US2009221786A1PendingUtilityA1
Taxol immunoassay
Est. expiryJul 29, 2024(expired)· nominal 20-yr term from priority
G01N 33/94G01N 33/5308G01N 2407/02Y10S436/815
61
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Claims
Abstract
Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for the quantification and monitoring of taxol in biological fluids.
Claims
exact text as granted — not AI-modified1 . A compound of the formula:
wherein A is
Y is an organic spacing group;
X is a functional terminal group capable of binding to a polyamine polypeptide; and
p is an integer from 0 to 1.
2 . The compound of claim 1 , wherein p is 0.
3 . The compound of claim 2 , wherein X is
wherein R 3 is hydrogen or taken together with its attached oxygen atom forms a reactive ester and R is oxygen or sulfur.
4 . The compound of claim 3 , wherein X is
and R 3 is hydrogen.
5 . The compound of claim 3 , wherein X is
and R 3 forms a reactive ester.
6 . The compound of claim 5 , wherein the ester formed is a lower alkyl ester, imidoester or amidoester.
7 . The compound of claim 1 , wherein p is 1.
8 . The compound of claim 7 , wherein Y is alkylene containing from 1 to 10 carbon atoms,
wherein n and o are integers from 0 to 6, and m is an integer from 1 to 6.
9 . A compound of the formula:
wherein Y is an organic spacing group; p is an integer from 0 to 1;
X is a functional terminal group capable of binding to a polyamine polypeptide; and B is —CH 2 —
or mixtures thereof.
10 . The compound of claim 9 , wherein p is 0.
11 . The compound of claim 10 , wherein X is
wherein R 3 is hydrogen or taken together with its attached oxygen atom forms a reactive ester and R 4 is oxygen or sulfur.
12 . The compound of claim 11 , wherein X is
and R 3 is hydrogen.
13 . The compound of claim 12 , wherein X is
and R 3 forms a reactive ester.
14 . The compound of claim 13 , wherein the ester formed is a lower alkyl ester, imidoester or amidoester.
15 . The compound of claim 14 , wherein p is 1.
16 . The compound of claim 15 , wherein X is
wherein R 3 is hydrogen or taken together with its attached oxygen atom forms a reactive ester and R 4 is oxygen or sulfur.
17 . The compound of claim 16 , wherein Y is alkylene containing from 1 to 10 carbon atoms,
wherein n and o are integers from 0 to 6, and m is an integer from 1 to 6.
18 . A conjugate of a carrier with a compound of the formula:
wherein A is
Y is an organic spacing group;
X is a functional terminal group capable of binding to a polyamine polypeptide; and
p is an integer from 0 to 1.
19 . The conjugate of claim 18 , wherein p is 0.
20 . The conjugate of claim 19 , wherein X is
wherein R 3 is hydrogen or taken together with its attached oxygen atom forms a reactive ester and R 4 is oxygen or sulfur.
21 . The conjugate of claim 19 , wherein p is 1 and Y is alkylene containing from 1 to 10 carbon atoms.
wherein n and o are integers from 0 to 6, and m is an integer from 1 to 6.
22 . The conjugate of claim 21 , wherein the carrier contains one or more amino
groups linked by
wherein R 4 is oxygen or sulfur.
23 . A compound of the formula:
wherein
Y is an organic spacing group;
X is a functional terminal group capable of binding to a polyamine polypeptide; p is an integer from 0 to 1; and
B is —CH 2 —
or mixtures thereof.
24 . The compound of claim 23 , wherein p is 0.
25 . The compound of claim 24 , wherein X is
wherein R 3 is hydrogen or taken together with its attached oxygen atom forms a reactive ester and R 4 is oxygen or sulfur.
26 . The compound of claim 23 , wherein p is 1.
27 . The compound of claim 26 , wherein Y is alkylene containing from 1 to 10 carbon atoms,
wherein n and o are integers from 0 to 6, and m is an integer from 1 to 6.
28 . The compound of claim 27 , wherein X is
wherein R 3 is hydrogen or taken together with its attached oxygen atom forms a reactive ester and R 4 is oxygen or sulfur.
29 . An immunogen containing an immunogenic polyamine polymer linked to a compound of the formula:
wherein A is
Y is an organic spacing group;
X is a functional terminal group capable of binding to a polyamine polypeptide; and
p is an integer from 0 to 1.
30 . The compound of claim 29 , wherein p is 0.
31 . The compound of claim 29 , wherein p is 1.
32 . The compound of claim 31 , wherein Y is alkylene containing from 1 to 10 carbon atoms,
wherein n and o are integers from 0 to 6, and m is an integer from 1 to 6.
33 . The compound of claim 32 , wherein the immunogenic polymer contains one or more amino groups linked by
wherein R 4 is oxygen or sulfur.
34 . An immunogen comprising an immunogenic polyamine polymer linked to a compound of the formula:
wherein B is —CH 2 —;
Y is an organic spacing group;
X is a functional terminal group capable of binding to a polyamine polypeptide; and
p is an integer from 0 to 1.
35 . The compound of claim 34 , wherein p is 0.
36 . The compound of claim 35 , wherein the immunogenic polymer contains one or more amino groups linked by
wherein R 4 is oxygen or sulfur.
37 . The compound of claim 34 , wherein p is 1.
38 . The compound of claim 37 , wherein Y is alkylene containing from 1 to 10 carbon atoms,
wherein n and o are integers from 0 to 6, and m is an integer from 1 to 6.
39 . The compound of claim 38 , wherein the immunogenic polymer contains one or more amino groups linked by
wherein R 4 is oxygen or sulfur.Cited by (0)
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