Bi-lateral local renal delivery for treating congestive heart failure and for bnp therapy

Abstract

The invention relates to systems and methods for local renal delivery of agents to subjects that are at risk for congestive heart failure and other conditions. The invention encompasses devices for renal drug delivery and method of use.

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       12 . A method comprising:
 positioning an intravascular catheter through an aorta so that at least one delivery port is positioned in at least one renal artery; and   delivering an active substance through said intravascular catheter to said at least one renal artery;   wherein the catheter comprises a bifurcated distal end and a body having a compliant region which accommodates tension or compression resulting from patient movement when the catheter is positioned in the aorta and the delivery port is in the at least one renal artery.   
   
   
       13 . A method as in  claim 12 , wherein the compliant region is non-linear and comprises a coil structure, a serpentine structure, or a zig-zag structure. 
   
   
       14 . A method as in  claim 12 , wherein the complaint region has a stiffness less that than of adjacent regions to permit slackness in the region after deployment in the aorta. 
   
   
       15 . A method as in  claim 14 , wherein the positioning comprises:
 straightening the compliant region with a stylet disposed within a lumen of the catheter;   advancing the catheter through the aorta while the catheter remains straightened with the stylet; and   withdrawing the stylet from the compliant region to allow the compliant region to assume its non-linear configuration.   
   
   
       16 . A method as in  claim 15 , wherein the active substance comprises a natriuretic peptide. 
   
   
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       18 . A method as in  claim 15 , wherein the active substance is delivered in bolus form. 
   
   
       19 . A method as in  claim 15 , wherein the active substance is delivered via continuous administration. 
   
   
       20 . A method as in  claim 15 , wherein the active substance is delivered through a bolus form in combination with continuous administration. 
   
   
       21 . A renal drug delivery catheter, said catheter comprising:
 a catheter body having a proximal end, a bifurcated distal end, and a drug delivery lumen therethrough; and   a hub on the proximal end adapted to deliver drugs to the drug delivery lumen;   wherein the distal end of the catheter body is adapted to enter a renal artery when the catheter body is located in an adjacent aorta; and   wherein a portion of the catheter body is compliant to accommodate tension or compression resulting from patient movement when the catheter body is in the aortic and the distal end is in the renal artery.   
   
   
       22 . A renal drug delivery catheter as in  claim 21 , wherein said portion is non-linear and has a coil, serpentine, or zig-zag geometry over a length. 
   
   
       23 . A renal drug delivery catheter as in  claim 21 , wherein the compliant section has a stiffness that is less than that of adjacent regions of the catheter so that the complaint section is slack and can be loosely deployed to accommodate tension and elongation after placement. 
   
   
       24 . A renal drug delivery catheter as in  claim 21 , further comprising a stylet which can be placed in a lumen during delivery to straighten the compliant portion. 
   
   
       25 . A method as in  claim 15 , wherein the active substance comprises a synthetically manufactured substance. 
   
   
       26 . A method as in  claim 15 , wherein the active substance comprises a naturally derived substance.