Method for antagonizing MIF activity

Abstract

Methods of antagonizing MIF activity using ibudilast are described. Also described are methods of screening for MIF antagonists. These agents can be used for treating addictions, including drug and behavioral addictions, as well as for treating neuropathic pain.

What is claimed is: 
     
         1 . A method for inhibiting macrophage migration inhibitory factor (MIF) activity in a vertebrate subject in need thereof, comprising providing a therapeutically effective amount of ibudilast to said vertebrate subject. 
     
     
         2 . The method of  claim 1 , wherein the subject is human. 
     
     
         3 . The method of  claim 1 , wherein the ibudilast is administered systemically. 
     
     
         4 . The method of  claim 3 , wherein the ibudilast is administered intravenously, subcutaneously, orally, intranasally, or sublingually. 
     
     
         5 . The method of  claim 1 , wherein the ibudilast is administered centrally. 
     
     
         6 . The method of  claim 5 , wherein the ibudilast is administered intrathecally. 
     
     
         7 . The method of  claim 1 , wherein multiple therapeutically effective doses of ibudilast are administered to the subject. 
     
     
         8 . The method of  claim 7 , wherein ibudilast is administered according to a daily dosing regimen. 
     
     
         9 . The method of  claim 8 , wherein ibudilast is administered twice a day. 
     
     
         10 . The method of  claim 1 I wherein ibudilast is administered intermittently.