Combined effects of nutrients on proliferation of stem cells

Abstract

A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.

1 . A method of increasing stem cell proliferation comprising:
 selecting at least three substances from the group of substances consisting of blueberry, carnosine, catechin, green tea extract, and vitamin D 3 ;   compounding the substances;   and administering the substances to a mammal.   
   
   
       2 . The method of  claim 1 , wherein the step of selecting is further limited to selecting blueberry and vitamin D 3  as two of the at least three substances. 
   
   
       3 . The method of  claim 2 , wherein the step of selecting is further limited to selecting green tea extract as one of the at least three substances. 
   
   
       4 . The method of  claim 1 , wherein the step of selecting includes selecting at least one of the group consisting of carnosine and catechin. 
   
   
       5 . The method of  claim 1 , wherein the step of selecting is further limited to selecting blueberry extract, carnosine, green tea extract, and vitamin D 3 . 
   
   
       6 . The method of  claim 1 , further comprising, stimulating expression of phenotypes useful for repairing cells damaged by injury and disease. 
   
   
       7 . The method of  claim 6 , wherein the step of selecting is further limited to selecting blueberry extract, carnosine, green tea extract, and vitamin D 3 . 
   
   
       8 . The method of  claim 7 , further comprising stimulating expression of neuronal cells following brain injury. 
   
   
       9 . The method of  claim 7 , wherein the step of selecting includes selecting the composition of Composition 1. 
   
   
       10 . A composition comprising at least three substances selected from the group of substances consisting of blueberry, carnosine, green tea extract and vitamin D 3 . 
   
   
       11 . The composition of  claim 10 , wherein blueberry and vitamin D 3  are selected as two of the at least three substances and the ratio of blueberry to vitamin D 3  is selected in a range from 12.5:1 to 1:12.5. 
   
   
       12 . The composition of  claim 10 , wherein the composition comprises blueberry, carnosine, green tea extract and vitamin D 3 . 
   
   
       13 . The composition of  claim 11 , wherein the composition comprises at least 400 milligrams of blueberry. 
   
   
       14 . The composition of  claim 10 , wherein the composition includes green tea extract in a range from 400 mg to 5 grams. 
   
   
       15 . The composition of  claim 10 , wherein active ingredients of the composition consists of blueberry, vitamin D 3 , green tea extract, and carnosine. 
   
   
       16 . The composition of  claim 16  for use in adult humans, wherein an amount of blueberry is at least 400 mg, an amount of green tea is at least 400 mg, an amount of carnosine is at least 10 mg and an amount of Vitamin D 3  of at least 50 mg. 
   
   
       17 . A system for preventing and repairing cell damage in a animal caused by aging, injury, or disease, comprising:
 selecting a supplement, the supplement comprising a combination of at least three substances selected from the group of substances consisting of blueberry, carnosine, catechin, green tea extract and vitamin D 3 ;   administering a therapeutically effective amount of the supplement for stimulating proliferation of stem cells;   and continuing the step of administering for at least an effective duration.   
   
   
       18 . The system of  claim 18 , wherein the step of selecting is further limited to selecting blueberry and vitamin D 3  as two of the at least three substances. 
   
   
       19 . The system of  claim 19 , wherein the step of selecting is further limited to selecting green tea extract and either carnosine or catechin. 
   
   
       20 . The system of  claim 19 , wherein the step of selecting is further limited to selecting green tea extract and carnosine. 
   
   
       21 . The system of  claim 18 , wherein the step of selecting is further limited to selecting blueberry and green tea extract as two of the at least three substances. 
   
   
       22 . The system of  claim 18 , wherein the step of administering includes using at least 400 mg of the blueberry, at least 400 mg of the green tea extract, and at least 50 μg of the vitamin D 3  administered at least once daily. 
   
   
       23 . The system of  claim 18 , wherein the step of administering includes using at least 200 mg of blueberry, at least 400 mg of green tea extract, and at least 50 μg of vitamin D 3 , administered at least twice daily. 
   
   
       24 . The system of  claim 18 , wherein the step of administering includes using at least 400 mg of blueberry, at least 400 mg of green tea extract, a range of vitamin D 3  of 2000 IU to 4000 IU and at least 10 mg of carnosine, administered at least once daily. 
   
   
       25 . The system of  claim 18 , wherein the step of administering includes using a range of 400 mg to 5 grams the blueberry extract, 400 mg to 5 grams of green tea extract, 2000 IU to 4000 IU of the vitamin D 3  and 10 mg to 100 mg of carnosine in the form of a compounded supplement. 
   
   
       26 . The system of  claim 18 , wherein the therapeutically effective amount of the supplement includes a range of blueberry from 400 mg/day to 5 grams/per day. 
   
   
       27 . The system of  claim 18 , wherein the therapeutically effective amount of the supplement includes a range of green tea extract from 400 mg/day to 5 grams/per day. 
   
   
       28 . The system of  claim 18 , wherein the therapeutically effective amount of the supplement includes a range of carnosine from 10 mg/day to 100 mg/per day. 
   
   
       29 . The system of  claim 18 , wherein the therapeutically effective amount of the supplement includes a range of blueberry from 2000 IU per day to 4000 IU per day. 
   
   
       30 . A composition for increasing stem cell proliferation comprising an effective amount of at least two substances selected from the group of substances consisting of blueberry, carnosine, green tea extract and vitamin D 3 , such that the combination of at least two substances exerts a synergistic effect on the stem cell proliferation. 
   
   
       31 . The composition of  claim 32  for use in humans, such that the first of the two substances selected is blueberry in a range of 400 mg to 5 grams and the second of the two substances selected is vitamin D 3  in a range of 50-100 μg. 
   
   
       32 . The composition of  claim 31  for use in humans, such that the first of the two substances selected is blueberry in a range of 400 mg to 5 grams and the second of the two substances selected is carnosine in a range of 10-100 mg. 
   
   
       33 . The composition of  claim 31  for use in humans, such that the first of the two substances selected is blueberry in a range of 400 mg to 5 grams and the second of the two substances selected is green tea extract in a range of 400 mg to 5 grams. 
   
   
       34 . The composition of  claim 33  for use in humans, further comprising a range of 2000 IU to 4000 IU of Vitamin D 3 . 
   
   
       35 . The composition of  claim 33  for use in humans, further comprising a range of 2000 IU to 4000 IU of Vitamin D 3 . 
   
   
       36 . The composition of  claim 36  for use in humans, further comprising a range of 400 mg to 5 grams of green tea extract.