Reaction and separation methods

Abstract

A method of separating compounds that includes the steps of: tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; tagging at least a second organic compound with a second tagging moiety different from the first tagging moiety to result in a second tagged compound; and separating the first tagged compound from a mixture including the second tagged compound using a separation technique based upon differences between the first tagging moiety and the second tagging moiety. Preferably, the separation technique is based upon difference in the fluorous nature of the first tagged compound and the second tagged compound, differences in total charge between the first tagged compound and the second tagged compound, differences in size between the first tagged compound and the second tagged compound, and/or differences in polarity between the first tagged compound and the second tagged compound. The present invention also provides a method for carrying out a chemical reaction including the steps of: tagging a plurality of compounds with different tagging moieties to create tagged compounds, conducting at least one chemical reaction on a mixture of the tagged compounds to produce a mixture of tagged products, and separating the mixture of tagged products by a separation technique based upon differences in the tagging moieties.

1 . A method for carrying out a liquid phase chemical reaction, comprising: tagging a plurality of compounds with different tagging moieties to create tagged compounds, conducting at least one chemical reaction on the tagged compounds to produce a mixture of tagged products in a liquid phase, and physically separating at least one of the tagged products from the mixture of tagged products by a method based upon differences in the tagging moieties. 
   
   
       2 . The method of  claim 2  further including the step of removing the tagging moieties from the tagged products. 
   
   
       3 . The method of  claim 2  wherein the tagging moieties are fluorous moieties that differ in fluorous nature. 
   
   
       4 . The method of  claim 3  wherein the fluorous tagging moieties differ in fluorine content or structure. 
   
   
       5 . The method of  claim 3  wherein the tagged products are separated by using fluorous reverse phase chromatography. 
   
   
       6 . The method of  claim 1  wherein a first plurality of compounds is tagged with a first tagging moiety and mixed with other tagged compounds that are tagged with tagging moieties different from the first tagging moiety. 
   
   
       7 . The method of  claim 6  wherein the separation of the tagged products provides mixtures of product compounds bearing the same initial tag. 
   
   
       8 . The method of  claim 1  wherein the tagged compounds are reacted with a mixture of different starting compounds. 
   
   
       9 . The method of  claim 1  wherein the tagged compounds are selectively tagged with different tagging moieties such that the tagged products separate into fractions of known identity as determined by the tagging moieties. 
   
   
       10 . A method for carrying out a liquid phase chemical reaction, comprising: tagging a plurality of compounds with different fluorous tagging moieties to create tagged compounds, conducting at least one chemical reaction on the tagged compounds to produce a mixture of tagged products in a liquid phase, and physically separating at least one of the tagged products from the mixture of tagged products by a method based upon differences in the fluorous nature of the tagging moieties. 
   
   
       11 . The method of  claim 10  further including the step of removing the fluorous tagging moieties from the tagged products. 
   
   
       12 . The method of  claim 10  wherein the fluorous tagging moieties differ in fluorine content or structure. 
   
   
       13 . The method of  claim 12  wherein the tagged products are separated using fluorous reverse phase chromatography. 
   
   
       14 . The method of  claim 10  wherein a first plurality of compounds is tagged with a first tagging moiety and mixed with other tagged compounds that are tagged with tagging moieties different from the first tagging moiety. 
   
   
       15 . The method of  claim 10  wherein the separation of the tagged products provides mixtures of product compounds bearing the same initial tag. 
   
   
       16 . The method of  claim 10  wherein the tagged compounds are reacted with a mixture of different starting compounds. 
   
   
       17 . The method of  claim 10  wherein a first plurality of compounds is tagged with a first fluorous tagging moiety and mixed with other tagged compounds that are tagged with fluorous tagging moieties different from the first tagging moiety. 
   
   
       18 . The method of  claim 17  wherein the separation of the tagged products provides mixtures of product compounds bearing the same initial tag. 
   
   
       19 . The method of  claim 18  wherein the tagged compounds are reacted with a mixture of different starting compounds. 
   
   
       20 . The method of  claim 10  wherein the tagged compounds are selectively tagged with different tagging moieties such that the tagged products separate into fractions of known identity as determined by the tagging moieties.