Ang2 and Vegf Inhibitor Combinations

Abstract

The invention provides methods for using Ang2 inhibitors in combination with VEGF inhibitors to treat disease. The invention also provides compositions, kits, formulations, and specific disease treatments relating thereto.

1 . A composition comprising:
 (a) 2xCon4(C) and   (b) AMG 706 or 4TBPPAPC;   or a pharmaceutically acceptable salt of any or all thereof.   
   
   
       2 . A composition according to  claim 1 , comprising 2xCon4(C) and AMG 706; or a pharmaceutically acceptable salt of any or all thereof. 
   
   
       3 . A composition according to  claim 1 , comprising 2xCon4(C) and 4TBPPAPC; or a pharmaceutically acceptable salt of any or all thereof. 
   
   
       4 . A composition according to  claim 1 , comprising a pharmaceutically acceptable salt of 2xCon4(C), 4TBPPAPC, or AMG 706. 
   
   
       5 . A composition according to  claim 1 , wherein the composition is suitable for administration to a human patient to treat a disease. 
   
   
       6 . A method for treating a disease in a subject comprising administering to a subject by a route and in an amount effective to treat a disease therein:
 (a) 2xCon4(C), and   (b) AMG 706 or 4TBPPAPC   
     or a pharmaceutically acceptable salt of any or all thereof. 
   
   
       7 . A method according to  claim 6 , wherein 2xCon4(C) and AMG 706 are administered to the subject. 
   
   
       8 . A method according to  claim 6 , wherein 2xCon4(C) and 4TBPPAPC are administered to the subject. 
   
   
       9 . A method according to  claim 6 , wherein a salt of one or more of 2xCon4(C), 4TBPPAPC, or AMG 706 is administered to the subject. 
   
   
       10 . A method according to  claim 6 , wherein a pharmaceutically acceptable formulation of 2xCon4(C), 4TBPPAPC or AMG 706 is administered to the subject. 
   
   
       11 . A method according to  claim 6 , wherein the subject is a human patient. 
   
   
       12 . A method according to  claim 6 , wherein (a) and (b) are administered sequentially in any order. 
   
   
       13 . A method according to  claim 6 , wherein (a) and (b) are administered at the same time. 
   
   
       14 . A kit comprising in one or more containers:
 (a) 2xCon4(C), and   (b) AMG 706 or 4TBPPAPC   
     or a salt of any or all thereof. 
   
   
       15 . A kit according to  claim 14 , comprising 2xCon4(C) and AMG 706. 
   
   
       16 . A kit according to  claim 14 , comprising 2xCon4(C) and 4TBPPAPC. 
   
   
       17 . A kit according to  claim 14 , comprising a pharmaceutically acceptable formulation of any or all of 2xCon4(C), 4TBPPAPC, or AMG 706. 
   
   
       18 . A kit according to  claim 14 , wherein (a) and (b) are disposed therein in one or more containers in a unit dose or an integral multiple of a unit dose. 
   
   
       19 . A kit according to  claim 14 , wherein (a) and (b) are comprised in formulations acceptable for use in treating diseases in humans. 
   
   
       20 . A kit according to  claim 11 , comprising a pharmaceutically acceptable salt of (a) or (b). 
   
   
       21 . A kit according to  claim 14 , further comprising a sterile diluent. 
   
   
       22 . A kit according to  claim 14 , further comprising information on the contents of the kit and on the nature and proper use of (a) and (b). 
   
   
       23 . A method according to  claim 6 , wherein the disease is cancer. 
   
   
       24 . A method according to  claim 23 , wherein the disease is colon cancer. 
   
   
       25 . A method according to  claim 6  wherein AMG 706 is administered at a dose of about 25 mg to about 125 mg once a day. 
   
   
       26 . A kit according to  claim 14 , wherein (a) and (b) are disposed in one or more containers for sequential administration in any order. 
   
   
       27 . A kit according to  claim 26 , further comprising information for said sequential administration. 
   
   
       28 . A kit according to  claim 27 , wherein one or both of (a) and (b) each are disposed therein in one or more containers in a unit dose or a multiple of a unit dose.