Antiinfective free intramammary veterinary composition

Abstract

An antiinfective-free formulation for prophylactic treatment of mastitis in dry cows comprises a seal formulation having approximately 65% by weight of bismuth sub-nitrate in a gel based on aluminum stearate. The seal formulation is prepared by adding the bismuth sub-nitrate to the gel base in at least two separate stages.

1 . A method of prophylactic treatment of mammary disorders in non-human animals during an animal's dry period by sealing the teat canal with a seal formulation to provide a physical barrier in the teat canal, wherein the seal formulation comprises bismuth subnitrate in a gel base, and wherein no antiinfective agent other than bismuth subnitrate is introduced into said teat canal during said animal's dry period. 
   
   
       2 . A prophylactic method of controlling infection of the mammary gland by a mastitis-causing organism comprising sealing the gland with a seal formulation to provide a physical barrier in the teat canal, wherein the seal formulation comprises bismuth subnitrate in a gel base and wherein no antiinfective agent other than bismuth subnitrate is introduced into said teat canal during said animal's dry period. 
   
   
       3 . A method as claimed in  claim 1  wherein the seal formulation contains at least 40% by weight of bismuth subnitrate. 
   
   
       4 . A method as claimed in  claim 2  wherein the seal formulation contains at least 40% by weight of bismuth subnitrate. 
   
   
       5 . A method as claimed in  claim 1  wherein the seal formulation contains from 50% to 75% by weight of bismuth subnitrate. 
   
   
       6 . A method as claimed in  claim 2  wherein the seal formulation contains from 50% to 75% by weight of bismuth subnitrate. 
   
   
       7 . A method as claimed in  claim 1  wherein the seal formulation contains approximately 65% by weight of bismuth subnitrate. 
   
   
       8 . A method as claimed in  claim 2  wherein the seal formulation contains approximately 65% by weight of bismuth subnitrate. 
   
   
       9 . A method as claimed in  claim 1  wherein the base is a gel based on aluminum stearate and the base includes liquid paraffin as a vehicle. 
   
   
       10 . A method as claimed in  claim 2  wherein the base is a gel based on aluminum stearate and the base includes liquid paraffin as a vehicle. 
   
   
       11 . A process for preparing a seal formulation comprising the steps of adding bismuth subnitrate, but no other antiinfective to a gel base in at least two separate stages, wherein a first portion of bismuth subnitrate is added to a gel base in a first stage and a second portion of bismuth subnitrate is added to a gel base containing the first portion of bismuth subnitrate. 
   
   
       12 . A process as claimed in  claim 11  wherein the weight ratio of the second portion of bismuth subnitrate to the first portion of bismuth subnitrate is at least 1:1 and approximately 2:1. 
   
   
       13 . A process as claimed in  claim 11  wherein the seal formulation contains at least 40% by weight of bismuth subnitrate. 
   
   
       14 . A process as claimed in  claim 11  wherein the seal formulation contains from 50% to 75% by weight of bismuth subnitrate. 
   
   
       15 . A process as claimed in  claim 11  wherein the seal formulation contains approximately 65% by weight of bismuth subnitrate. 
   
   
       16 . A process as claimed in  claim 11  wherein the base is a gel based on aluminum stearate, and the gel contains liquid paraffin as a vehicle.