US2009325939A1PendingUtilityA1
1h-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof

Assignee: XIE WENGEPriority: May 7, 2004Filed: Sep 3, 2009Published: Dec 31, 2009
Est. expiryMay 7, 2024(expired)· nominal 20-yr term from priority
Inventors:Wenge Xie Brian Herbert Richard Schumacher Jianguo Ma True Minh Nguyen Carla Gauss Ashok Tehim
A61P 9/10A61P 43/00A61P 9/00A61P 3/10C07D 487/08A61P 25/14A61P 25/18A61P 25/04A61P 25/00A61P 25/24C07D 471/08A61P 25/28A61P 25/22A61P 31/04A61P 3/04A61P 25/16A61P 25/30A61P 29/00A61P 25/32A61K 31/4985
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References
Claims
Abstract

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
Claims

exact text as granted — not AI-modified
1 . A compound selected from Formulas I, II, III, V, V, VI, VII and VIII: 
       
         
           
           
               
               
           
         
       
       wherein
 X 1  is CH or CR 1 ; 
 X 2  to X 5  are each, independently, N, CH, CR 1 , or C—, wherein —C represents the point of attachment of group B, and wherein at most one of X 2  to X 5  is N, and one of X 2  to X 5  is —C; 
 X 7  to X 10  are each, independently, N, CH, or CR 2 , wherein at most one of X 7  to X 10  is N; 
 X 11  to X 14  are each, independently N, CH, CR 3 , or C—, wherein —C represents the point of attachment of group B, and wherein at most one of X 11  to X 14  is N, and one of X 11  to X 14  is —C; 
 X 15  to X 17  are each, independently N, O, S, CH, or CR 4 ; 
 X 18  to X 21  are each, independently N, CH, or CR 5 , wherein at most one of X 18  to X 21  is N; 
 X 22  and X 23  are each, independently, CH or CR 12 , wherein at least one of X 22  or X 23  is CR 12 ; 
 X 24  is either CH or N; 
 B is CH 2 , C═O, or C═S; 
 B 1  is CH; 
 Y is O or S; 
 Z is O or NR 11 ; 
 m is 1 or 2; 
 R is H, alkyl having 1 to 4 carbon atoms, halogenated alkyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, cycloalkylalkyl having 4 to 7 carbon atoms, or C 1-6 alkyl-Ar, 
 R 1 , R 2 , R 4  and R 5  are each, independently,
 C 1-6 -alkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkenyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkynyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Si(R 8 ) 3 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 4-10 -cycloalkylalkyl which is unsubstituted or substituted in the cycloalkyl portion one or more times by F, Cl, Br, I, CN, OR 16 , NR 16 R 6 , SH, SR 7 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, and/or substituted in 
 the alkyl portion one or more times by one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 halogen, 
 CN, NO 2 , NR 6 R 7 , SR 6 , SOR 6 , SO 2 R 6 , SO 2 NR 6 R 7 , NR 6 SO 2 R 6 , CONR 6 R 7 , CSNR 6 R 7 , COOR 6 , NR 6 COR 7 , NR 6 CSR 7 , NR 6 CONR 6 R 7 , NR 6 CSNR 6 R 7 , NR 6 COOR 7 , NR 6 CSOR 7 , OCONR 6 R 7 , OCSNR 6 R 7 , 
 Ar, 
 Het, or 
 OR 9 ; 
 
 R 3  is halogen, OR 16 , CN, nitro, alkyl having 1 to 4 carbon atoms, halogenated alkyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, cycloalkylalkyl having 4 to 7 carbon atoms, hydroxyalkyl having 1 to 4 carbon atoms, NH 2 , monoalkylamino having 1 to 4 carbon atoms, dialkylamino wherein each alkyl group independently has 1 to 4 carbon atoms, Ar or Het; 
 R 6  and R 7  are each independently
 H, 
 C 1-6 -alkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, 
 C 3-6 -alkenyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, 
 C 3-6 -alkynyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Si(R 8 ) 3 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, 
 C 4-10 -cycloalkylalkyl which is unsubstituted or substituted in the cycloalkyl portion one or more times by F, Cl, Br, I, CN, OR 16 , monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, and/or substituted in the alkyl portion one or more times by one or more times by F, Cl, Br, I, CN, OR 16 , monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, 
 Ar, or 
 
 Het; 
 R 8  is C 1-6 -alkyl; 
 R 9  is H,
 C 1-6 -alkyl which is unsubstituted or substituted one or more by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-6 -alkenyl which is unsubstituted or substituted one or more by F, Cl, Br, I, CN, OR 16 , 
 NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-6 -alkynyl which is unsubstituted or substituted one or more by F, Cl, Br, I, CN, OR 16 NR 6 R 6 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 4-8 -cycloalkylalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 Ar, or 
 Het; 
 
 R 10  is H, alkyl having 1 to 4 carbon atoms, halogenated alkyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, or cycloalkylalkyl having 4 to 7 carbon atoms; 
 R 11  is H, alkyl having 1 to 4 carbon atoms which is unsubstituted or substituted one or more times by halogen, OR 16 , C 3-8  cycloalkyl, NR 6 R 7 , Ar, or Het, cycloalkyl having 3 to 7 carbon atoms which is unsubstituted or substituted one or more times by halogen, OR 16 , NR 6 R 7 , Ar, or Het, cycloalkylalkyl having 4 to 7 carbon atoms, Ar or Het; 
 R 12  is C 1-6 -alkoxy which is substituted one or more times by F, or is selected from Formulae IX-XI 
 
       
         
           
           
               
               
