Regulation of Human Transmembrane Serine Protease

Abstract

Reagents that regulate human transmembrane serine protease activity and reagents that bind to human transmembrane serine protease gene products can be used to regulate extracellular matrix degradation. Such regulation is particularly useful for treating COPD, metastasis of malignant cells, tumor angiogenesis, inflammation, atherosclerosis, neurodegenerative diseases, and pathogenic infections.

1 . A preparation of antibodies that specifically bind to a polypeptide comprising the amino acid sequence shown in SEQ ID NO:12. 
     
     
         2 . The preparation of antibodies of  claim 1  which are polyclonal. 
     
     
         3 . The preparation of antibodies of  claim 1  which are monoclonal. 
     
     
         4 . The preparation of antibodies of  claim 1  which are single-chain antibodies. 
     
     
         5 . A preparation of antibodies that specifically bind to a polypeptide comprising the amino acid sequence encoded by a cDNA insert contained within plasmid pCR11-TMSP3 (ATCC Accession No. PTA-3433). 
     
     
         6 . The preparation of antibodies of  claim 5  which are polyclonal. 
     
     
         7 . The preparation of antibodies of  claim 5  which are monoclonal. 
     
     
         8 . The preparation of antibodies of  claim 5  which are single-chain antibodies.