Dermatological/cosmetic compositions comprising a retinoid and benzoyl peroxide

Abstract

Dermatological/cosmetic compositions contain, in a physiologically acceptable medium, at least one retinoid, dispersed benzoyl peroxide and a gelling system comprising at least two categories of compounds.

1 . A dermatological/cosmetic composition comprising:
 at least one retinoid;   benzoyl peroxide; and   a gelling system which comprises at least two categories of compounds,   
     said categories of compounds being selected from among silicates, cellulose gelling agents and polysaccharide gums, with the proviso that when at least two gelling agents are selected from among aluminum/magnesium silicate, xanthan gum and hydroxypropyl cellulose, the gelling system is composed of these two gelling agents, or comprises at least one gelling agent different from these three compounds. 
   
   
       2 . The dermatological/cosmetic composition as defined by  claim 1 , comprising magnesium and aluminum silicates. 
   
   
       3 . The dermatological/cosmetic composition as defined by  claim 1 , comprising an amount of silicate ranging from 0.1 to 10% by weight relative to the total weight of the composition. 
   
   
       4 . The dermatological/cosmetic composition as defined by  claim 1 , comprising cellulose gelling agents selected from among methyl cellulose, ethyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, hydroxymethyl cellulose and hydroxypropyl cellulose. 
   
   
       5 . The dermatological/cosmetic composition as defined by  claim 1 , comprising an amount of cellulose gelling agent ranging from 0.1 to 10% by weight relative to the total weight of the composition. 
   
   
       6 . The dermatological/cosmetic composition as defined by  claim 1 , comprising an amount of polysaccharide gum ranging from 0.01 to 5% by weight relative to the total weight of the composition. 
   
   
       7 . The dermatological/cosmetic composition as defined by  claim 1 , wherein the gelling system comprises at least one cellulose gelling agent in combination with a silicate. 
   
   
       8 . The dermatological/cosmetic composition as defined by  claim 1 , wherein the gelling system comprises at least one silicate in combination with a polysaccharide gum. 
   
   
       9 . The dermatological/cosmetic composition as defined by  claim 1 , wherein the gelling system comprises at least one polysaccharide gum in combination with a cellulose gelling agent. 
   
   
       10 . The dermatological/cosmetic composition as defined by  claim 1 , wherein the gelling system comprises at least one silicate, at least one cellulose gelling agent and at least one polysaccharide gum. 
   
   
       11 . The dermatological/cosmetic composition as defined by  claim 1 , comprising from 0.0001 to 20% of retinoid. 
   
   
       12 . The dermatological/cosmetic composition as defined by  claim 1 , wherein the retinoid comprises adapalene. 
   
   
       13 . The dermatological/cosmetic composition as defined by  claim 1 , comprising from 0.0001 to 20% of benzoyl peroxide. 
   
   
       14 . The dermatological/cosmetic composition as defined by  claim 1 , wherein the benzoyl peroxide is encapsulated or free. 
   
   
       15 . The dermatological/cosmetic composition as defined by  claim 1 , comprising a propenetrating agent. 
   
   
       16 . The dermatological/cosmetic composition as defined by  claim 15 , said propenetrating agent comprising propylene glycol. 
   
   
       17 . The dermatological/cosmetic composition as defined by  claim 1 , comprising a wetting liquid surfactant. 
   
   
       18 . The dermatological/cosmetic composition as defined by  claim 17 , said wetting liquid surfactant comprising a poloxamer. 
   
   
       19 . The dermatological/cosmetic composition as defined by  claim 1 , which comprises, in water:
 2.5% of benzoyl peroxide;   0.1% of adapalene;   0.1% of disodium EDTA;   2%-4% of glycerol;   2%-6% of propylene glycol;   0%-0.05% of sodium docusate;   2%-4% of a gelling system; and   0.2%-0.5% of Poloxamer 124.   
   
   
       20 . The dermatological/cosmetic composition as defined by  claim 1 , which comprises, in water: 
     
       
         
               
               
               
             
                   
                   
               
                   
                 Adapalene 
                 0.1% 
               
                   
                 Benzoyl peroxide 
                 qs 2.5% BPO 
               
                   
                 Propylene glycol 
                   4% 
               
                   
                 Poloxamer 124 
                 0.1% 
               
                   
                 Aluminum/magnesium silicate 
                   2% 
               
                   
                 Hydroxyethyl cellulose 
                 1.5% 
               
                   
                 Xanthan gum 
                 0.5% 
               
                   
                 Glycerol 
                   2% 
               
                   
                 Sodium docusate 
                 0.05%  
               
                   
                   
               
           
              
             
             
              
              
              
              
              
              
              
              
              
              
             
          
         
       
     
   
   
       21 . A medication comprising the dermatological/cosmetic composition as defined by  claim 1 . 
   
   
       22 . A regime or regimen to prevent and/or treat a dermatological condition linked to cell differentiation and/or proliferation disorders and/or keratinization disorders, comprising administering to an individual in need of such treatment, a thus effective amount of the dermatological/cosmetic composition as defined by  claim 1 . 
   
   
       23 . A regime or regimen to prevent and/or treat acne vulgaris, comprising administering to an individual in need of such treatment, a thus effective amount of the dermatological/cosmetic composition as defined by  claim 1 . 
   
   
       24 . A regime or regimen for treating acne-prone skin, for hair regrowth, for preventing hair loss, for combating the greasy appearance of the skin or hair, for protecting against the damaging effects of the sun or for treating physiologically greasy skin, or for preventing and/or combating light-induced or chronological aging, comprising administering to an individual in need of such treatment, a thus effective amount of the dermatological/cosmetic composition as defined by  claim 1 .