           
         
       
       wherein Formula IX represents a 5-membered, unsaturated heterocycle, Formula X represents a 5-8-membered, heterocycle which is saturated or partially saturated and wherein the heterocyclic ring may be bridged by a divalent alkylene group having 1 to 3 carbon atoms, and Formula XI represents a 5-8-membered, heterocycle which is saturated, partially saturated, or unsaturated and wherein the heterocyclic ring may be bridged by a divalent alkylene group having 1 to 3 carbon atoms;
 Q 1  is O, S, N, NR 13 , or SO 2 ; 
 Q is CH, CR 14 , CHR 14 , O, S, SO 2 , N, or NR 13 ; 
 T is O or NR 10 ; 
 V 1  is O, S, SO 2 , N, NR 13 , CR 13 , or CHR 14 ; 
 W 1  is N; 
 W 2  and W 3  are each, independently, O, S, N, NR 13 , CH, or CR 1 , in which the bond between W 2  and W 3  is a single bond and the bond between W 3  and W 4  is a double bond, or the bond between W 2  and W 3  is a double bond and the bond between W 3  and W 4  is a single bond; 
 W 4  is O, S, N, or NR 13 ; 
 V 2  is C, CH, C—OH, or N; 
 R 13  is H,
 C 1-6 -alkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-6 -alkenyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-6 -alkynyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Si(R 8 ) 3 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 4-10 -cycloalkylalkyl which is unsubstituted or substituted in the cycloalkyl portion one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 6 , SH, SR 7 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, and/or substituted in the alkyl portion one or more times by one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 SO 2 R 6 , CONR 6 R 7 , CSNR 6 R 7 , COOR 6 , CSOR 6 , COR 7 , CSR 7 , 
 Ar, or 
 Het; 
 
 R 14  is H,
 C 1-6 -alkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 9 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 7 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkenyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 9 , NR 7 R 6 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkynyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 9 , NR 7 R 6 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Si(R 8 ) 3 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 9 , NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 4-10 -cycloalkylalkyl which is unsubstituted or substituted in the cycloalkyl portion one or more times by F, Cl, Br, I, CN, OR 9 , NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, and/or substituted in the alkyl portion one or more times by one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 halogen, 
 CN, NO 2 , NR 6 R 7 , SR 6 , SOR 6 , SO 2 R 6 , SO 2 NR 6 R 7 , NR 6 SO 2 R 7 , CONR 6 R 7 , CSNR 6 R 7 , 
 COOR 6 , NR 6 COR 7 , NR 6 CSR 7 , NR 6 CONR 6 R 7 NR 6 CSNR 7 R 6 NR 7 COOR 6 , NR 7 CSOR 6 , OCONR 6 R 7 , OCSNR 6 R 7 , 
 Ar, 
 Het, or 
 OR 9 ; 
 
 R 15  is H,
 C 1-6 -alkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkenyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkynyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Si(R 8 ) 3 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 4-10 -cycloalkylalkyl which is unsubstituted or substituted in the cycloalkyl portion one or more times by F, Cl, Br, I, CN, OR 16 , NR 16 R 6 , SH, SR 7 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, and/or substituted in the alkyl portion one or more times by one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyloxy which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 halogen, 
 oxo, thio, CN, NO 2 , NR 6 R 7 , SR 6 , SOR 6 , SO 2 R 6 , SO 2 NR 6 R 7 , NR 6 SO 2 R 7 , CONR 6 R 7 , CSNR 6 R 7 , COOR 6 , NR 6 COR 7 , NR 6 CSR 7 , NR 6 CONR 6 R 7 , NR 6 CSNR 6 R 7 , NR 6 COOR 7 , NR 6 CSOR 7 , OCONR 6 R 7 , OCSNR 6 R 7 , 
 Ar, 
 Het, or 
 OR 9 ; 
 
 R 16  is H,
 C 1-6 -alkyl which is unsubstituted or substituted one or more by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, or 
 C 4-8 -cycloalkylalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 7 R 6 , Ar, Het, or combinations thereof; 
 
 Ar is an aryl group containing 6 to 10 carbon atoms which is unsubstituted or substituted one or more times by
 alkyl having 1 to 8 carbon atoms, 
 alkoxy having 1 to 8 carbon atoms, 
 halogen, 
 amino, 
 cyano, 
 hydroxyl, 
 nitro, 
 halogenated alkyl having 1 to 8 carbon atoms, 
 halogenated alkoxy having 1 to 8 carbon atoms, 
 hydroxyalkyl having 1 to 8 carbon atoms, 
 hydroxyalkoxy having 2 to 8 carbon atoms, 
 alkenyloxy having 3 to 8 carbon atoms, 
 monoalkylamino having 1 to 8 carbon atoms, 
 dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, 
 carboxy, 
 alkoxycarbonyl, 
 alkylaminocarbonyl, 
 acylamido, 
 acyloxy, 
 alkylthio having 1 to 8 carbon atoms, 
 alkylsulphinyl having 1 to 8 carbon atoms, 
 alkylsulphonyl having 1 to 8 carbon atoms, 
 sulfo, 
 sulfonylamino, 
 Het, 
 cycloalkylamino wherein the cycloalkyl group has 3 to 7 C atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 aryloxy wherein the aryl portion contains 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 arylthio wherein the aryl portion contains 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 cycloalkyloxy wherein the cycloalkyl group has 3 to 7 C atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, or combinations thereof; and 
 
