Method and composition for removing uremic toxins in dialysis processes

Abstract

Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.

1 . A cartridge for regenerating dialysis solution comprising: a layer for removing uremic waste from said dialysis solution; a urea removal layer that rejects calcium and magnesium ions; and an ion-exchange layer for removing at least phosphate from said dialysis solution. 
   
   
       2 . The cartridge of  claim 1  wherein the layer for removing uremic waste comprises activated carbon. 
   
   
       3 . The cartridge of  claim 1  wherein the ion-exchange layer is comprised on an ion-exchange resin. 
   
   
       4 . The cartridge of  claim 1  wherein the urea removal layer further comprises:
 an enzyme to degrade the urea; and   an ion-exchange sorbent to absorb the urea degradation products.   
   
   
       5 . The cartridge of  claim 4  wherein the enzyme to degrade the urea is urease. 
   
   
       6 . The cartridge of  claim 4  wherein the ion exchange sorbent is a zirconium phosphate resin. 
   
   
       7 . The cartridge of  claim 1  wherein the dialysis solution is peritoneal dialysis solution. 
   
   
       8 . The cartridge of  claim 1 , wherein the layer for removing uremic waste removes uremic waste selected from the group consisting of creatinine, uric acid, and combinations thereof. 
   
   
       9 . (canceled) 
   
   
       10 . The cartridge of  claim 1 , wherein the ion-exchange layer further removes sodium.