4-phenylpiperidine compounds

Abstract

The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I: wherein: R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl group optionally substituted by C 1-4 alkyl, alkylthio, alkoxy, halogen, nitro, acylamino, methylsulfonyl or methylenedioxy, or represents tetrahydronaphthyl, R 1 represents hydrogen, trifluoro (C 1-4 ) alkyl, alkyl or alkynyl, X represents hydrogen, alkyl having 1-4 carbon atoms, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio or aralkoxy, R 2 represents: a C1-C10 alkyl group, a phenyl group optionally substituted by one or more of the following groups: a C1-C10 alkyl group, a halogen group, a nitro group, hydroxy group, and/or an alkoxy group.

1 . A compound, and pharmaceutically acceptable salts, having the formula I: 
     
       
         
         
             
             
         
       
     
     wherein:
 R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl group optionally substituted by C 1-4  alkyl, alkylthio, alkoxy, halogen, nitro, acylamino, methylsulfonyl or methylenedioxy, or -represents tetrahydronaphthyl, 
 R 1  represents hydrogen, trifluoro (C 1-4 ) alkyl, alkyl or alkynyl, 
 X represents hydrogen, alkyl having 1-4 carbon atoms, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio or aralkoxy, 
 R 2  represents:
 a C 1 -C 10  alkyl group, 
 a phenyl group optionally substituted by one or more of the following groups: 
 a C 1 -C 10  alkyl group, 
 a halogen group, 
 a nitro group, 
 hydroxy group, 
 and/or an alkoxy group. 
 
 
   
   
       2 .- 23 . (canceled)