 Het is a heterocyclic group, which is fully saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is a N, O or S atom, which is unsubstituted or substituted one or more times by
 alkyl having 1 to 8 carbon atoms, 
 alkoxy having 1 to 8 carbon atoms, 
 halogen, 
 amino, 
 cyano, 
 hydroxyl, 
 nitro, 
 halogenated alkyl having 1 to 8 carbon atoms, 
 halogenated alkoxy having 1 to 8 carbon atoms, 
 hydroxyalkyl having 1 to 8 carbon atoms, 
 hydroxyalkoxy having 2 to 8 carbon atoms, 
 alkenyloxy having 3 to 8 carbon atoms, 
 monoalkylamino having 1 to 8 carbon atoms, 
 dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, 
 carboxy, 
 alkoxycarbonyl, 
 alkylaminocarbonyl, 
 acylamido, 
 acyloxy, 
 alkylthio having 1 to 8 carbon atoms, 
 alkylsulphinyl having 1 to 8 carbon atoms, 
 alkylsulphonyl having 1 to 8 carbon atoms, 
 sulfo, 
 oxo, 
 sulfonylamino, 
 cycloalkylamino wherein the cycloalkyl group has 3 to 7 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 aryl containing 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 aryl-alkylene group wherein the aryl portion contains 6 to 10 carbon atoms and the alkylene portion contains 1 to 4 carbon atoms and is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 8 C atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 aryloxy wherein the aryl portion contains 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 arylthio wherein the aryl portion contains 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 cycloalkyloxy wherein the cycloalkyl group has 3 to 7 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 C carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 heterocyclic group, which is fully saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is a N, O or S atom, which is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, or combinations thereof; and 
 
 
       pharmaceutically acceptable salts thereof; 
       wherein when said compound is of Formulas I, II, V, VI, VII or VII, VIII is 1. 
     
     
         2 . A compound according to  claim 1 , wherein said compound is of Formula I. 
     
     
         3 . A compound according to  claim 1 , wherein said compound is of Formula II. 
     
     
         4 . A compound according to  claim 1 , wherein said compound is of Formula III. 
     
     
         5 . A compound according to  claim 1 , wherein said compound is of Formula IV. 
     
     
         6 . A compound according to  claim 1 , wherein said compound is of Formula V. 
     
     
         7 . A compound according to  claim 1 , wherein said compound is of Formula VI. 
     
     
         8 . A compound according to  claim 1 , wherein said compound is of Formula VII. 
     
     
         9 . A compound according to  claim 1 , wherein said compound is of Formula VIII. 
     
     
         10 . A compound according to  claim 1 , wherein R in Formulas I and VI is H. 
     
     
         11 . A compound according to  claim 1 , wherein said compound is selected from Formulas I-VI in which
 R is H, and   Het is a heterocyclic group, which is fully saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is a N, O or S atom, which is unsubstituted or substituted one or more times by
 alkyl having 1 to 8 carbon atoms, 
 alkoxy having 1 to 8 carbon atoms, 
 halogen, 
 amino, 
 cyano, 
 hydroxyl, 
 nitro, 
 halogenated alkyl having 1 to 8 carbon atoms, 
 halogenated alkoxy having 1 to 8 carbon atoms, 
 hydroxyalkyl having 1 to 8 carbon atoms, 
 hydroxyalkoxy having 2 to 8 carbon atoms, 
 alkenyloxy having 3 to 8 carbon atoms, 
 monoalkylamino having 1 to 8 carbon atoms, 
 dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, 
 carboxy, 
 alkoxycarbonyl, 
 alkylaminocarbonyl, 
 acylamido, 
 acyloxy, 
 alkylthio having 1 to 8 carbon atoms, 
 alkylsulphinyl having 1 to 8 carbon atoms, 
 alkylsulphonyl having 1 to 8 carbon atoms, 
 sulfo, 
 sulfonylamino, 
 cycloalkylamino wherein the cycloalkyl group has 3 to 7 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 aryl containing 6 to 10 carbon atoms which is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 aryl-alkylene group wherein the aryl portion contains 6 to 10 carbon atoms and the alkylene portion contains 1 to 4 carbon atoms and is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 8 C atoms, halogenated alkyl having 1 to 8 carbon atoms, 
 alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 aryloxy wherein the aryl portion contains 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 arylthio wherein the aryl portion contains 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 cycloalkyloxy wherein the cycloalkyl group has 3 to 7 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 heterocyclic group, which is fully saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is a N, O or S atom, which is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, or combinations thereof; 
   
       and pharmaceutically acceptable salts thereof. 
     
     
         12 . A compound according to  claim 1 , wherein said compound is selected from Formulas I-V, wherein
 R is H, and   R 1 R 2 , R 4  and R 5  are each, independently
 C 1-6 -alkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 7 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkenyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 7 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkynyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 7 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Si(R 8 ) 3 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 4-10 -cycloalkylalkyl which is unsubstituted or substituted in the cycloalkyl portion one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, and/or substituted in the alkyl portion one or more times by one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyloxy which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 7 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 halogen, 
 CN, NO 2 , NR 6 R 7 , SR 6 , SOR 6 , SO 2 R 6 SO 2 NR 6 R 7 , NR 6 SO 2 R 7 , CONR 6 R 7 , CSNR 6 R 7 , COOR 6 , NR 6 COR 7 , NR 6 CSR 7 , NR 6 CONR 7 R 6 , NR 7 CSNR 6 R 7 , NR 6 COOR 7 , NR 6 CSOR 7 , OCONR 6 R 7 , OCSNR 6 R 7 , 
 Ar, 
 Het, or 
 OR 9 ; 
   R 3  is halogen, OH, CN, nitro, alkyl having 1 to 4 carbon atoms, halogenated alkyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, cycloalkylalkyl having 4 to 7 carbon atoms, alkoxy having 1 to 4 carbon atoms, cycloalkoxy having 3 to 7 carbon atoms, cycloalkylalkoxy having 4 to 7 carbon atoms, halogenated alkoxy having 1 to 4 carbon atoms, hydroxyalkyl having 1 to 4 carbon atoms, hydroxyalkoxy having 2 to 4 carbon atoms, NH 2 , monoalkylamino having 1 to 4 carbon atoms, dialkylamino wherein each alkyl group independently has 1 to 4 carbon atoms, Ar or Het;   R 6  and R 7  are each independently
 H, 
 C 1-6 -alkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, 
 C 3-6 -alkenyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, 
 C 3-6 -alkynyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Si(R 8 ) 3 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, 
 C 4-10 -cycloalkylalkyl which is unsubstituted or substituted in the cycloalkyl portion one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, and/or substituted in the alkyl portion one or more times by one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, 
 Ar, or 
 Het; 
   R 9  is H,
 C 1-6 -alkyl which is unsubstituted or substituted one or more by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-6 -alkenyl which is unsubstituted or substituted one or more by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-6 -alkynyl which is unsubstituted or substituted one or more by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 7 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 4-8 -cycloalkylalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 Ar, or 
   Het; and   R 11  is H,   alkyl having 1 to 4 carbon atoms which is unsubstituted or substituted one or more times by halogen, OH, alkoxy having 1 to 4 carbon atoms, C 3-8  cycloalkyl, NR 6 R 7 , Ar, or Het,   cycloalkyl having 3 to 7 carbon atoms which is unsubstituted or substituted one or more times by halogen, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , Ar, or Het,
 Ar, or 
   Het.   
     
