Method of treating dermatitis comprising administering a chymase inhibitor

Abstract

A medicament safe and free from side effects, for the prevention or treatment of dermatitis exhibiting a biphasic inflammation reaction or dermatitis induced by repeated exposure to an antigen, which suppresses the progress of the condition and improves the quality of life of the patient, which medicament treats dermatitis exhibiting a biphasic inflammation reaction or dermatitis induced by repeated exposure to an antigen by including a quiazoline derivative having the formula (I) or (II) or its pharmaceutically acceptable salt as an effective ingredient:

1 - 16 . (canceled) 
     
     
         17 . A method for prevention or treatment of dermatitis exhibiting a biphasic skin reaction comprising administering to a patient in need of such treatment a chymase inhibitor in an amount effective for alleviating late-phase reaction. 
     
     
         18 . A method according to  claim 17 , wherein the dermatitis exhibiting a biphasic skin reaction is atopic dermatitis. 
     
     
         19 . A method for alleviation of late-phase reaction of dermatitis exhibiting biphasic skin reaction comprising administering a chymase inhibitor to a patient in need of such treatment in an amount effective for alleviating late-phase reaction of dermatitis exhibiting biphasic skin reaction. 
     
     
         20 . A method according to  claim 19 , wherein said dermatitis exhibiting a biphasic skin reaction is atopic dermatitis. 
     
     
         21 . A method for the prevention or treatment of dermatitis induced by repeated exposure to an antigen comprising administering a chymase inhibitor to a patient in need of such treatment in an amount effective for prevention or treatment of said dermatitis. 
     
     
         22 . A method according to  claim 21 , wherein said dermatitis induced by repeated exposure to an antigen is atopic dermatitis.