrogen, C 1-6  alkyl, C 1-6  alkoxy, aryl-C 1-6  alkyl and aryl-C 1-6  alkylidene;   R 4 , R 5  and R 7  are the same or different and each represents a group selected from the group consisting of hydrogen, C 1-6  alkyl and hydroxyl;   z represents 0 or 1;   R 4  and R 5  may bond together to form a single bond;   R 6  represents a group selected from the group consisting of hydrogen, C 1-6  alkyl and C 1-6  alkyloxycarbonyl optionally substituted with acyloxy;   n represents 1;   Y 1  represents a single bond or —(CH 2 ) m , wherein m represents an integer of 1 to 3;   Y 2  represents a single bond or —CO—;   Ar represents hydrogen or a group represented by the formula:   
     
       
         
         
             
             
         
       
       wherein R 10 , R 11 , R 12 , R 13  and R 14  are the same or different and each represents a group selected from the group consisting of hydrogen, C 1-6  alkyl, hydroxyl, C 1-6  alkoxy, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, a 5- to 14-membered non-aromatic heterocyclic group and C 1-6  alkyloxycarbonyloxy; 
       R 11  and R 12  or R 12  and R 13  may bond together to form a 5- to 8-membered heterocycle (i) optionally having 1 to 4 hetero atoms selected from N, S and O and (ii) optionally substituted with at least one group selected from the group consisting of cyano, oxo, and C 1-6  alkyl, acyl, C 1-6  alkanoyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, sulfonyl and a 5- to 14-membered non-aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group F″; and 
       Substituent Group F″ represents moieties selected from the group consisting of C 1-6  alkyl, oxo, cyano, acyl, carboxyl and C 1-6  alkoxy. 
     
   
   
       3 . The compound according to  claim 1  or a salt thereof, wherein Y 1  is —CH 2 —. 
   
   
       4 . The compound according to  claim 1  or a salt thereof, wherein Y 2  is —CO—. 
   
   
       5 . The compound according to  claim 1  or a salt thereof, wherein Y 1  is —CH 2 — and Y 2  is —CO—. 
   
   
       6 . The compound according to  claim 1  or a salt thereof, wherein Y 1  is a single bond, Y 2  is a single bond and Ar is hydrogen. 
   
   
       7 . The compound according to  claim 1  or a salt thereof, wherein Ar is a group represented by the formula: 
     
       
         
         
             
             
         
       
     
     . 
   
   
       8 . The compound according to  claim 7  or a salt thereof, wherein R 10  and R 14  are hydrogen. 
   
   
       9 . The compound according to  claim 1  or a salt thereof, wherein Ar is a group represented by the formula: 
     
       
         
         
             
             
         
       
       or a 5- to 14-membered aromatic heterocyclic group optionally substituted with at least one group selected from Substituent Group G. 
     
   
   
       10 . The compound according to  claim 9  or a salt thereof, wherein R 10  and R 14  are hydrogen. 
   
   
       11 . A compound represented by the formula: 
     
       
         
         
             
             
         
       
       wherein R 1 , R 2 , R 3 , R 4 , R 5  and R 7  are the same or different and each represents hydrogen, cyano, halogen or a group selected from Substituent Group A; 
       z represents 0 or 1; 
       R 4  and R 5  may bond together to form a single bond; 
       R 6  represents hydrogen, C 1-6  alkyl, acyl, carbamoyl, hydroxyl, C 1-6  alkoxy, C 1-6  alkyloxycarbonyloxy, C 3-8  cycloalkyl, C 1-6  alkyloxycarbonyl optionally substituted with acyloxy or a C 6-14  aromatic hydrocarbon ring group or a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group E; 
       n represents an integer of 1 or 2; 
       Y 1  represents a single bond, —(CH 2 ) m —, —CR 8 —, —CR 8 CR 9 —, —CH 2 CO—, —NR 8 —, —SO—, —SO 2 —, —CO—, —CONR 8 — or —SO 2 NR 8 —, wherein m represents an integer of 1 to 3, and R 8  and R 9  are the same or different and each represents hydrogen, halogen, C 1-6  alkyl, carboxyl or C 1-6  alkoxycarbonyl; 
       Y 2  represents a single bond, O, N, —(CH 2 ) m —, —CR 8 —, CR 8 R 9 —, —CO—, —SO—, —SO 2 — or —C(═N—OR 8 )—, wherein m represents an integer of 1 to 3, and R 8  and R 9  are the same or different and each represents hydrogen, halogen, C 1-6  alkyl, carboxyl or C 1-6  alkoxycarbonyl; 
       Ar is a group represented by the formula: 
     
