Microprocessor system for the analysis of physiologic and financial datasets

Abstract

A medical alarm system for processing physiologic and laboratory data in hospitals and other environments is disclosed. The alarm system provides early detection of complex pathophysiologic cascades. The alarm system detects aggregated timed patterns of inflammatory indicators, metabolic, pulse, blood pressure, oxygen saturation, and/or ventilation trends to detect expanding cascade patterns characteristic of, for example, progressive sepsis. The system may include a processor programmed to convert at least the physiologic and laboratory data of a patient into a predetermined format favorable for searching. The system may also include a processor programmed to search the formatted data to detect the progressively expanding global patterns of abnormal data characteristic of evolving sepsis and/or septic shock. The alarm system may be configured to provide an early warning for healthcare workers when a pattern indicative of progression of a complex pathophysiologic cascade is detected.

1 . A medical alarm system configured to process at least physiologic and laboratory data of at least one patient, comprising:
 a computer programmed with executable instructions to:
 identify positive and/or negative trends comprising at least a combination of inflammatory indicator trends with one or more of a metabolic trend, a pulse trend, a blood pressure trend, an oxygen saturation trend, and a ventilation trend; 
 identify a relational pattern of the positive and/or negative trends which is characteristic of one or more of sepsis, severe sepsis, septic shock, a shock cascade, and a septic shock cascade; and 
 output an alarm in response the relational pattern. 
   
     
     
         2 . The medical alarm system of  claim 1 , wherein the computer is programmed with executable instructions to:
 process timed data indicative of patient treatment;   identify an onset of the patient treatment; and   identify a timing of the patient treatment in relation to at least one component of the relational pattern.   
     
     
         3 . The medical alarm system of  claim 1 , wherein the computer is programmed with executable instructions to:
 detect at least a first trend comprising a rise in at least one inflammatory marker, and a second trend comprising at least one of a fall in bicarbonate and a rise in anion gap.   
     
     
         4 . The medical alarm system of  claim 3 , wherein the computer is programmed with executable instructions to detect at least a third trend comprising at a rise in heart rate. 
     
     
         5 . The medical alarm system of  claim 1 , wherein the computer is programmed with executable instructions to determine and output at least one indication of a type of the relational pattern. 
     
     
         6 . The medical alarm system of  claim 1 , wherein the computer is programmed with executable instructions to determine and output at least an indication of timing and types of the positive and/or negative trends along the relational pattern. 
     
     
         7 . The medical alarm system of  claim 1 , wherein the computer is programmed with executable instructions to determine and output a length of the relational pattern. 
     
     
         8 . The medical alarm system of  claim 1 , wherein the computer is programmed with executable instructions to process timed data indicative of at least one medical procedure and to determine and output at least an indication of timing of the at least one medical procedure in relation to the relational pattern. 
     
     
         9 . The medical alarm system of  claim 1 , wherein the computer is programmed with executable instructions to determine and output at least a resource utilization associated with the relational pattern. 
     
     
         10 . A medical alarm system for processing at least physiologic and laboratory data of at least one patient comprising a computer programmed with executable instructions to:
 detect trends along the data;   detect at least one progressively expanding pattern comprised of at least three trends; and   output an warning upon the detection of the at least one progressively expanding pattern.   
     
     
         11 . The medical alarm system of  claim 10 , wherein the at least one progressively expanding pattern comprises a cascade of one or more of sepsis, severe sepsis, septic shock, microcirculatory failure, and shock. 
     
     
         12 . The medical alarm system of  claim 11 , wherein the cascade is comprised of a progressively enlarging aggregation of progressively greater numbers of perturbed physiologic and laboratory data. 
     
     
         13 . A medical alarm system for processing at least physiologic and laboratory data of at least one patient comprising a computer programmed with executable instructions to:
 convert the physiologic and laboratory data into trends comprised of at least positive and negative trends of both the physiologic data and the laboratory data;   detect relational trends comprised of a combination of the positive and/or negative trends;   detect at least one progressively expanding pattern comprised of a plurality of combinations of the relational trends; and   output an alarm indicating the detection of the at least one progressively expanding pattern.   
     
     
         14 . The medical alarm system of  claim 13 , wherein the at least one progressively expanding pattern is a progressively enlarging pattern characteristic of at least one of sepsis, severe sepsis, septic shock, and microcirculatory failure, a shock cascade, and a septic shock cascade. 
     
     
         15 . The medical alarm system of  claim 13 , wherein the computer is programmed with executable instructions to determine and output at least one indication of a type of the at least one progressively expanding pattern. 
     
     
         16 . The medical alarm system of  claim 13 , wherein the computer is programmed with executable instructions to determine and output an indication of a timing and type of the relational trends along the at least one progressively expanding pattern. 
     
     
         17 . The medical alarm system of  claim 13 , wherein the computer is programmed with executable instructions to determine a length of the at least one progressively expanding pattern. 
     
     
         18 . The medical alarm system of  claim 13 , wherein the computer is programmed with executable instructions to process timed data indicative of patient treatment and to output at least an indication of timing of treatment in relation to the at least one progressively expanding pattern. 
     
     
         19 . A medical alarm system for processing at least physiologic and laboratory data of at least one patient comprising a computer programmed with executable instructions to:
 search the physiologic and laboratory data to detect timed trends comprised of at least positive and negative trends of both the physiologic data and the laboratory data;   convert the physiologic and laboratory data into a matrix of at least positive and negative trends;   determine relational timing of the detected positive and negative trends along the matrix;   detect at least one pattern along the matrix comprised of a plurality of combinations of positive and/or negative trends evolving in timed relation to each other; and   output an alarm upon the detection of the at least one pattern.   
     
     
         20 . The medical alarm system of  claim 19 , wherein the at least one pattern is representative of at least one of sepsis, severe sepsis, septic shock, a shock cascade, and a septic shock cascade. 
     
     
         21 . A medical alarm system for warning healthcare workers and for processing at least physiologic and laboratory data of at least one patient comprising a computer programmed with executable instructions to:
 identify positive and/or negative trends comprising at least a combination of inflammatory indicator trends with at least one of, a metabolic trend, pulse trend, blood pressure trend, oxygen saturation trend, and ventilation trend;   identify a relational pattern of the positive and/or negative trends which are indicative of progression of sepsis to a more life threatening state; and   output an alarm in response to identification of the relational pattern.   
     
     
         22 . A medical alarm system for warning healthcare workers and for processing at least physiologic and laboratory data of at least one patient comprising a computer programmed with executable instructions to:
 convert at least the physiologic and laboratory data into a predetermined format favorable for searching;   searching the physiologic and laboratory data in the predetermined format;   detecting a progressively expanding pattern of abnormal data characteristics of at least sepsis and/or septic shock; and   outputting an alarm in response to detection of the progressively expanding pattern.   
     
     
         23 . The medical alarm system of  claim 22 , wherein the predetermined format is comprised of trends. 
     
     
         24 . The medical alarm system of  claim 22 , wherein the predetermined format is a time-series matrix. 
     
     
         25 . The medical alarm system of  claim 22 , wherein the predetermined format is a time-series matrix of trends. 
     
     
         26 . The medical alarm system of  claim 22 , wherein the predetermined format is an objectified time-series matrix. 
     
     
         27 . The medical alarm system of  claim 22 , wherein the predetermined format is a time-series matrix of objectified trends.