     
         13 . A compound according to  claim 1 , wherein said compound is selected from Formulas I, II, IV and V, and at least one of R 1 , R 2 , R 4  and R 5  is C 1-6 -alkyl which is substituted at least one time by OR 16 , C 2-16 -alkenyl which is substituted at least one time by OR 16 , C 2-6 -alkynyl which is substituted at least one time by OR 16 , C 3-8 -cycloalkyl which is substituted at least one time by OR 16 , or C 4-10 -cycloalkylalkyl which is substituted at least one time by OR 16 , and R 16  is other than H or C 1-4 -alkyl. 
     
     
         14 . A compound according to  claim 1 , wherein said compound is of Formula III, R 3  is OR 16 , and R 16  is other than H, C 1-4 -alkyl, halogenated C 1-4 -alkyl, C 3-7 -cycloalkyl or C 4-8 -cycloalkylalkyl. 
     
     
         15 . A compound according to  claim 1 , wherein said compound is selected from Formulas I, II, IV and V, and at least one of R 6  and R 7  is C 1-6 -alkyl which is substituted at least one time by OR 16 , C 3-6 -alkenyl which is substituted at least one time by OR 16 , C 3-6 alkynyl which is substituted at least one time by OR 16 , C 3-8 -cycloalkyl which is substituted at least one time by OR 16 , or C 4-10 -cycloalkylalkyl which is substituted at least one time by OR 16 , and R 16  is other than H or C 1-4 -alkyl. 
     
     
         16 . A compound according to  claim 1 , wherein said compound is selected from Formulas I, II, IV and V, and at least one R 9  is C 1-6 -alkyl which is substituted at least one time by OR 16 , C 3-6 -alkenyl which is substituted at least one time by OR 16 , C 3-6 -alkynyl which is substituted at least one time by OR 16 , C 3-8 -cycloalkyl which is substituted at least one time by OR 16 , or C 4-10 -cycloalkylalkyl which is substituted at least one time by OR 16 , and R 16  is other than H or C 1-4 -alkyl. 
     
     
         17 . A compound according to  claim 1 , wherein said compound is of Formula IV, Z is NR 11 , R 11  is C 1-4 -alkyl which is substituted at least one time by OR 16  or C 3-7 -cycloalkyl which is substituted at least one time by OR 16 , and R 16  is other than H or C 1-4 -alkyl. 
     
     
         18 . A compound according to  claim 1 , wherein
 R 1 , R 2 , R 2 , R 4 , R 5 , and R 14  are each, independently, halogen, nitro, NR 15 R 16 , amino, alkylamino, dialkylamino, unsubstituted or substituted phenyl, NR 6 CONR 6 R 7 , hydroxyl, alkoxy, halogenated alkoxy, or alkylsulfonamide;   R 3  is halogen, nitro, amino, alkylamino, dialkylamino, hydroxyl, alkoxy, or halogenated alkoxy; and   R 6 , R 7 , R 9 , and R 11  are each, independently, unsubstituted or substituted phenyl.   
     
     
         19 . A compound according to  claim 1 , wherein Ar is in each case phenyl, napthyl or biphenyl, which is unsubstituted or substituted one or more times by halogen, alkyl, hydroxy, alkoxy, nitro, amino, alkylamino, dialkylamino, hydroxyalkyl, hydroxyalkoxy, carboxy, cyano, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, phenoxy, or acyloxy. 
     
     
         20 . A compound according to  claim 1 , wherein Het is in each case tetrahydrofuranyl, tetrahydrothienyl, tetrahydropyranyl, dihydropyranyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, oxoazolinyl, isoxazolinyl, furyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, pyridyl, pyrimidinyl, benzopyranyl, indolyl, quinolinyl, isoquinolinyl or naphthyridinyl, which is unsubstituted or substituted one or more times by halogen, aryl, alkyl, hydroxy, alkoxy, cyano, trifluoromethyl, nitro, oxo, amino, alkylamino, or dialkylamino. 
     
     
         21 . A compound according to  claim 1 , wherein Het is in each case 2-quinolinyl, 1,3-benzodioxyl, 2-thienyl, 2-benzofuranyl, 2-benzothiophenyl, 3-thienyl, 2,3-dihydro-5-benzofuranyl, 4-indoyl, 4-pyridyl, 3-quinolinyl, 4-quinolinyl, 1,4-benzodioxan-6-yl, 3-indoyl, 2-pyrrolyl, benzopyran-6-yl, 5-indolyl, 1,5-benzoxepin-8-yl, 3-pyridyl, 6-coumarinyl, 5-benzofuranyl, 2-isoimidazol-4-yl, 3-pyrazolyl, 3-carbazolyl, 2-thiazolyl, 2-oxazolyl, 1-imidazolyl, or 2-imidazolyl, which is unsubstituted or substituted one or more times by halogen, aryl, alkyl, hydroxy, alkoxy, cyano, trifluoromethyl, nitro, oxo, amino, alkylamino, or dialkylamino. 
     