     
       
         
         
             
             
         
       
       wherein R 11  and R 13  are the same or different and each represents hydrogen, cyano, halogen, nitro or a group selected from Substituent Group B, and 
       R 15  represents hydrogen or a group selected from Substituent Group H, wherein R 11  and R 15  may bond together to form a 5- to 8-membered heterocycle optionally substituted with at least one group selected from Substituent Group F and optionally having 1 or 2 hetero atoms selected from N, S and O; 
       Substituent Group A represents moieties selected from the group consisting of C 1-6  alkyl, alkylidene, C 2-6  alkenyl, C 2-6  alkynyl, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, sulfonylamino, sulfonyl, sulfamoyl, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group A′; 
       Substituent Group A′ represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, cyano, acyl, carboxyl, carbamoyl C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl, halogen, C 3-8  cycloalkyl, a heterocyclic alkyl group, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, wherein the C 6-14  aromatic hydrocarbon ring group and the 5- to 14-membered aromatic heterocyclic group may be substituted with at least one group selected from the group consisting of C 1-6  alkyl, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, nitro, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl, halogen and C 3-8  cycloalkyl; 
       Substituent Group B represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, C 1-6  aminoalkyl, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, sulfonylamino, sulfonyl, sulfamoyl, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group B′; 
       Substituent Group B′ represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, oxo, cyano, C 1-6  cyanoacyl, C 2-7  acyl, C 1-6  alkanoyl, benzoyl, aralkanoyl, C 1-6  alkoxyalkylcarbonyl, C 1-6  hydroxyalkylcarbonyl, carboxyl, C 1-6  carboxyalkyl, C 1-6  carboxyalkyloxy, carbamoyl, carbamoylalkyloxy, C 1-6  alkoxycarbonyl, C 1-10  alkoxycarbonyl-C 1-6  alkyl, C 1-10  alkoxycarbonyl-C 1-6  alkyloxy, C 1-6  monoalkylaminocarbonyl, C 2-6  dialkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 1-10  alkoxyalkyl, C 1-10  aralkyloxyalkyl, C 1-6  hydroxyalkyl, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, C 1-6  alkylsulfonylamino, phenylsulfonylamino, C 1-6  alkylsulfonyl, phenylsulfonyl, C 1-6  monoalkylaminosulfonyl, C 2-6  dialkylaminosulfonyl, sulfamoyl, halogeno, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group, a 5- to 14-membered aromatic heterocyclic group, a heterocyclic aminocarbonyl group, a heterocyclic aminosulfonyl group and isoxazolinyl, wherein the 5- to 14-membered non-aromatic heterocyclic group, the C 6-14  aromatic hydrocarbon ring group, the 5- to 14-membered aromatic heterocyclic group and isoxazolinyl may be independently substituted with at least one group selected from the group consisting of C 1-6  alkyl, oxo, cyano, acyl, carboxyl, carbamoyl C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, nitro, amino, C 1-6  aminoalkyl, C 1-6  alkylamino, C 1-6  dialkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, alkylsulfonylamino, alkylsulfonyl, sulfamoyl, halogeno and C 3-8  cycloalkyl; 
       Substituent Group E represents moieties selected form the group consisting of C 1-6  alkyl, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, sulfonylamino, sulfonyl, sulfamoyl, halogen and C 3-8  cycloalkyl; 
       Substituent Group F represents moieties selected from the group consisting of hydrogen, cyano, halogen, oxo and C 1-6  alkyl, alkenyl, alkynyl, acyl, C 1-6  alkanoyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, imino, C 1-6  aminoalkyl, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, sulfonylamino, sulfonyl, sulfamoyl, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group F′; 
       Substituent Group F′ represents moieties selected form the group consisting of C 1-6  alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, benzyloxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, C 1-6  alkylsulfonylamino, C 1-6  alkylsulfonyl, sulfamoyl, halogeno, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group; 
       Substituent Group H represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, acyl, C 1-6  alkoxycarbonyl, aminocarbonyl, C 1-6  alkylaminocarbonyl, C 3-8  cycloalkyl, C 1-6  aminoalkyl, sulfonyl, C 3-8  cycloalkylamino, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group H′; 
       Substituent Group H′ represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, oxo, cyano, C 1-6  cyanoalkyl, C 2-7  acyl, C 1-6  alkanoyl, benzoyl, aralkanoyl, C 1-6  alkoxyalkylcarbonyl, C 1-6  hydroxyalkylcarbonyl, carboxyl, C 1-6  carboxyalkyl, C 1-6  carboxyalkyloxy, carbamoyl, carbamoylalkyloxy, C 1-6  alkoxycarbonyl, C 1-10  alkoxycarbonyl-C 1-6  alkyl, C 1-10  alkoxycarbonyl-C 1-6  alkyloxy, C 1-6  monoalkylaminocarbonyl, C 2-6  dialkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 1-10  alkoxyalkyl, C 1-10  aralkyloxyalkyl, C 1-6  hydroxyalkyl, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, C 1-6  alkylsulfonylamino, phenylsulfonylamino, C 1-6  alkylsulfonyl, phenylsulfonyl, C 1-6  monoalkylaminosulfonyl, C 2-6  dialkylaminosulfonyl, sulfamoyl, halogeno, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group, a 5- to 14-membered aromatic heterocyclic group, a heterocyclic aminocarbonyl group, a heterocyclic aminosulfonyl group and isoxazolinyl, wherein the 5- to 14-membered non-aromatic heterocyclic group, the C 6-14  aromatic hydrocarbon ring group, the 5- to 14-membered aromatic heterocyclic group and isoxazolinyl may be independently substituted with at least one group selected from the group consisting of C 1-6  alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, nitro, amino, C 1-6  aminoalkyl, C 1-6  alkylamino, C 1-6  dialkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, alkylsulfonylamino, alkylsulfonyl, sulfamoyl, halogeno and C 3-8  cycloalkyl; 
       or a salt thereof. 
     
