Phosphohalohydrins, Process For The Production Thereof And Use Thereof

Abstract

The invention provides compounds comprising at least one phosphohalohydrin group of the formula: where X is a halogen selected from among I, Br, Cl, R1 is selected from among —CH 3 and —CH 2 —CH 3 , Cat+ is an organic or inorganic cation, and n is an integer between 2 and 20, processes for the production thereof and uses theroef, in particular therapeutic uses and for activating primate Tγ9δ2 lymphocytes.

1 . A compound selected from the group consisting of: 
     
       
         
         
             
             
         
       
     
     wherein
 X is a halogen; 
 n is 2 to 20; 
 Cat +  is a cation; 
 R1 is methyl or ethyl; and 
 
     
       
         
         
             
             
         
       
     
     where X is a halogen selected from the group consisting of I, Br and Cl,
 R1 is methyl or ethyl, 
 Cat +  is a cation, 
 n is an integer between 2 and 20, 
 R3 is:
 a halohydrin group of the formula: 
 
 
     
       
         
         
             
             
         
       
       
         an epoxide group of the formula: 
       
     
     
       
         
         
             
             
         
       
       
         an alkene group of the formula: 
       
     
     
       
         
         
             
             
         
       
       m being an integer between 1 and 20. 
     
   
   
       2 . The compound according to  claim 1 , wherein n is 2 and R1 is methyl. 
   
   
       3 . A method of treating a disease comprising administering to a patient in need of treatment a composition comprising an amount of a phosphohalohydrin compound according to  claim 1  effective to activate Tγ9δ2 lymphocytes 
   
   
       4 . The method according to  claim 3 , wherein the method further comprises administering an effective amount of IL-2 in combination with said phosphohalohydrin compound. 
   
   
       5 . A method of treating cancer in a patient comprising administering to a patient in need thereof a composition comprising an effective amount of a phosphohalohydrin compound according to  claim 1 . 
   
   
       6 . The method according to  claim 5 , wherein the method further comprises administering an effective amount of IL-2 in combination with said phosphohalohydrin compound. 
   
   
       7 . A method of treating infectious diseases in a patient comprising administering to a patient in need thereof a composition comprising an effective amount of a phosphohalohydrin compound according to  claim 1 . 
   
   
       8 . The method according to  claim 7 , wherein the method further comprises administering an effective amount of IL-2 in combination with said phosphohalohydrin compound. 
   
   
       9 . A process for the extracorporeal activation of Tγ9δ2 lymphocytes, comprising contacting Tγ9δ2 lymphocytes with a phosphohalohydrin compound of the formula: 
     
       
         
         
             
             
         
       
     
     wherein
 X is a halogen; 
 n is 2 to 20; 
 Cat +  is a cation; 
 R1 is methyl or ethyl; 
 
     in an extracorporeal medium which contains Tγ9δ2 lymphocytes, IL-2 and is compatible with T lymphocyte growth to induce the proliferation of said Tγ9δ2 lymphocytes. 
   
   
       10 . A process for inducing the extracorporeal proliferation of Tγ9δ2 lymphocytes, comprising contacting Tγ9δ2 lymphocytes with a phosphohalohydrin compound of the formula: 
     
       
         
         
             
             
         
       
     
     wherein
 X is a halogen; 
 n is 2 to 20; 
 Cat +  is a cation; 
 R1 is methyl or ethyl; 
 
     and IL-2 in an extracorporeal medium which contains Tγ9δ2 lymphocytes and is compatible with T lymphocyte growth.