     
         22 . A compound according to  claim 1 , wherein the heterocyclic groups of Formulas IX-XI are selected from thiazolyl, substituted thiazolyl, thiazolylamino, substituted thiazolylamino, oxazolyl, substituted oxazolyl, imidazolyl, substituted imidazolyl, pyranyl, substituted pyranyl, piperidinyl, substituted piperidinyl, pyrrolydinyl, substituted pyrrolydinyl, pyrrolydinyloxy, and substituted pyrrolydinyloxy. 
     
     
         23 . A compound according to  claim 14 , wherein the heterocyclic groups of Formulas IX-XI are selected from 5-methyl-1,3-thiazol-2-yl, 4-methyl-1,3-thiazol-2-yl, 1,3-thiazol-2-yl, 1,3-oxazol-2-yl, 1,3-imidazol-2-yl, 5-methyl-1,3-oxazol-2-yl, 4-methyl-1,3-oxazol-2-yl, pyran-4-yl, piperidin-4-yl, pyrrolidin-3-yl, pyrrolidin-3-yloxy, 3-hydroxypyrrolidin-1-yl, and 1,3-thiazol-2-ylamino. 
     
     
         24 . A compound according to  claim 1 , wherein said compound is selected from Formulas II and VI, and B is C═O. 
     
     
         25 . A compound according to  claim 1 , wherein said compound is of Formula V, and B is CH 2  or C═O. 
     
     
         26 . A compound according to  claim 1 , wherein said compound is selected from Formulas IV and V, and Z is O or NH. 
     
     
         27 . A compound according to  claim 1 , wherein said compound is of Formula II and Y is S. 
     
     
         28 . A compound according to  claim 1 , wherein m is 2. 
     
     
         29 . A compound according to  claim 1 , wherein R 12  is of Formula IX, and is oxazolyl, thiazolyl, 4-methylthiazolyl, or 5-methylthiazolyl. 
     
     
         30 . A compound according to  claim 1 , wherein R 12  is of Formula X and is tetrahydropyran and dihydropyran. 
     
     
         31 . A compound according to  claim 1 , wherein R 12  is of Formula X and is 3-methyl-imidazolidin-2-one or 3-isopropyl-imidazolidin-2-one. 
     
     
         32 . A compound according to  claim 1 , wherein R 12  is fluorinated alkoxy. 
     
     
         33 . A compound according to  claim 1 , wherein R 12  is OCH 3 , OCF 3 , ethoxy, cyclopropylmethoxy, or cyclopropyl. 
     
     
         34 . A compound according to  claim 1 , wherein R 5  is OCH 3 . 
     
     
         35 . A compound according to  claim 1 , wherein said compound is of Formula VI. 
     
     
         36 . (canceled) 
     
     
         37 . (canceled) 
     
     
         38 . A compound according to  claim 1 , wherein said compound is selected from: 
       3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-1,2-benzisothiazole, 
       3-(1,4-Diazabicyclo [3.2.2]non-4-ylcarbonyl)-6-methoxy-1,2-benzisothiazole,
 pharmaceutically acceptable salts thereof. 
 
     
     
         39 . (canceled) 
     
     
         40 . A compound according to  claim 1 , wherein said compound is selected from: 
       3-(1,4-Diazabicyclo [3.2.2]non-4-ylcarbonyl)-1,2-benzisoxazole, 
       3-(1,4-Diazabicyclo [3.2.2]non-4-ylcarbonyl)-6-(ethoxy)-1,2-benzisothiazole, 
       3-(1,4-Diazabicyclo [3.2.2]non-4-ylcarbonyl)-6-(trifluoromethoxy)-1,2-benzisothiazole, 
       3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-7-(methoxy)-1,2-benzisothiazole, 
       6-(Cyclopropylmethoxy)-3-(1,4-diazabicyclo[3.2.2]non-4-ylcarbonyl)-1,2-benzisothiazole, 
       6-Cyclopropyl-3-(1,4-diazabicyclo[3.2.2]non-4-ylcarbonyl)-1,2-benzisothiazole,
 pharmaceutically acceptable salts thereof. 
 
     
     
         41 . A compound according to  claim 1 , wherein said compound is selected from: 
       3-(1,4-Diazabicyclo [3.2.2]non-4-ylcarbonyl)-1,2-benzisothiazol-6-ol, 
       3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-6-(methoxy)-1,2-benzisothiazole, 
       6-Bromo-3-(1,4-diazabicyclo[3.2.2]non-4-ylcarbonyl)-1,2-benzisothiazole, 
       1-[3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-1,2-benzisothiazol-6-yl]-3-isopropylimidazolidin-2-one, 
       1-[3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-1,2-benzisothiazol-6-yl]-3-methylimidazolidin-2-one,
 and pharmaceutically acceptable salts thereof. 
 
