US2010068785A1PendingUtilityA1

Spinosyn-producing polyketide synthases

59
Assignee: BURNS LESLEY SPriority: Feb 19, 2002Filed: Nov 11, 2009Published: Mar 18, 2010
Est. expiryFeb 19, 2022(expired)· nominal 20-yr term from priority
Inventors:Lesley S. BurnsPaul R. GraupnerPaul LewerChristine MartinWilliam A. VousdenClive WaldronBarrie Wilkinson
C12P 19/62C07H 17/08C12N 15/52A01N 43/22C07D 407/12C07H 15/26
59
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.

Claims

exact text as granted — not AI-modified
1 - 11 . (canceled) 
     
     
         12 . A hybrid spinosyn polyketide synthase that is capable of functioning in  Saccharopolyspora spinosa  to produce a biologically active 18-ethyl spinosyn compound, said hybrid polyketide synthase being the product produced by spinosyn biosynthetic DNA modified so that the DNA for the AT domain of module 2 in the spinosyn PKS is replaced with DNA for an AT domain that normally incorporates ethyl malonyl-CoA. 
     
     
         13 . (canceled) 
     
     
         14 . A hybrid spinosyn polyketide synthase of  claim 12  wherein said AT domain that normally incorporates ethyl malonyl-CoA is the AT domain of module 5 in the tylosin PKS. 
     
     
         15 . A hybrid spinosyn polyketide synthase of  claim 14  wherein said AT domain is encoded by the DNA of SEQ ID NO:26. 
     
     
         16 - 41 . (canceled)

Join the waitlist — get patent alerts

Track US2010068785A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.