Antitumoral Treatments

Abstract

Aplidine and aplidine analogues are of use for the treatment of cancer, in particular in the treatment of leukemias and lymphomas, especially in combination therapies.

1 . A method of treating leukemia or lymphoma comprising administering to a patient in need of such treatment a synergistic amount of aplidine and a drug, wherein said drug is selected from the group consisting of vinblastine and doxorubicin. 
   
   
       2 . The method according to  claim 1 , wherein said method is a method of treating leukemia. 
   
   
       3 . The method according to  claim 2 , wherein said drug is vinblastine. 
   
   
       4 . The method according to  claim 2 , wherein said drug is doxorubicin. 
   
   
       5 . The method according to  claim 1 , wherein said method is a method of treating lymphoma. 
   
   
       6 . The method according to  claim 5 , wherein said drug is vinblastine. 
   
   
       7 . The method according to  claim 5 , wherein said drug is doxorubicin. 
   
   
       8 . The method according to  claim 1 , wherein said aplidine is administered prior, with, or after administering said drug selected from the group consisting of vinblastine and doxorubicin. 
   
   
       9 . The method according to  claim 8 , wherein said aplidine is administered prior to said drug selected from the group consisting of vinblastine and doxorubicin. 
   
   
       10 . The method according to  claim 8 , wherein said aplidine is administered with said drug selected from the group consisting of vinblastine and doxorubicin. 
   
   
       11 . The method according to  claim 8 , wherein said aplidine is administered after said drug selected from the group consisting of vinblastine and doxorubicin. 
   
   
       12 . A method of increasing the therapeutic efficacy of a drug effective in the treatment of leukemia or lymphoma wherein said drug is selected from the group consisting of vinblastine and doxorubicin, and wherein said method comprises administering a synergistic amount of said drug and aplidine to a patient in thereof. 
   
   
       13 . The method according to  claim 12 , wherein said treatment is treatment of leukemia. 
   
   
       14 . The method according to  claim 13 , wherein said drug is vinblastine. 
   
   
       15 . The method according to  claim 13 , wherein said drug is doxorubicin. 
   
   
       16 . The method according to  claim 12 , wherein said treatment is treatment of lymphoma. 
   
   
       17 . The method according to  claim 16 , wherein said drug is vinblastine. 
   
   
       18 . The method according to  claim 16 , wherein said drug is doxorubicin. 
   
   
       19 . A kit for use in the treatment of leukemia or lymphoma which comprises a dosage form of aplidine, a dosage form of a drug selected from the group consisting of vinblastine and doxorubicin, and instructions for the use of aplidine and said drug in combination for the treatment of cancer.