Solution for preserving liver

Abstract

The present invention provides a liver preservation solution containing trehalose and dibutyryl-cAMP. The content of nitroglycerin in the preservation solution is preferably lower than 0.44 mM. In the liver preservation solution of the present invention, since the toxicity due to nitroglycerin, which is observed during liver preservation, has been improved, liver transplantation can be performed with a high engrafted rate.

1 . A liver preservation solution comprising trehalose and dibutyryl cAMP. 
   
   
       2 . The preservation solution of  claim 1 , having a nitroglycerin content of lower than 0.44 mM. 
   
   
       3 . The preservation solution of  claim 1 , having a nitroglycerin content of not more than 0.0044 mM. 
   
   
       4 . The preservation solution of  claim 1 , which is substantially free of nitroglycerin. 
   
   
       5 . The preservation solution of  claim 1 , wherein the concentration of dibutyryl cAMP is within the range of 0.005-10 mM. 
   
   
       6 . The preservation solution of  claim 1 , wherein the concentration of trehalose is within the range of 50-240 mM. 
   
   
       7 . The preservation solution of  claim 1 , further comprising hydroxyethylstarch. 
   
   
       8 . The preservation solution of  claim 1 , further comprising at least the following components within the following range: 
     
       
         
               
               
               
               
             
                   
                   
               
                   
                 Na +   
                 10-140 
                 mM 
               
                   
                 K +   
                 4-140 
                 mM 
               
                   
                 H 2 PO 4   −  or HPO 4   −−   
                 12-65 
                 mM 
               
                   
                 at least one kind selected from 
                 15-150 
                 mM. 
               
                   
                 Cl − , HCO 3   − , CO 3   −− , organic acid 
               
                   
                 and organic acid anion 
               
                   
                   
               
           
              
             
             
              
              
              
              
              
              
              
             
          
         
       
     
   
   
       9 . A liver preservation solution comprising at least the following components within the following range: 
     
       
         
               
               
               
               
             
                   
                   
               
                   
                 dibutyryl cAMP 
                 0.005-10 
                 mM 
               
                   
                 trehalose 
                 50-240 
                 mM 
               
                   
                 hydroxyethylstarch 
                 1-80 
                 g/l 
               
                   
                 Na +   
                 10-140 
                 mM 
               
                   
                 K +   
                 4-140 
                 mM 
               
                   
                 H 2 PO 4   −  or HPO 4   −−   
                 12-65 
                 mM 
               
                   
                 at least one kind selected from 
                 15-150 
                 mM. 
               
                   
                 Cl − , HCO 3   − , CO 3   −− , organic acid 
               
                   
                 and organic acid anion 
               
                   
                   
               
           
              
             
             
              
              
              
              
              
              
              
              
              
              
             
          
         
       
     
   
   
       10 . The preservation solution of  claim 9 , having a nitroglycerin content of lower than 0.44 mM. 
   
   
       11 . A kidney preservation solution comprising trehalose and dibutyryl cAMP.