US2009304824A1PendingUtilityA1

Rapid-Melt Compositions, Methods of Making Same and Methods of Using Same

71
Assignee: CAPRICORN PHARMA INCPriority: Jul 5, 2000Filed: Mar 24, 2009Published: Dec 10, 2009
Est. expiryJul 5, 2020(expired)· nominal 20-yr term from priority
Inventors:S. Cherukuri
A61K 31/09A61K 9/0056A61K 31/137A61K 31/351A61K 31/375A61K 31/60A61K 31/726
71
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Claims

Abstract

A novel rapid-melt composition, including methods of making the same, and methods of using the same for the delivery of prophylactic and therapeutic active materials to a mammal. The rapid-melt compositions are formed by molding or compression, with an additional heating step being preferred.

Claims

exact text as granted — not AI-modified
1 . A rapid-melt compressed solid pharmaceutical composition comprising:
 at least one binder in an amount from about 0.01% to about 70% by weight;   a salivating agent in an amount from about 0.05% to about 15% by weight;   a diluent/bulking material in an amount from about 10% to about 90% by weight; and   a mineral salt.   
   
   
       2 . The composition of  claim 1 , wherein the diluent/bulking material is manitol. 
   
   
       3 . The composition of  claim 1 , wherein the diluent/bulking material is dextrate. 
   
   
       4 . The composition of  claim 1 , wherein the mineral salt is zinc acetate. 
   
   
       5 . The composition of  claim 1 , wherein the mineral salt is zinc gluconate. 
   
   
       6 . The composition of  claim 1 , further comprising vitamin C. 
   
   
       7 . The composition of  claim 4 , further comprising  Echinacea.    
   
   
       8 . The composition of  claim 1 , wherein the salivating agent is an emulsifier. 
   
   
       9 . The composition of  claim 8 , wherein the emulsifier is sodium lauryl sulfate. 
   
   
       10 . The composition of  claim 8 , wherein the emulsifier is polysorbate 80. 
   
   
       11 . The composition of  claim 1 , wherein the binder is polyethylene glycol. 
   
   
       12 . The composition of  claim 1 , wherein the diluent/bulking material further comprising magnesium stearate. 
   
   
       13 . The composition of  claim 1 , further comprising a sweetener. 
   
   
       14 . A rapid-melt compressed solid pharmaceutical composition comprising crosspovidone, mannitol, stearic acid, and a mineral salt. 
   
   
       15 . The composition of  claim 14 , wherein the mineral salt is zinc acetate. 
   
   
       16 . The composition of  claim 14 , wherein the mineral salt is zinc gluconate. 
   
   
       17 . The composition of  claim 14 , further comprising vitamin C. 
   
   
       18 . The composition of  claim 14 , further comprising  Echinacea.    
   
   
       19 . The composition of  claim 14 , further comprising a sweetener. 
   
   
       20 . A rapid-melt compressed solid pharmaceutical composition comprising polyethylene glycol, an emulsifier, a lubricant, and a mineral salt. 
   
   
       21 . The composition of  claim 20 , wherein the mineral salt is zinc acetate. 
   
   
       22 . The composition of  claim 20 , wherein the mineral salt is zinc gluconate. 
   
   
       23 . The composition of  claim 20 , wherein the emulsifier is sodium lauryl sulfate. 
   
   
       24 . The composition of  claim 20 , wherein the lubricant is magnesium stearate. 
   
   
       25 . The composition of  claim 20 , further comprising a sweetener. 
   
   
       26 . The composition of  claim 20 , further comprising a flavoring agent.

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