Anti-PECAM Therapy for Metastasis Suppression

Abstract

The invention provides novel compositions, methods, kits, and uses thereof relating to antimetastatic agents useful for treating neoplastic diseases.

1 - 13 . (canceled) 
     
     
         14 . A kit for repressing or preventing metastasis or invasiveness of a neoplastic cell in a mammal, the kit comprising a therapeutically effective amount of an anti-PECAM binding species and instructions for systemic administration of said anti-PECAM binding species to said mammal. 
     
     
         15 . The kit of  claim 14 , wherein the anti-PECAM binding species is a monoclonal antibody. 
     
     
         16 . The kit of  claim 15 , wherein the instructions specify administration of a plurality of doses wherein each dose comprises at least 200 micrograms of said monoclonal antibody. 
     
     
         17 . The kit of  claim 16 , wherein the instructions specify that said monoclonal antibody is administered in at least five doses with each dose separated by at least two days from other doses in the plurality. 
     
     
         18 . The kit of  claim 15 , wherein the instructions specify that the monoclonal antibody may be combined with other anti-neoplastic therapies. 
     
     
         19 . The kit of  claim 18 , wherein the other anti-neoplastic therapies comprise: ionizing radiation, chemotherapeutic agents, thermal abalation, anti-tumor monoclonal antibodies that do not bind to PECAM, implantation of radioisotopes seeds, and surgery. 
     
     
         20 . The use of an anti-PECAM monoclonal antibody to repress or prevent metastasis of a neoplastic cell in a mammal wherein said mammal has had neoplastic cells in its body for at least seven days prior to administration of said anti-PECAM monoclonal antibody.