Analgesic agent comprising cyclic phosphatidic acid derivative

Abstract

An object of the present invention is to elucidate an analgesic effect as one of new cPA bioactivities and thus to provide a novel analgesic agent. The present invention provides an analgesic agent which comprises a cyclic phosphatidic acid derivative that is one type of phospholipid.

1 . An analgesic agent, which comprises a compound represented by the formula (1) as an active ingredient: 
     
       
         
         
             
             
         
       
       wherein R represents C1-30 linear or branched alkyl, C2-30 linear or branched alkenyl, or C2-30 linear or branched alkynyl, provided that such groups may optionally contain a cycloalkane ring or an aromatic ring; X and Y each independently represents —O— or —CH 2 —, provided that X and Y do not simultaneously represent —CH 2 —; and M represents a hydrogen atom or a counter cation. 
     
   
   
       2 . The analgesic agent according to  claim 1 , wherein in the formula (1), X and Y represent —O—. 
   
   
       3 . The analgesic agent according to  claim 1 , wherein in the formula (1), X or Y represents —CH 2 —. 
   
   
       4 . The analgesic agent according to  claim 1 , wherein the compound represented by the formula (1) is 1-oleoyl cyclic phosphatidic acid or 1-palmitoleoyl cyclic phosphatidic acid. 
   
   
       5 . The analgesic agent according to  claim 2 , wherein the compound represented by the formula (1) is 1-oleoyl cyclic phosphatidic acid or 1-palmitoleoyl cyclic phosphatidic acid. 
   
   
       6 . The analgesic agent according to  claim 3 , wherein the compound represented by the formula (1) is 1-oleoyl cyclic phosphatidic acid or 1-palmitoleoyl cyclic phosphatidic acid.