   
   
       12 . The compound according to  claim 1  or a salt thereof, wherein Ar is a group represented by the formula: 
     
       
         
         
             
             
         
       
       wherein R 11  represents hydrogen, cyano, halogen, nitro or a group selected from Substituent Group B; 
       R 15  represents hydrogen or a group selected from Substituent Group H; 
       R 16  represents hydrogen or a group selected from Substituent Group H; or 
       R 11  and R 15  or R 15  and R 16  may bond together to form a 5- to 6-membered heterocycle optionally substituted with at least one group selected from Substituent Group F and optionally having 1 or 2 hetero atoms selected from N, S and O; 
       Substituent Group F represents moieties selected from the group consisting of hydrogen, cyano, halogen, oxo and C 1-6  alkyl, alkenyl, alkynyl, acyl, C 1-6  alkanoyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, imino, C 1-6  aminoalkyl, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, sulfonylamino, sulfonyl, sulfamoyl, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group F′; 
       Substituent Group F′ represents moieties selected form the group consisting of C 1-6  alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, benzyloxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, C 1-6  alkylsulfonylamino, C 1-6  alkylsulfonyl, sulfamoyl, halogeno, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group; 
       Substituent Group H represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, acyl, C 1-6  alkoxycarbonyl, aminocarbonyl, C 1-6  alkylaminocarbonyl, C 3-8  cycloalkyl, C 1-6  aminoalkyl, sulfonyl, C 3-8  cycloalkylamino, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group H′; and 
       Substituent Group H′ represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, oxo, cyano, C 1-6  cyanoalkyl, C 2-7  acyl C 1-6  alkanoyl, benzoyl, aralkanoyl, C 1-6  alkoxyalkylcarbonyl, C 1-6  hydroxyalkylcarbonyl, carboxyl, C 1-6  carboxyalkyl, C 1-6  carboxyalkyloxy, carbamoyl, carbamoylalkyloxy, C 1-6  alkoxycarbonyl, C 1-10  alkoxycarbonyl-C 1-6  alkyl, C 1-10  alkoxycarbonyl-C 1-6  alkyloxy, C 1-6  monoalkylaminocarbonyl, C 2-6  dialkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 1-10  alkoxyalkyl, C 1-10  aralkyloxyalkyl, C 1-6  hydroxyalkyl, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, C 1-6  alkylsulfonylamino, phenylsulfonylamino, C 1-6  alkylsulfonyl, phenylsulfonyl, C 1-6  monoalkylaminosulfonyl, C 2-6  dialkylaminosulfonyl, sulfamoyl, halogeno, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group, a 5- to 14-membered aromatic heterocyclic group, a heterocyclic aminocarbonyl group, a heterocyclic aminosulfonyl group and isoxazolinyl, wherein the 5- to 14-membered non-aromatic heterocyclic group, the C 6-14  aromatic hydrocarbon ring group, the 5- to 14-membered aromatic heterocyclic group and isoxazolinyl may be independently substituted with at least one group selected from the group consisting of C 1-6  alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, nitro, amino, C 1-6  aminoalkyl, C 1-6  alkylamino, C 1-6  dialkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, alkylsulfonylamino, alkylsulfonyl, sulfamoyl, halogeno and C 3-8  cycloalkyl. 
     
