Human GM-CSF antibodies

Abstract

Chimeric antibodies, as well as fusion proteins which comprise chimeric antibodies, are disclosed. The antibodies bind to GM-CSF, CD-30, and G250 antigen. The fusion proteins include biologically active portions of tumor necrosis factor, or full length tumor necrosis factor. Expression vectors adapted for production of the antibodies, as well as methods for manufacturing these, are also disclosed.

1 - 16 . (canceled) 
     
     
         17 . An isolated, humanized antibody which specifically binds to granulocyte, macrophage, colony stimulating factor (GM-CSF). 
     
     
         18 . The isolated, humanized antibody of  claim 17 , wherein a complementary determining region (CDR) thereof is of non-human origin. 
     
     
         19 . The isolated humanized antibody of  claim 18 , wherein said isolated humanized antibody comprises a light chain, complementary determining region (CDR) of murine origin. 
     
     
         20 . The isolated humanized antibody of  claim 18 , wherein said isolated humanized antibody comprises a heavy chain, complementary determining region (CDR) of murine origin. 
     
     
         21 . The isolated humanized antibody of  claim 18 , wherein said isolated humanized antibody comprises both a light chain, complementary determining region (CDR) of murine origin, and a heavy chain, complementary determining region (CDR) of murine origin. 
     
     
         22 . The isolated humanized antibody of claim  5 , wherein both of said CDRs have an amino acid sequence identical to the CDR sequences of murine 19/2 antibody.