Bone filler for cartilage tissue regeneration treatment

Abstract

It is intended to provide a medical material which enables a new method for cartilage tissue regeneration treatment based on an entirely new concept unlike a treatment method by transplantation of autologous cartilage tissue, a cartilage alternative or undifferentiated cells. The invention provides a bone filler for cartilage tissue regeneration comprising hydrogel having an interpenetrating network structure formed by two or more crosslinked network polymers or a semi-interpenetrating network structure formed by a crosslinked network polymer and a linear polymer. By filling the bone filler of the invention in a hole or a groove provided in subchondral bone just under damaged cartilage tissue, regeneration of the cartilage tissue or both the cartilage tissue and the subchondral bone can be promoted.

1 : A bone-filling cartilage tissue regeneration inducer, comprising hydrogel having an interpenetrating network structure formed by two or more polymers having a crosslinked network structure or a semi-interpenetrating network structure formed by a polymer having a crosslinked network structure and a linear polymer. 
   
   
       2 : The bone-filling cartilage tissue regeneration inducer as set forth in  claim 1 , wherein a polymer having a crosslinked network structure or a linear polymer is a polymer consisting of a charged unsaturated monomer and/or an electrically neutral unsaturated monomer. 
   
   
       3 : The bone-filling cartilage tissue regeneration inducer as set forth in  claim 2 , wherein a charged unsaturated monomer is an unsaturated monomer having acidic group and/or basic group. 
   
   
       4 : The bone-filling cartilage tissue regeneration inducer as set forth in  claim 3 , wherein acidic group is carboxyl group, phosphate group, sulfonic acid group or salt consisting thereof. 
   
   
       5 : The bone-filling cartilage tissue regeneration inducer as set forth in  claim 3 , wherein an unsaturated monomer having acidic group is 2-acrylamide-2-methylpropanesulfonic acid or salt consisting thereof. 
   
   
       6 : The bone-filling cartilage tissue regeneration inducer as set forth in  claim 2 , wherein an electrically neutral unsaturated monomer is N,N-dimethyl-acrylamide. 
   
   
       7 : The bone-filling cartilage tissue regeneration inducer as set forth in  claim 1 , comprising hydrogel having an interpenetrating network structure comprising a polymer having a crosslinked network structure with 2-acrylamide-2-methylpropanesulfonic acid as a monomer and a polymer having a crosslinked network structure with N,N-dimethyl-acrylamide as a raw monomer. 
   
   
       8 : A bone-filling cartilage or cartilage tissue regeneration inducer, comprising hydrogel having an interpenetrating network structure formed by two or more polymers having a crosslinked network structure or a semi-interpenetrating network structure formed by a polymer having a crosslinked network structure and a linear polymer. 
   
   
       9 : The bone-filling cartilage or cartilage tissue regeneration inducer as set forth in  claim 8 , comprising hydrogel having an interpenetrating network structure comprising a polymer having a crosslinked network structure with 2-acrylamide-2-methylpropanesulfonic acid as a monomer and a polymer having a crosslinked network structure with N,N-dimethyl-acrylamide, acrylamide or 2-acrylamide-2-methylpropane sodium sulphate as a raw monomer.