   
   
       13 . The compound according to  claim 11  or a salt thereof, wherein Ar is a group represented by the formula: 
     
       
         
         
             
             
         
       
       wherein R 11  represents hydrogen, cyano, halogen, nitro or a group selected from Substituent Group B; 
       R 15  represents hydrogen or a group selected from Substituent Group H; 
       R 17  and R 18  are the same or different and each represents hydrogen or a group selected from Substituent Group I, or 
       R 11  and R 15 , R 15  and R 17 , R 15  and R 18 , or R 17  and R 18  may bond together to form a 5- to 8-membered heterocycle optionally substituted with at least one group selected from Substituent Group F and optionally having 1 or 2 hetero atoms selected from N, S and O; 
       Substituent Group F represents moieties selected from the group consisting of hydrogen, cyano, halogen, oxo and C 1-6  alkyl, alkenyl, alkynyl, acyl, C 1-6  alkanoyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, imino, C 1-6  aminoalkyl, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, sulfonylamino, sulfonyl, sulfamoyl, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group F′; 
       Substituent Group F′ represents moieties selected form the group consisting of C 1-6  alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, benzyloxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, C 1-6  alkylsulfonylamino, C 1-6  alkylsulfonyl, sulfamoyl, halogeno, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group; 
       Substituent Group H represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, acyl, C 1-6  alkoxycarbonyl, aminocarbonyl, C 1-6  alkylaminocarbonyl, C 3-8  cycloalkyl, C 1-6  aminoalkyl, sulfonyl, C 3-8  cycloalkylamino, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group H′; 
       Substituent Group H′ represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, oxo, cyano, C 1-6  cyanoalkyl, C 2-7  acyl C 1-6  alkanoyl, benzoyl, aralkanoyl, C 1-6  alkoxyalkylcarbonyl, C 1-6  hydroxyalkylcarbonyl, carboxyl, C 1-6  carboxyalkyl, C 1-6  carboxyalkyloxy, carbamoyl, carbamoylalkyloxy, C 1-6  alkoxycarbonyl, C 1-10  alkoxycarbonyl-C 1-6  alkyl, C 1-10  alkoxycarbonyl-C 1-6  alkyloxy, C 1-6  monoalkylaminocarbonyl, C 2-6  dialkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 1-10  alkoxyalkyl, C 1-10  aralkyloxyalkyl, C 1-6  hydroxyalkyl, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, C 1-6  alkylsulfonylamino, phenylsulfonylamino, C 1-6  alkylsulfonyl, phenylsulfonyl, C 1-6  monoalkylaminosulfonyl, C 2-6  dialkylaminosulfonyl, sulfamoyl, halogeno, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group, a 5- to 14-membered aromatic heterocyclic group, a heterocyclic aminocarbonyl group, a heterocyclic aminosulfonyl group and isoxazolinyl, wherein the 5- to 14-membered non-aromatic heterocyclic group, the C 6-14  aromatic hydrocarbon ring group the 5- to 14-membered aromatic heterocyclic group and isoxazolinyl may be independently substituted with at least one group selected from the group consisting of C 1-6  alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy C 3-8  cycloalkyloxy, nitro, amino, C 1-6  aminoalkyl, C 1-6  alkylamino, C 1-6  dialkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, alkylsulfonylamino, alkylsulfonyl, sulfamoyl, halogeno and C 3-8  cycloalkyl; 
       Substituent Group I represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, acyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, C 1-6  aminoalkyl, sulfonyl, sulfamoyl, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group and a 5- to 14-membered aromatic heterocyclic group, each of the foregoing members being optionally substituted with at least one group selected from Substituent Group I′; and 
       Substituent Group I′ represents moieties selected from the group consisting of C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, oxo, cyano, C 1-6  cyanoalkyl, C 2-7  acyl, C 1-6  alkanoyl, benzoyl, aralkanoyl, C 1-6  alkoxyalkylcarbonyl, C 1-6  hydroxyalkylcarbonyl, carboxyl, C 1-6  carboxyalkyl, C 1-6  carboxyalkyloxy, carbamoyl, carbamoylalkyloxy, C 1-6  alkoxycarbonyl, C 1-10  alkoxycarbonyl-C 1-6  alkyl, C 1-10  alkoxycarbonyl-C 1-6  alkyloxy, C 1-6  monoalkylaminocarbonyl, C 2-6  dialkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 1-10  alkoxyalkyl, C 1-10  aralkyloxyalkyl, C 1-6  hydroxyalkyl, C 3-8  cycloalkyloxy, amino, C 1-6  alkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, C 1-6  alkylsulfonylamino, phenylsulfonylamino, C 1-6  alkylsulfonyl, phenylsulfonyl, C 1-6  monoalkylaminosulfonyl, C 2-6  dialkylaminosulfonyl, sulfamoyl, halogeno, C 3-8  cycloalkyl, a 5- to 14-membered non-aromatic heterocyclic group, a C 6-14  aromatic hydrocarbon ring group, a 5- to 14-membered aromatic heterocyclic group, a heterocyclic aminocarbonyl group, a heterocyclic aminosulfonyl group and isoxazolinyl, wherein the 5- to 14-membered non-aromatic heterocyclic group, the C 6-14  aromatic hydrocarbon ring group, the 5- to 14-membered aromatic heterocyclic group and isoxazolinyl may be independently substituted with at least one group selected from the group consisting of C 1-6  alkyl, oxo, cyano, acyl, carboxyl, carbamoyl, C 1-6  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, hydroxyl, C 1-6  alkoxy, C 3-8  cycloalkyloxy, nitro, amino, C 1-6  aminoalkyl, C 1-6  alkylamino, C 1-6  dialkylamino, C 3-8  cycloalkylamino, acylamino, ureido, ureylene, alkylsulfonylamino, alkylsulfonyl, sulfamoyl, halogeno and C 3-8  cycloalkyl. 
     
