Antimicrobial And Sporicidal Composition

Abstract

Germicidal compositions with enhanced activity towards killing microbiological spores and vegetative cells comprising certain quaternary ammonium compounds (QACs), phenolic compounds, monohydric alcohols, hydrogen peroxide, iodine, triclocarban, triclosan or combinations thereof with one or more spore coat opening agents. The invention also provides for the application of the germicidal compositions to animate and inanimate surfaces to help kill germs and protect against the risk of infection from bacteria, molds, yeasts, fungi, viruses, and microbiological spores.

1 . A germicidal composition with enhanced microbiocidal activities for killing or disinfecting microbiological spores, microbiological outgrowth from spores and vegetative microorganisms comprising 0.05% to 10% of at least one quaternary ammonium compound selected from the group consisting of a quaternary ammonium compound containing a C 18-30  alkyl substituent, benzethonium chloride, benzethonium bromide, benzethonium iodide, methylbenzethonium chloride, methylbenzethonium bromide and methylbenzethonium iodide. 
   
   
       2 . A germicidal composition with enhanced microbiocidal activities for killing or inhibiting microbiological spores, microbiological outgrowth from spores and vegetative microorganisms comprising:
 at least one active sporicidal agent selected from the group consisting of: (1) a quaternary ammonium compound selected from the group consisting of benzethonium chloride or bromide, methylbenzethonium chloride or bromide, benzalkonium chloride or bromide, a C 8-24  mono-alkyl quaternary ammonium chloride or bromide, and a C 8-24  di-alkylquaternary ammonium chloride or bromide; (2) a phenolic compound selected from the group consisting of phenol, para-chlorometaxylenol, cresol and hexylresorcinol; (3) a compound selected from the group consisting of triclocarban, triclosan; a monohydric alcohol, hydrogen peroxide and iodine; and   at least one spore coat opener selected from the group consisting of: (1) an amino acid or a salt form of an amino acid; (2) a metal chelation agent selected from the group consisting of EDTA, EGTA, picolinic acid, niacin, citric acid, ascorbic acid, glutamic acid, and fulvic acid; and (3) a reducing agent selected from the group consisting of ascorbic acid, quinone, polyphenol, proanthocyanidin, and their salts.   
   
   
       3 . The germicidal composition of  claim 2  wherein the sporicidal agent is at least one quaternary ammonium compound selected from the group consisting of benzethonium chloride or bromide, methylbenzethonium chloride or bromide, benzalkonium chloride or bromide, a C 8-24  mono-alkyl quaternary ammonium chloride or bromide, and a C 8-24  di-alkylquaternary ammonium chloride or bromide, and the spore coat opener is a member selected from the group consisting of an amino acid, picolinic acid, niacin, citric acid, ascorbic acid, quinone, polyphenol, proanthocyanidin and their salts. 
   
   
       4 . The germicidal composition of  claim 3  wherein the sporicidal agent is at least one member selected from the group consisting of phenol, para-chlorometaxylenol, cresol, hexylresorcinol, triclocarban, a monohydric alcohol, hydrogen peroxide and iodine. 
   
   
       5 . A germicidal composition with enhanced microbiocidal activities for killing or disinfecting microbiological spores, microbiological outgrowth from spores and vegetative microorganisms comprising:
 at least one active sporicidal agent selected from the group consisting of: (1) a quaternary ammonium compound selected from the group consisting of benzethonium chloride or bromide, methylbenzethonium chloride or bromide, benzalkonium chloride or bromide, a C 8-24  mono-alkyl quaternary ammonium chloride or bromide, and a C 8-24  di-alkylquaternary ammonium chloride or bromide; (2) a phenolic compound selected from the group consisting of phenol, para-chlorometaxylenol, cresol and hexylresorcinol; and (3) a compound selected from the group consisting of triclocarban, triclosan, a monohydric alcohol, hydrogen peroxide, and iodine;   at least one spore coat opener selected from the group consisting of: (1) an amino acid or a salt form of an amino acid; (2) a metal chelation agent selected from the group consisting of EDTA, EGTA, picolinic acid, niacin, citric acid, ascorbic acid, glutamic acid, and fulvic acid, and their salts; and (3) a reducing agent selected from the group consisting of ascorbic acid, quinone, polyphenol, proanthocyanidin, and their salts;   at least one hydrophobic component selected from the group consisting of petrolatum, mineral oil, dimethicone, and synthetic or naturally occurring oils; and   at least one emollient or solubilizer selected from the group consisting of C 12-24  monohydric alcohols, C 2-18  monohydrohyric alcohol ethoxylates, C 8-24  alkylamine oxides, silicone copolyols, behentrimethylammonium methosulfate, behentrimethylammonium ethosulfate, behentrimethylammonium chloride, behentrimethylammonium bromide, babassuamindopropalkonium chloride, babassuamindopropalkonium bromide, benzethonium chloride or bromide, benzalkonium chloride or bromide, a C 8-24  mono-alkylquaternary ammonium chloride or bromide, and a C 8-24  di-alkylquaternary ammonium chloride or bromide.   
   
   
       6 . The germicidal composition of  claim 5  wherein the sporicidal agent is at least one quaternary ammonium compound selected from the group consisting of benzethonium chloride or bromide, methylbenzethonium chloride or bromide, benzalkonium chloride or bromide, a C 8-24  mono-alkyl quaternary ammonium chloride or bromide, and a C 8-24  di-alkylquaternary ammonium chloride or bromide, and the spore coat opener is a member selected from the group consisting of an amino acid, picolinic acid, niacin, citric acid, ascorbic acid, glutamic acid, fulvic acid, quinone, polyphenol, proanthocyanidin and their salts. 
   
   
       7 . The germicidal composition of  claim 5  wherein the sporicidal agent is at least one member selected from the group consisting of phenol, para-chlorometaxylenol, cresol, hexylresorcinol, triclocarban, triclosan; a monohydric alcohol, hydrogen peroxide and iodine. 
   
   
       8 . A method for disinfecting surfaces and killing microbiological spores, microbiological outgrowth from spores, and vegetative microorganisms comprising the step of applying the composition of  claim 1  to a surface. 
   
   
       9 . The method of  claim 8 , wherein the surface is a member selected from the group consisting of epithelial tissues, skin, fingernails, toenails, hair, mammary glands, perineal region, genitalia, rectum and mucosal linings. 
   
   
       10 . The method of  claim 8 , wherein the surface is an inanimate surface. 
   
   
       11 . The method of  claim 8 , wherein the composition is applied to the surface in the form of a spray, dipping solution, foam, lotion, cream, handwash, or wet wipe. 
   
   
       12 . A method for disinfecting surfaces and killing microbiological spores, microbiological outgrowth from spores, and vegetative microorganisms comprising the step of applying the composition of  claim 5  to a surface. 
   
   
       13 . The method of  claim 12 , wherein the surface is a member selected from the group consisting of epithelial tissues, skin, fingernails, toenails, hair, mammary glands, perineal region, genitalia, rectum and mucosal linings. 
   
   
       14 . The method of  claim 12 , wherein the surface is an inanimate surface. 
   
   
       15 . The method of  claim 12 , wherein the composition is applied to the surface in the form of a spray, dipping solution, foam, lotion, cream, handwash, or wet wipe.