     
     
         42 . A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected from Formulas I, II, III, IV, V, VI, VII and VIII: 
       
         
           
           
               
               
           
         
         wherein 
         X 1  is CH or CR 1 ; 
         X 2  to X 5  are each, independently, N, CH, CR 1 , or C—, wherein —C represents the point of attachment of group B, and wherein at most one of X 2  to X 5  is N, and one of X 2  to X 5  is —C. 
         X 7  to X 10  are each, independently, N, CH, or CR 2 , wherein at most one of X 7  to X 10  is N; 
         X 11  to X 14  are each, independently N, CH, CR 3 , or C—, wherein —C represents the point of attachment of group B, and wherein at most one of X 11  to X 14  is N, and one of X 11  to X 14  is —C; 
         X 15  to X 17  are each, independently N, O, S, CH, or CR 4 ; 
         X 13  to X 21  are each, independently N, CH, or CR 5 , wherein at most one of X 18  to X 21  is N; 
         X 22  and X 23  are each, independently, CH or CR 12 , wherein at least one of X 22  or X 23  is CR 12 ; 
         X 24  is either CH or N; 
         B is CH 2 , C═O, or C═S; 
         B 1  is CH; 
         Y is O or S; 
         Z is O or NR 11 ; 
         m is 1 or 2; 
         R is H, alkyl having 1 to 4 carbon atoms, halogenated alkyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, cycloalkylalkyl having 4 to 7 carbon atoms, or C 1-6 alkyl-Ar, 
         R 1 R 2 R 4  and R 5  are each, independently,
 C 1-6 -alkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 NR 6 R 7 , SH, SR 6 SOR 6 C 3-8 -cycloalkyl, SO 2 R 1 SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkenyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 NR 6 R 7 , SH, SR 6 SOR 7 C 3-8 cycloalkyl, SO 2 R 6 SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkynyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 7 , C 3-8 cycloalkyl, SO 2 R 6 SO 2 NR 6 R 7 , Si(R 8 ) 3 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 NR 6 R 7 , SH, SR 6 SOR 6  unsubstituted C 3-8 cycloalkyl, SO 2 R 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 4-10 -cycloalkylalkyl which is unsubstituted or substituted in the cycloalkyl portion one or more times by F, Cl, Br, I, CN, OR 16 NR 6 R 7 , SH, SR 6 SOR 6 , unsubstituted C 3-8 : cycloalkyl, SO 2 R 1 SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, and/or substituted in the alkyl portion one or more times by one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof 
 halogen, 
 CN, NO 2 , NR 6 R 7 , SR 6 SOR 6 SO 2 R 6  SO 2 NR 6 R 7 , NR 6 SO 2 R 7 CONR 6 R 7 , CSNR 6 R 7 COOR 6 , NR 6 COR 7 NR 6 CSR 7 NR 6 CONR 6 R 7 NR 6 CSNR 6 R 7 NR 6 COOR 7 NR 6 CSOR 7 , OCONR 6 R 7 , OCSNR 6 R 7 , 
 Ar, 
 Het, or 
 
         R 3  is halogen, OR 16 , CN, nitro, alkyl having 1 to 4 carbon atoms, halogenated alkyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, cycloalkylalkyl having 4 to 7 carbon atoms, hydroxyalkyl h having 1 to 4 carbon atoms, NH—, monoalkylamino having 1 to 4 carbon atoms, dialkylamino wherein each alkyl group independently has 1 to 4 carbon atoms, Ar or Het; 
         R 6  and R 7  are each independently
 H, 
 C 1-6 -alkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, 
 C 3-6 -alkenyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, 
 C 3-6 -alkynyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Si(R 8 ) 3 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, 
 C 4-10 -cycloalkylalkyl which is unsubstituted or substituted in the cycloalkyl portion one or more times by F, Cl, Br, I, CN, OR 16 , monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, and/or substituted in the alkyl portion one or more times by one or more times by F, Cl, Br, I, CN, OR 16 , monoalkylamino having 1 to 6 carbon atoms, dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, C 3-8 -cycloalkyl, Ar, Het, or combinations thereof, 
 Ar, or 
 Het; 
 
         R 8  is C 1-6 -alkyl; 
         R 9  is H,
 C 1-6 -alkyl which is unsubstituted or substituted one or more by F, Cl, Br, I, CN, OR 16 NR 6 R 7 , SH, SR 6 SOR 6 C 3-8 -cycloalkyl, SO 2 R 6 SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkenyl which is unsubstituted or substituted one or more by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 SOR 6 C 3-8 -cycloalkyl, SO 2 R 6 SO 2 NR 6 R 7 , Ar, Het, or combinations thereof 
 C 3-6 -alkynyl which is unsubstituted or substituted one or more by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 SOR 6 C 3-8 -cycloalkyl, SO 2 R 6 SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 NR 6 R 7 , SH, SR 6 SOR 6 , unsubstituted C 3-8 cycloalkyl, SO 1 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 4-8 -cycloalkylalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 cycloalkyl, SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 Ar, or 
 Het; 
 
       
       R 10  is H, alkyl having 1 to 4 carbon atoms, halogenated alkyl having 1 to 4 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, or cycloalkylalkyl having 4 to 7 carbon atoms;
 R 11  is H, alkyl having 1 to 4 carbon atoms which is unsubstituted or substituted one or more times by halogen, OR 16 , C 3-8 cycloalkyl NR 6 R 7 , Ar, or Het, cycloalkyl having 3 to 7 carbon atoms which is unsubstituted or substituted one or more times by halogen, OR 16 , NR 6 R 7 , Ar, or Het, cycloalkylalkyl having 4 to 7 carbon atoms, Ar or Het; 
 R 12  is C 1-6 -alkoxy which is substituted one or more times by F, or is selected from Formulae IX-XI 
 
       
         
           
           
               
               
