Novel natural cyclodextrin complexes

Abstract

The present invention is directed to the novel use of complexes of cyclodextrin. In particular the invention is directed to a complex of a cyclodextrin selected from the group consisting of α-CD, β-CD and γ-CD and a cannabinoid selected from the classical cannabinoid-group consisting of canabinol, tetrahydrocanabinol and canabidiol.

1 . A complex comprising:
 (a) β-cyclodextrin   (b) a cannabinoid   
       wherein said complex is an insoluble powder form. 
     
     
         2 . A complex comprising:
 (a) γ-cyclodextrin   (b) a cannabinoid   
       wherein said complex is an insoluble powder form. 
     
     
         3 . The complex of  claim 1  wherein the cannabinoid is Δ 9 -tetrahydrocannabinol. 
     
     
         4 . The complex of  claim 1  or  claim 2  wherein the cannabinoid and cyclodextrin are present in the complex in a weight ratio, based on dry weight, of 1:3 to 1:1000. 
     
     
         5 . A pharmaceutical composition comprising the complex of  claim 1  or  claim 2  and at least one pharmaceutical acceptable carrier, adjuvant or additive. 
     
     
         6 . The pharmaceutical composition of  claim 5  wherein said composition is in a form suitable for sublingual or buccal administration. 
     
     
         7 . A pharmaceutical composition of  claim 5  which is a tablet, a capsule, a chewing gum, a lozenge, a pill or a pastille. 
     
     
         8 . A method of treatment of a subject comprising administering to the subject afflicted with or suffering from nausea, muscular spasms, multiple sclerosis, uterine cramps; bowel cramps, pain, migraine headache, glaucoma, asthma, inflammation, insomnia, high blood pressure, anxiety, convulsions, depression or psychosis, an effective amount of the complex of  claim 1  or  claim 2 . 
     
     
         9 . The method of  claim 8  wherein said composition is administered such that 0.1 to 50 mg of cannabinoid are administered per day. 
     
     
         10 . A method of  claim 8  wherein the composition is administered to the subject in need thereof by a buccal or a sublingual route.