US2009318490A1PendingUtilityA1
Compounds and methods for promoting smoking cessation
Est. expiryNov 8, 2020(expired)· nominal 20-yr term from priority
Inventors:F. Ivy Carroll
A61P 43/00A61P 25/34A61P 25/00A61P 25/18A61P 3/04A61P 25/22A61P 25/28A61P 25/16A61P 25/04A61P 25/24A61P 25/08A61P 1/04C07D 487/22A61K 31/4439A61K 31/44
65
PatentIndex Score
0
Cited by
0
References
0
Claims
Abstract
Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states.
Claims
exact text as granted — not AI-modified1 - 71 . (canceled)
72 . A method of treating depression, comprising administering to a patient in need thereof an effective amount of a compound represented by formula (II):
wherein
A 3 is —R, —N(R) 2 , —C(═NR)N(R) 2 , or —OR;
each Q is, independently, C—X or N, wherein one Q is N and each other Q is C—X;
each X is, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN, with the proviso that at least one X is represented by the formula:
each S is, independently, halogen, alkyl, alkenyl, alkynyl, phenyl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN, or two S, taken together with the phenyl group to which they are bonded, form a 2-naphthyl group;
c is 1, 2, 3, 4 or 5;
Y is a halogen; and
each R is, independently, H, alkyl, alkenyl, alkynyl, aryl, or aralkyl;
or a pharmaceutically acceptable salt thereof.
73 . The method of claim 72 , wherein c is 1.
74 . The method of claim 72 , wherein c is 2.
75 . The method of claim 72 , wherein c is 3.
76 . The method of claim 72 wherein two of said S, taken together with the phenyl group to which they are bonded, form a 2-naphthyl group.
77 . The method of claim 72 , wherein c is 1, 2, 3, 4, or 5, and at least one S is halogen, alkyl, alkenyl, alkynyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN, wherein R and Y are as defined in claim 72 .
78 . The method of claim 72 , wherein c is 1, 2, 3, 4, or 5, and at least one S is halogen, alkyl, or —NO 2 .
79 . The method of claim 72 , wherein c is 1, 2, or 3, and at least one S is halogen, alkyl, or —NO 2 .
80 . The method of claim 72 , wherein c is 1 or 2, and at least one S is halogen, alkyl, or —NO 2 .
81 . The method of claim 72 , wherein at least one X is halogen or —NH 2 .
82 . The method of claim 72 , wherein at least one X is halogen, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN, wherein R is as defined in claim 72 .
83 . The method of claim 72 , wherein A 3 is H or alkyl.
84 . The method of claim 72 , wherein A 3 is H.
85 . The method of claim 72 , wherein one Q is N.
86 . The method of claim 72 , wherein each X is independently selected from the group consisting of H, F, Cl, Br, l, CH 3 , OH, NH 2 , (CH 3 ) 2 N, NHAc, CF 3 SO 3 , subject to said proviso.
87 . The method of claim 72 , wherein R is H, alkyl or benzyl.
88 . The method of claim 72 , wherein said alkyl group in the definition of R is represented by the formula —(CH 2 ), —Y, wherein Y is a halogen and n is an integer from 1 to 8.
89 . The method of claim 72 , wherein the compound is represented by formula (IIa):
wherein
A 3 is as defined in claim 72 ;
X 1 , X 2 , X 3 and X 4 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN, wherein at least one of X 1 , X 2 , X 3 , and X 4 is represented by said formula:
wherein
S and c are as defined in claim 72 ;
Y is as defined in claim 72 ; and
R is as defined in claim 72 .
90 . The method of claim 89 , wherein the compound is represented by formula (IIb):
wherein
A 3 is as defined in claim 89 ;
X 1 , X 3 and X 4 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
R is as defined in claim 89 ;
Y is as defined in claim 89 ;
S is as defined in claim 89 ; and
c is as defined in claim 89 .
91 . The method of claim 90 , wherein c is 1.
92 . The method of claim 90 , wherein c is 2.
93 . The method of claim 90 , wherein c is 3.
94 . The method of claim 90 , wherein two of said S, taken together with the phenyl group to which they are bonded, form a 2-naphthyl group.
95 . The method of claim 90 , wherein c is 1, 2, 3, 4, or 5, and at least one S is halogen, alkyl, alkenyl, alkynyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN, wherein R and Y are as defined in claim 90 .
96 . The method of claim 90 , wherein c is 1, 2, 3, 4, or 5, and at least one S is halogen, alkyl, or —NO 2 .
97 . The method of claim 90 , wherein c is 1, 2, or 3, and at least one S is halogen, alkyl, or —NO 2 .
98 . The method of claim 90 , wherein c is 1 or 2, and at least one S is halogen, alkyl, or —NO 2 .
99 . The method of claim 90 , wherein at least one of X 1 , X 3 , and X 4 is halogen or —NH 2 .
100 . The method of claim 90 , wherein at least one of X 1 , X 3 , and X 4 is halogen, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN, wherein R is as defined in claim 90 .
101 . The method of claim 90 , wherein A 3 is H or alkyl.
102 . The method of claim 90 , wherein A 3 is H.
103 . The method of claim 90 , wherein X 1 , X 3 , and X 4 are each hydrogen.
104 . The method of claim 90 , wherein R is H, alkyl or benzyl.
105 . The method of claim 90 , wherein said alkyl group in the definition of R is represented by the formula —(CH 2 ) n —Y, wherein Y is a halogen and n is an integer from 1 to 8.
106 . The method of claim 90 , wherein X 1 is fluorine and X 3 and X 4 are hydrogen.
107 . The method of claim 106 , wherein c is 1.
108 . The method of claim 107 , wherein S is fluorine, chlorine, methoxy, —NO 2 or —NH 2 .
109 . The method of claim 108 , wherein A 3 is hydrogen.
110 . The method of claim 90 , wherein X 1 is —Cl, —Br, NH 2 or OH and X 3 and X 4 are hydrogen.
111 . The method of claim 110 , wherein c is 1.
112 . The method of claim 111 , wherein S is —Cl, —Br, —F, —NO 2 , methoxy, —NH 2 or N(CH 3 ) 3 .
113 . The method of claim 112 , wherein A 3 is hydrogen.
114 . The method of claim 72 , wherein at least one atom in the compound is a member selected from the group consisting of 3 H, 11 C, 14 C, 35 S, 18 F, 123 I, 125 I, and 131 I.
115 . The method of claim 114 , wherein at least one atom in the compound is a member selected from the group consisting of 3 H, 11 C, 18 F, and 123 I.
116 . The method of claim 114 , wherein at least one X is 18 F, 123 I, 125 I, or 131 I.
117 . The method of claim 114 , wherein at least one X is a phenyl group substituted with one or more of 18 F, 123 I, 125 I, or 131 I.Join the waitlist — get patent alerts
Track US2009318490A1 — get alerts on status changes and closely related new filings.
We store only your email — no account needed. See our privacy policy.