Cancer Diagnostic Panel

Abstract

A method of diagnosing cancer by identifying differential modulation of each gene (relative to the expression of the same genes in a normal population) in a combination of genes selected from two groups of genes. Gene expression portfolios and kits for employing the method are further aspects of the invention.

1 . An assay having a portfolio comprising isolated nucleic acid sequences, their complements, or portions thereof of a combination of genes selected from the group consisting of Seq. ID. No. 1-30, Seq. ID No. 32, Seq. ID No. 34 and Seq. ID No. 98. 
     
     
         2 . The assay portfolio of  claim 1  in a matrix suitable for identifying the differential expression of the genes contained therein. 
     
     
         3 . The assay of  claim 2  wherein said matrix is employed in a microarray. 
     
     
         4 . The assay of  claim 3  wherein said microarray is a cDNA microarray. 
     
     
         5 . The assay of  claim 3  wherein said microarray is an oligonucleotide microarray. 
     
     
         6 . An assay having a portfolio comprising isolated nucleic acid sequences, their complements, or portions thereof of a combination of genes selected from the group consisting of Seq. ID. No. 32-67, Seq. ID No. 69, and Seq. ID No. 98-100. 
     
     
         7 . The assay of  claim 6  in a matrix suitable for identifying the differential expression of the genes contained therein. 
     
     
         8 . The assay of  claim 7  wherein said matrix is employed in a microarray. 
     
     
         9 . The assay of  claim 8  wherein said microarray is a cDNA microarray. 
     
     
         10 . The assay of  claim 8  wherein said microarray is an oligonucleotide microarray. 
     
     
         11 . A kit for diagnosing cancer comprising reagents for the detection of the expression of a combination of genes selected from the group consisting of Seq. ID. No. 1-30, Seq. ID No. 32, Seq. ID No. 34 and Seq. ID No. 98. 
     
     
         12 . The kit of  claim 11  further comprising reagents for conducting a microarray analysis. 
     
     
         13 . The kit of  claim 11  further comprising a medium through which nucleic acid sequences within said genes, their compliments, or portions thereof are assayed. 
     
     
         14 . The kit of  claim 13  wherein said medium is a microarray. 
     
     
         15 . The kit of  claim 11  further comprising instructions. 
     
     
         16 . A kit for diagnosing cancer comprising reagents for the detection of the expression of genes selected from the group consisting of Seq. ID. No.32-67, Seq. ID No. 69, and Seq. ID No. 98-100. 
     
     
         17 . The kit of  claim 16  further comprising reagents for conducting a microarray analysis. 
     
     
         18 . The kit of  claim 16  further comprising a medium through which nucleic acid sequences within said genes, their compliments, or portions thereof are assayed. 
     
     
         19 . The kit of  claim 18  wherein said medium is a microarray. 
     
     
         20 . The kit of  claim 19  further comprising instructions.