Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl

Abstract

Silicone adhesive formulations are provided, in which fentanyl particles are suspended one or more a solvated silicone adhesives. The formulations can be used for manufacturing improved, matrix-type transdermal devices for administering fentanyl.

1 . A monolithic transdermal patch comprising:
 (a) a backing layer having inner and outer surfaces; and   (b) a first adhesive layer having a first surface covering at least a portion of said inner surface of said backing layer,   said adhesive layer comprising a therapeutically-effective amount of fentanyl in an adhesive, wherein less than 1% of said fentanyl can be dissolved in said adhesive when said adhesive is fully solvated with a solvent capable of fully solvating or dissolving said adhesive.   
     
     
         2 - 20 . (canceled)