           
         
       
       wherein Formula IX represents a 5-membered, unsaturated heterocycle Formula X represents a 5-8-membered, heterocycle which is saturated or partially saturated and wherein the heterocyclic ring may be bridged by a divalent alkylene group having 1 to 3 carbon atoms, and Formula XI represents a 5-8-membered, heterocycle which is saturated, partially saturated, or unsaturated and wherein the heterocyclic ring may be bridged by a divalent alkylene group having 1 to 3 carbon atoms;
 is O, S, N, NR 3 , or SO 2 ; 
 is CH, CR 14 , CHR 14 , O, S, SO 2 , N, or NR 13 . 
 T is O or NR 10 ; 
 V 1  is O, S, SO 2 , N, NR 13 , CR 13 , or CHR 14 ; 
 W 1  is N; 
 W 2  and W 3  are each, independently, O, S, N, NR 13 , CH, or CR 1 , in which the bond between W 2  and W 3  is a single bond and the bond between W 3  and W 4  is a double bond, or the bond between W 2  and W 3  is a double bond and the bond between W 3  and W 4  is a single bond; 
 W 4  is O, S, N, or NR 13 ; 
 V 2  is C, CH, C—OH, or N; 
 R 13  is H,
 C 1-6 -alkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 SOR 6 C 3-8 cycloalkyl, SO 2 R 7 SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-6 -alkenyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 SOR 6 C 3-8 cycloalkyl, SO 2 R 7 SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-6 -alkynyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 SOR 6 C 3-8 cycloalkyl, SO 2 R 7 SO 2 NR 6 R 7 , Si(R 8 ) 3 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 4-10 -cycloalkylalkyl which is unsubstituted or substituted in the cycloalkyl portion one or more times by F, Cl, Br, I, CN, OR 16 NR 16 R 6 , SH, SR 7 SOR 6  unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, and/or substituted in the alkyl portion one or more times by one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 SO 2 R 6 , CONR 6 R 7 , CSNR 6 R 7 , COOR 6 , CSOR 6 , COR 7 , CSR 7 , 
 Ar, or 
 Het; 
 
 R 14  is H,
 C —-6 -alkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 9 , NR 7 R 6 , SH, SR 6 , SOR 6 C 3-8 -cycloalkyl, SO 2 R 7 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkenyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 9 , NR 7 R 6 , SH, SR 6 , SOR 6 C 3-8 -cycloalkyl, SO 2 R 1 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkynyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 9 , NR 7 R 6 , SH, SR 6 , SOR 6 C 3-8 -cycloalkyl, SO 2 R 6 SO 2 NR 6 R 6 , Si(R 8 ) 3 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 9 , NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 , R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 4-10 -cycloalkylalkyl which is unsubstituted or substituted in the cycloalkyl portion one or more times by F, Cl, Br, I, CN, OR 9 , NR 6 R 7 , SH, SR 6 , SOR 6  unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, and/or substituted in the alkyl portion one or more times by one or more times by F, Cl, Br, I, CN, OR 16 NR 6 R 7 , SH, SR 6 SOR 6 , C 3-8 -cycloalkyl SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 halogen, 
 CN, NO 2 , NR 6 R 7 SR 6 SOR 6 SO 2 R 6 SO 2 NR 6 R 7 , NR 6 SO 2 R 7 , CONR 6 R 7 , CSNR 6 R 7 , COOR 6 NR 6 COR 7 NR 6 CSR 7 NR 6 CONR 6 R 7 NR 6 CSNR 6 R 7 NR 6 COOR 7 NR 6 CSOR 7 , OCONR 6 R 7 , OCSNR 6 R 7 , 
 Ar, 
 Het, or 
 
 R 15  is H,
 C 1-6 -alkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 6 NR 7 R 6 , SH, SR 6 SOR 6 C 3-8 cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkenyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 6 , NR 7 R 6 , SH, SR 6 , SOR 6 , C 3-8 cycloalkyl, SO 2 R 7 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 2-6 -alkynyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 , NR 7 R 6 , SH, SR 6 , SOR 6 , C 3-8 cycloalkyl, SO 2 R 6 , SO 2 NR 16 R 7 , Si(R 8 ) 3 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 NR 6 R 7 , SH, SR 6 SOR 6  unsubstituted C 3-8 cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 4-10 -cycloalkylalkyl which is unsubstituted or substituted in the cycloalkyl portion one or more times by F, CL, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, and/or substituted in the alkyl portion one or more times by one or more times by F, Cl, Br, I, CN, OR 16 , NR 6 R 7 , SH, SR 6 SOR 6 C 3-8 -cycloalkyl, SO 2 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyloxy which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OR 16 NR 6 R 7 , SH, SR 6 SOR 6  unsubstituted C 3-8 cycloalkyl, SO 2 , R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 halogen, 
 oxo, thio, CN, NO, NR 6 R 7 SR 6 SOR 6 SOR 6 S0-NR 6 R 7 NR 6 SO 2 R 7 CONR 6 R 7 CSNR 6 R 7 COOR 6 NR 6 COR 7 , NR 6 CSR 7 , NR 6 CONR 6 R 7 , NR 6 CSNR 6 R 7 , NR 6 COOR 7 , NR 6 CSOR 7 , OCONR 6 R 7 , OCSNR 6 R 7 , 
 Ar, 
 Het, or 
 
 R 16  is H,
 C 1-6 -alkyl which is unsubstituted or substituted one or more by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 6 , C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, 
 C 3-8 -cycloalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof, or 
 C 4-8 -cycloalkylalkyl which is unsubstituted or substituted one or more times by F, Cl, Br, I, CN, OH, alkoxy having 1 to 4 carbon atoms, NR 6 R 7 , SH, SR 6 , SOR 6 , unsubstituted C 3-8 -cycloalkyl, SO 2 R 6 , SO 2 NR 6 R 7 , Ar, Het, or combinations thereof; 
 
