Chemokine receptor binding heterocyclic compounds with enhanced efficacy

Abstract

Compounds that interact with the CXCR4 receptor are described. These compounds are useful in treating, for Example, HIV infection and inflammatory conditions such as rheumatoid arthritis, as well as asthma or cancer, and are useful in methods to elevate progenitor and stem cell counts as well as methods to elevate white blood cell counts.

1 . A compound of the formula 
       
         
           
           
               
               
           
         
         wherein each of rings A and B is independently an optionally substituted 5-6 membered monocyclic heteroaryl; 
         ring C is a saturated or partially saturated ring of 5-8 members which is optionally substituted; 
         Y is H, a C 1-6  alkyl containing one or more heteroatoms, or a cyclic moiety, each of which is optionally substituted; 
         L is (CR 3   2 ) 1  or NR(CR 3   2 ) 1  wherein an alkyl bond may be replaced with an alkenyl or alkynyl bond; 
         where each R 3  is H or alkyl; 
         l is 1-6; 
         R 1  and R 2  are independently H or a non-interfering substituent; wherein at least one of R 1  and R 2  is not H when C is piperidinyl or 1,2,3,6-tetrahydropyridinyl and rings A and B are pyridinyl; and R 1  and R 2  are not both naphthalenyl when C is piperidinyl and rings A and B are pyridinyl; 
         provided that if L-Y is CH 3 , C is not 4-oxo-piperidine-3,5-dicarboxylic acid; and 
         if L-Y is benzyl, C is not 4-hydroxy-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid ester.