   
   
       14 . A pharmaceutical composition comprising a compound according to  claim 1  or a salt thereof. 
   
   
       15 . The composition according to  claim 14 , wherein the compound is a thrombin receptor antagonist. 
   
   
       16 . The composition according to  claim 14 , wherein the compound is a thrombin receptor PAR1 antagonist. 
   
   
       17 . The composition according to  claim 14 , wherein the compound is a platelet aggregation inhibitor. 
   
   
       18 . The composition according to  claim 14 , wherein the compound is a proliferation inhibitor for smooth muscle cells. 
   
   
       19 . The composition according to  claim 14 , wherein the compound is a proliferation inhibitor for endothelial cells, fibroblasts, nephrocytes, osteosarcoma cells, muscle cells, cancer cells and/or glia cells. 
   
   
       20 . The composition according to  claim 14 , wherein the compound is a therapeutic or prophylactic agent for thrombosis, vascular restenosis, deep venous thrombosis, pulmonary embolism, cerebral infarction, heart disease, disseminated intravascular coagulation, hypertension, inflammatory disease, rheumatism, asthma, glomerulonephritis, osteoporosis, neurological disease and/or malignant tumor. 
   
   
       21 . (canceled) 
   
   
       22 . (canceled) 
   
   
       23 . (canceled) 
   
   
       24 . A method for treating a disease associated with thrombin receptors, comprising administering to a patient suffering from the disease, a therapeutically effective dose of a compound according to  claim 1  or  claim 11  or a salt thereof. 
   
   
       25 . A method for treating a proliferative disease of endothelial cells, fibroblasts, nephrocytes, osteosarcoma cells, muscle cells, cancer cells and/or glia cells, comprising administering to a patient suffering from the disease, a therapeutically effective dose of a compound according to  claim 1  or  claim 11  or a salt thereof.