 Ar is an aryl group containing 6 to 10 carbon atoms which is unsubstituted or substituted one or more times by
 alkyl having 1 to 8 carbon atoms, 
 alkoxy having 1 to 8 carbon atoms, 
 halogen, 
 
 amino
 cyano, 
 hydroxyl, 
 nitro, 
 halogenated alkyl having 1 to 8 carbon atoms, 
 halogenated alkoxy having 1 to 8 carbon atoms, 
 hydroxyalkyl having 1 to 8 carbon atoms, 
 hydroxyalkoxy having 2 to 8 carbon atoms, 
 alkenyloxy having 3 to 8 carbon atoms, 
 monoalkylamino having 1 to 8 carbon atoms, 
 dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, 
 carboxy, 
 alkoxycarbonyl 
 alkylaminocarbonyl, 
 acylamido, 
 acyloxy, 
 alkylthio having 1 to 8 carbon atoms, 
 alkylsulphinyl having 1 to 8 carbon atoms, 
 alkylsulphonyl having 1 to 8 carbon atoms, 
 sulfo 
 sulfonylamino, 
 Het, 
 cycloalkylamino wherein the cycloalkyl group has 3 to 7 C atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 aryloxy wherein the aryl portion contains 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 arylthio wherein the aryl portion contains 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 cycloalkyloxy wherein the cycloalkyl group has 3 to 7 C atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, or combinations thereof; and 
 
 Het is a heterocyclic group, which is fully saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is a N, O or S atom, which is unsubstituted or substituted one or more times by
 alkyl having 1 to 8 carbon atoms, 
 alkoxy having 1 to 8 carbon atoms, 
 halogen, 
 amino 
 cyano, 
 hydroxyl, 
 nitro, 
 halogenated alkyl having 1 to 8 carbon atoms, 
 halogenated alkoxy having 1 to 8 carbon atoms, 
 hydroxyalkyl having 1 to 8 carbon atoms, 
 hydroxyalkoxy having 2 to 8 carbon atoms, 
 alkenyloxy having 3 to 8 carbon atoms, 
 monoalkylamino having 1 to 8 carbon atoms, 
 dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, 
 carboxy, 
 alkoxycarbonyl 
 alkylaminocarbonyl, 
 acylamido, 
 acyloxy, 
 alkylthio having 1 to 8 carbon atoms, 
 alkylsulphinyl having 1 to 8 carbon atoms, 
 alkylsulphonyl having 1 to 8 carbon atoms, 
 oxo, 
 sulfonylamino, 
 cycloalkylamino wherein the cycloalkyl group has 3 to 7 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 aryl containing 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 aryl-alkylene group wherein the aryl portion contains 6 to 10 carbon atoms and the alkylene portion contains 1 to 4 carbon atoms and is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 8 C atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 aryloxy wherein the aryl portion contains 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 arylthio wherein the aryl portion contains 6 to 10 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 cycloalkyloxy wherein the cycloalkyl group has 3 to 7 carbon atoms and is optionally substituted by halogen, alkyl having 1 to 8 C carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, 
 heterocyclic group, which is fully saturated, partially saturated or fully unsaturated, having 5 to 10 ring atoms in which at least 1 ring atom is a N, O or S atom, which is unsubstituted or substituted one or more times by halogen, alkyl having 1 to 8 carbon atoms, halogenated alkyl having 1 to 8 carbon atoms, alkoxy having 1 to 4 carbon atoms, amino, monoalkylamino wherein the alkyl portion has 1 to 8 carbon atoms, dialkylamino wherein the alkyl portions each have 1 to 8 carbon atoms, COR 9 , CSR 9 , cyano, hydroxyl, nitro, oxo, or thio, or combinations thereof; and 
 
 
       pharmaceutically acceptable salts thereof;
 wherein when said compound is of Formulas I, II, V, VI, VII or VII, VIII is 1. 
 
     
     
         43 . (canceled) 
     
     
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         53 . (canceled) 
     
     
         54 . (canceled) 
     
     
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         56 . (canceled) 
     
     
         57 . (canceled) 
     
     
         58 . (canceled) 
     
     
         59 . (canceled) 
     
     
         60 . (canceled) 
     
     
         61 . (canceled) 
     
     
         62 . (canceled) 
     
     
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         66 . (canceled) 
     
     
         67 . (canceled) 
     
     
         68 . A compound according to  claim 38 , wherein said compound is a hydrochloride salt or a hydroformate salt. 
     
     
         69 . A compound according to  claim 68 , wherein said compound is selected from: 
       3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-1,2-benzisothiazole hydroformate, and 
       3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-6-methoxy-1,2-benzisothiazole hydroformate. 
     
     
         70 . A compound according to  claim 40 , wherein said compound is a hydrochloride salt or a hydroformate salt. 
     
     
         71 . A compound according to  claim 70 , wherein said compound is selected from: 
       3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-1,2-benzisoxazole hydroformate, 
       3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-6-(ethoxy)-1,2-benzisothiazole hydroformate, 
       3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-6-(trifluoromethoxy)-1,2-benzisothiazole hydroformate, 
       3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-7-(methoxy)-1,2-benzisothiazole hydroformate, and 
       6-Cyclopropyl-3-(1,4-diazabicyclo[3.2.2]non-4-ylcarbonyl)-1,2-benzisothiazole hydroformate. 
     
     
         72 . A compound according to  claim 41 , wherein said compound is a hydrochloride salt or a hydroformate salt. 
     
     
         73 . A compound according to  claim 72 , wherein said compound is selected from: 
       3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-1,2-benzisothiazol-6-ol hydroformate, 
       3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-6-(methoxy)-1,2-benzisothiazole hydroformate, 
       6-Bromo-3-(1,4-diazabicyclo[3.2.2]non-4-ylcarbonyl)-1,2-benzisothiazole hydroformate, 
       1-[3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-1,2-benzisothiazol-6-yl]-3-isopropylimidazolidin-2-one hydroformate, and 
       1-[3-(1,4-Diazabicyclo[3.2.2]non-4-ylcarbonyl)-1,2-benzisothiazol-6-yl]-3-methylimidazolidin-2-one hydroformate.
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