Formulation and method for relieving or preventing symptoms associated with uric acid crystals

Abstract

A method for relieving or preventing symptoms associated with uric acid crystals, comprising consuming a formulation that supports three or more processes, the processes comprising: 1) one that inhibits formation of uric acid in the body; 2) one that increases elimination of uric acid from the body; and 3) one that interferes with formation of uric acid crystals in the body. A formulation, comprising: an extract of celery; an extract of cherry; and a lithium salt. Also, a process to make a formulation, comprising mixing together: i. a material that inhibits formation of uric acid in a body; ii. a material that increases elimination of uric acid from the body; iii. a material that interferes with formation of uric acid crystals in the body; and forming the mixture into a medicament.

1 . A method for relieving or preventing symptoms associated with uric acid crystals, comprising consuming a formulation that supports three or more processes that reduce a symptom due to uric acid crystals in a body, the processes comprising:
 1) a process that inhibits formation of uric acid in the body;   2) a process that increases elimination of uric acid from the body; and   3) a process that interferes with formation of uric acid crystals in the body.   
   
   
       2 . The method of  claim 1 , wherein the formulation comprises an extract of celery, an extract of cherry, and a lithium salt. 
   
   
       3 . The method of  claim 2 , wherein the extract of celery is from a seed. 
   
   
       4 . The method of  claim 2 , wherein the extract of cherry is from a fruit. 
   
   
       5 . The method of  claim 2 , wherein the lithium salt is selected from lithium orotate, lithium aspartate, lithium proteinate, lithium citrate, lithium carbonate, and mixtures thereof. 
   
   
       6 . The method of  claim 2 , wherein the formulation comprises from 25 to 200 mg of extract of celery, from 100 to 1500 mg extract of cherry, and from 1.5 to 10 mg of lithium in the lithium salt; and wherein the formulation is consumed from one to four times per day. 
   
   
       7 . The method of  claim 1 , wherein the extract of celery is standardized to contain at least 50% 3-n-butylphthalide calculated as total phthalides. 
   
   
       8 . The method of  claim 4 , wherein the cherry fruit extract is sweet cherry ( Prunus avium ) fruit extract of at least 5:1. 
   
   
       9 . A formulation for relieving or preventing symptoms associated with uric acid crystals, comprising:
 a. an extract of celery;   b. an extract of cherry; and   c. a lithium salt.   
   
   
       10 . The formulation of  claim 9 , wherein the extract of celery is from a seed. 
   
   
       11 . The formulation of  claim 9 , wherein the extract of celery is standardized to contain at least 50% 3-n-butylphthalide calculated as total phthalides. 
   
   
       12 . The formulation of  claim 9 , wherein the extract of cherry is from a fruit. 
   
   
       13 . The formulation of  claim 9 , wherein the extract of cherry is sweet cherry ( Prunus avium ) fruit extract of at least a 5:1 concentrate. 
   
   
       14 . The formulation of  claim 9 , comprising from 25 to 200 mg of extract of celery, from 100 to 1500 mg extract of cherry, and from 1.5 to 10 mg of lithium in the lithium salt in a medicament selected from the group consisting of a tablet, a capsule, a pill, a softgel, a suspension, and a powder. 
   
   
       15 . The formulation of  claim 9 , comprising less than 5 wt % inert filler. 
   
   
       16 . The formulation of  claim 9 , that is a high dose formulation for acute gout phase treatment. 
   
   
       17 . The formulation of  claim 9 , that is a low dose formulation for preventative treatment of gout, kidney stones, or a combination thereof. 
   
   
       18 . The formulation of  claim 9 , wherein the formulation is a mixture made of dry particles. 
   
   
       19 . A process to make a formulation for relieving or preventing symptoms associated with uric acid crystals, comprising:
 a. mixing together:
 i. a material that when consumed inhibits formation of uric acid in a body; 
 ii. a material that when consumed increases elimination of uric acid from the body; 
 iii. a material that when consumed interferes with formation of uric acid crystals in the body; and 
   b. forming the mixture of step (a) into a medicament.   
   
   
       20 . The process of  claim 19 , wherein the material that when consumed inhibits formation of uric acid in the body is celery seed extract; the material that when consumed increases elimination of uric acid from the body is cherry fruit extract; and wherein the material that when consumed interferes with formation of uric acid crystals in the body is lithium salt.