Compounds, Compositions Containing Them, Preparation Thereof and Uses Thereof I

Abstract

Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R 1 , R 2 , R 3 , R 4 , R 5 , and G are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

1 - 10 . (canceled) 
   
   
       11 . A method for the treatment of anxiety disorders comprising the step of administering to said animal in need of such therapy a therapeutically effective amount of a compound of formula I, a pharmaceutically acceptable salt thereof, diastereomers, enantiomers, or mixtures thereof: 
     
       
         
         
             
             
         
       
     
     wherein
 G is selected from —O— and —CF 2 —; 
 R 1  is selected from C 1-6 alkyl and C 3-6 cycloalkyl; 
 R 2  is selected from —H and methyl; and 
 R 3 , R 4  and R 5  are independently selected from fluoro and methyl. 
 
   
   
       12 . A method for the treatment of cancer, multiple sclerosis, Parkinson's disease, Huntington's chorea, Alzheimer's disease, gastrointestinal disorders and cardiovascular disorders comprising the step of administering to said animal in need of such therapy a therapeutically effective amount of a compound of formula I, a pharmaceutically acceptable salt thereof, diastereomers, enantiomers, or mixtures thereof: 
     
       
         
         
             
             
         
       
     
     wherein
 G is selected from —O— and —CF 2    
 R 1  is selected from C 1-6 alkyl and C 3-6 cycloalkyl; 
 R 2  is selected from —H and methyl; and 
 R 3 , R 4  and R 5  are independently selected from fluoro and methyl. 
 
   
   
       13 . (canceled) 
   
   
       14 . A method for the therapy of pain in a warm-blooded animal, comprising the step of administering to said animal in need of such therapy a therapeutically effective amount of a compound of formula I, a pharmaceutically acceptable salt thereof, diastereomers, enantiomers, or mixtures thereof: 
     
       
         
         
             
             
         
       
     
     wherein
 G is selected from —O— and —CF 2 —; 
 R 1  is selected from C 1-6 alkyl and C 3 cycloalkyl; 
 R 2  is selected from —H and methyl; and 
 R 3 , R 4  and R 5  are independently selected from fluoro and methyl. 
 
   
   
       15 . (canceled) 
   
   
       16 . The method as claimed in  claim 14 , wherein
 R 1  is selected from C 1-4 alkyl and C 3-4 cycloalkyl.   
   
   
       17 . The method as claimed in  claim 14 , wherein
 G is —O—;   R 1  is selected from ethyl, propyl and cyclopropyl; and   R 3 , R 4  and R 5  are independently selected from fluoro and methyl with R 3 , R 4  and R 5  being the same.   
   
   
       18 . The method as claimed in  claim 14 , wherein
 G is —CF 2 —;   R 1  is selected from ethyl, propyl and cyclopropyl; and   R 3 , R 4  and R 5  are independently selected from fluoro and methyl with R 3 , R 4  and R 5  being the same.   
   
   
       19 . The method as  claim 14 , wherein the compound is selected from 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
   
   
       20 . The method as claimed in  claim 14 , 
     wherein
 G is selected from —O—, —CHF— and —CF 2 —; 
 R 1  is selected from C 1-6 alkyl and C 3-6 cycloalkyl; 
 R 2  is selected from —H and methyl; and 
 R 3 , R 4  and R 5  are independently selected from fluoro and methyl. 
 
   
   
       21 . The method as claimed in  claim 20 , wherein G is selected from —CHF— and —CF 2 —. 
   
   
       22 . The method as claimed in  claim 20 , wherein R 1  is selected from ethyl, propyl, t-butyl and cyclopropyl.