Aminosugar, glycosaminoglycan, and s-adenosylmethionine composition for the treatment and repair of connective tissue

Abstract

A composition for the protection, treatment and repair and for reducing the inflammation of connective tissue in mammals and a method for the treatment of connective tissue in mammals by the administration of the composition. The composition includes S-Adenosylmethionine (SAM), and a component selected from an aminosugar or salts thereof (e.g., glucosamine) or glycosaminoglycans (e.g., chondroitin salts) or mixtures or fragments thereof. The composition optionally includes manganese which promotes the production of connective tissue matrix. The composition also optionally includes methyl donors or methyl donor cofactors, such as vitamin B12, vitamin B6, folic acid, dimethylglycine or trimethylglycine.

1 . A composition for treatment and repair and for reducing the inflammation of connective tissue in humans and animals comprising:
 S-Adenosylmethionine;   a glycosaminoglycan selected from the group consisting of chondroitin, chondroitin salts, fragments, and mixtures thereof; and   an aminosugar selected from the group consisting of glucosamine, glucosamine salts and mixtures thereof.   
   
   
       2 . The composition of  claim 1 , wherein the salt of glucosamine is selected from the group consisting of glucosamine hydrochloride, glucosamine sulfate, and N-acetylglucosamine. 
   
   
       3 . A method for the treatment and repair and for reducing the inflammation of connective tissue in humans and animals comprising the step of administering the S-Adenosylmethionine, the glycosaminoglycan, and the aminosugar of the composition of  claim 1 , to a human or an animal. 
   
   
       4 . The composition of  claim 1 , wherein a dose of the S-Adenosylmethionine ranges from about 2 mg to about 20,000 mg, a dose of the aminosugar ranges from about 50 mg to about 40,000 mg, and a dose of the glycosaminoglycan ranges from about 15 mg to about 30,000 mg. 
   
   
       5 . A method for the treatment and repair and for reducing the inflammation of connective tissue in humans and animals comprising the step of administering the composition of  claim 1  to a human or an animal. 
   
   
       6 . A method for the treatment and repair and for reducing the inflammation of connective tissue in humans and animals comprising the step of administering the S-Adenosylmethionine, the glycosaminoglycan, and the aminosugar of the composition of  claim 1  to a human or an animal. 
   
   
       7 . The method of  claim 6 , wherein each of the S-Adenosylmethionine, the aminosugar, or the glycosaminoglycan are administered orally, sublingually, nasally, gutturally, rectally, transdermally, or parenterally. 
   
   
       8 . A composition for treatment and repair and for reducing the inflammation of connective tissue in humans and animals comprising:
 S-Adenosylmethionine and an aminosugar selected from the group consisting of glucosamine, glucosamine salts and mixtures thereof.   
   
   
       9 . The composition of  claim 8 , wherein the salt of glucosamine is selected from the group consisting of glucosamine hydrochloride, glucosamine sulfate, and N-acetylglucosamine. 
   
   
       10 . A method for the treatment and repair and for reducing the inflammation of connective tissue in humans and animals comprising the step of administering the S-Adenosylmethionine and the aminosugar of the composition of  claim 8 , to a human or an animal. 
   
   
       11 . The composition of  claim 6 , wherein a dose of the S-Adenosylmethionine ranges from about 2 mg to about 20,000 mg, and a dose of the aminosugar ranges from about 50 mg to about 40,000 mg. 
   
   
       12 . A method for the treatment and repair and for reducing the inflammation of connective tissue in humans and animals comprising the step of administering the composition of  claim 8 , to a human or an animal. 
   
   
       13 . A composition for treatment and repair and for reducing the inflammation of connective tissue in humans and animals comprising:
 S-Adenosylmethionine and a glycosaminoglycan selected from the group consisting of chondroitin, chondroitin salts, fragments, and mixtures thereof.   
   
   
       14 . A method for the treatment and repair and for reducing the inflammation of connective tissue in humans and animals comprising the step of administering the S-Adenosylmethionine and the glycosaminoglycan of the composition of  claim 13 , to a human or an animal. 
   
   
       15 . The composition of  claim 13 , wherein a dose of the S-Adenosylmethionine ranges from about 2 mg to about 20,000 mg, and a dose of the glycosaminoglycan ranges from about 15 mg to about 30,000 mg. 
   
   
       16 . A composition for treatment and repair and for reducing the inflammation of connective tissue in humans and animals comprising:
 S-Adenosylmethionine and an aminosugar selected from the group consisting of glucosamine, glucosamine salts and mixtures thereof.   
   
   
       17 . The composition of  claim 16 , wherein the salt of glucosamine is selected from the group consisting of glucosamine hydrochloride, glucosamine sulfate, and N-acetylglucosamine. 
   
   
       18 . A method for the treatment and repair and for reducing the inflammation of connective tissue in humans and animals comprising the step of administering the S-Adenosylmethionine and the aminosugar of the composition of  claim 16 , to a human or an animal. 
   
   
       19 . The composition of  claim 16 , wherein a dose of the S-Adenosylmethionine ranges from about 2 mg to about 20,000 mg, and a dose of the aminosugar ranges from about 50 mg to about 40,000 mg. 
   
   
       20 . A method for the treatment and repair and for reducing the inflammation of connective tissue in humans and animals comprising the step of administering the composition of  claim 16  to a human or an animal.