US2009317821A1PendingUtilityA1

Methods and compositions for identifying individuals at reduced risk of sepsis

66
Assignee: UNIV DUKEPriority: Dec 13, 2004Filed: Jul 23, 2009Published: Dec 24, 2009
Est. expiryDec 13, 2024(expired)· nominal 20-yr term from priority
Inventors:Debra A. SchwinnDaniel LaskowitzMihai V. PodgoreanuEugene W. Moretti
C12Q 2600/156C12Q 2600/118C12Q 1/6883
66
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Claims

Abstract

The present invention provides a method of identifying a subject having a reduced risk of developing sepsis, comprising detecting at least one APOE3 allele in nucleic acid from the subject.

Claims

exact text as granted — not AI-modified
1 - 8 . (canceled) 
     
     
         9 . A primer pair for detecting an APOE3 allele in a nucleic acid sample, wherein the primer pair consists of an oligonucleotide comprising the nucleotide sequence 
       
         
           
                 
                 
                 
               
                     
                   5′TAAGCTTGGCACGGCTGTCCAAGGA3′ 
                   (SEQ ID NO: 1) 
                 
             
                
               
            
           
         
       
       and an oligonucleotide comprising the nucleotide sequence 
       
         
           
                 
                 
               
                   5′ACAGAATTCGCCCCGGCCTGGTACACTGCCA3′. 
                   {SEQ ID NO: 2) 
                 
             
                
               
            
           
         
       
     
     
         10 . A kit for detecting an APOE3 allele in a nucleic acid sample, comprising the primer pair of  claim 9  and reagents for detection of nucleic acid.

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