Prophylactic agent for heart failure

Abstract

The present invention provides an agent having a suppressive action against the thickening of the heart wall, a prophylactic agent for heart failure containing the above described agent, and functional foods expected to have a prophylactic effect for heart failure. The agent for suppressing heart wall thickening comprises Xaa Pro Pro as an active ingredient.

1 . An agent for suppressing heart wall thickening, comprising Xaa Pro Pro as an active ingredient. 
     
     
         2 . The agent for suppressing heart wall thickening according to  claim 1 , wherein said Xaa Pro Pro is Val Pro Pro and/or Ile Pro Pro. 
     
     
         3 . The agent for suppressing heart wall thickening according to  claim 1 , wherein said Xaa Pro Pro is derived from an animal milk casein hydrolysate or a concentrate thereof. 
     
     
         4 . The agent for suppressing heart wall thickening according to  claim 3 , wherein said animal milk casein hydrolysate is a fermented product obtained by fermenting said animal milk casein with  Aspergillus.    
     
     
         5 . The agent for suppressing heart wall thickening according to  claim 3  wherein said animal milk casein hydrolysate is a hydrolyzed product obtained by degrading said animal milk casein with an enzyme derived from  Aspergillus.    
     
     
         6 . The agent for suppressing heart wall thickening according to  claim 5 , wherein said enzyme derived from said  Aspergillus  is an enzyme derived from  Aspergillus oryzae.    
     
     
         7 . The agent for suppressing heart wall thickening according to  claim 1 , wherein said Xaa Pro Pro is a fermented product obtained by fermenting a raw material containing a milk protein with a bacterium belonging to the species  Lactobacillus helveticus.    
     
     
         8 . The agent for suppressing heart wall thickening according to  claim 7 , wherein said bacterium belonging to the species  Lactobacillus helveticus  is  Lactobacillus helveticus  CM4 strain (FERM BP-6060). 
     
     
         9 . A prophylactic agent for cardiac hypertrophy comprising said agent for suppressing heart wall thickening according to  claim 1  as an active ingredient. 
     
     
         10 . A prophylactic agent for heart failure comprising said agent for suppressing heart wall thickening according to  claim 1  as an active ingredient. 
     
     
         11 . A functional food comprising said agent for suppressing heart wall thickening according to  claim 1 . 
     
     
         12 . The functional food according to  claim 11 , which indicates efficacy for prophylaxis of heart failure. 
     
     
         13 . The agent for suppressing heart wall thickening according to  claim 2 , wherein said Xaa Pro Pro is derived from an animal milk casein hydrolysate or a concentrate thereof. 
     
     
         14 . The agent for suppressing heart wall thickening according to  claim 2 , wherein said Xaa Pro Pro is a fermented product obtained by fermenting a raw material containing a milk protein with a bacterium belonging to the species  Lactobacillus helveticus.    
     
     
         15 . A prophylactic agent for cardiac hypertrophy comprising said agent for suppressing heart wall thickening according to  claim 2  as an active ingredient. 
     
     
         16 . A prophylactic agent for cardiac hypertrophy comprising said agent for suppressing heart wall thickening according to  claim 3  as an active ingredient. 
     
     
         17 . A prophylactic agent for cardiac hypertrophy comprising said agent for suppressing heart wall thickening according to  claim 4  as an active ingredient. 
     
     
         18 . A prophylactic agent for cardiac hypertrophy comprising said agent for suppressing heart wall thickening according to  claim 5  as an active ingredient. 
     
     
         19 . A prophylactic agent for cardiac hypertrophy comprising said agent for suppressing heart wall thickening according to  claim 6  as an active ingredient. 
     
     
         20 . A prophylactic agent for cardiac hypertrophy comprising said agent for suppressing heart wall thickening according to  claim 7  as an active ingredient.