Pharmaceutical composition comprising fermented ginseng

Abstract

A process for preparing a processed ginseng extract with enhanced pharmacological effects due to subsequent treatment is disclosed. The subsequent treatment includes an acid-treatment of ginseng and a bio-converting treatment, such as a lactic acid bacterial fermenting and an intestinal bacterial fermenting process.

1 . A pharmaceutical composition comprising:
 a mixture of a plurality of saponin compounds selected from the group consisting of ginsenoside Rb 1 , ginsenoside Rb 2 , ginsenoside Rc, ginsenoside Rd, ginsenoside Re, ginsenoside Rg 3 , ginsenoside F2, ginsenoside Rh 2 , compound K and protopanaxadiol;   wherein ginsenoside Rh 2  and ginsenoside Rg 3  are present in the largest amounts.   
   
   
       2 . The pharmaceutical composition of  claim 1  further comprising a pharmaceutically acceptable carrier. 
   
   
       3 . The pharmaceutical composition of  claim 2  wherein the pharmaceutically acceptable carrier is selected from the group consisting of lactose, dextrose, sucrose, sorbitol, mannitol, xylitol erythritol, maltitol, starches, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, polyvinyl pyrrolidone, water, methylhydroxy benzoate, propylhydroxy benzoate, talc, magnesium stearate and mineral oil. 
   
   
       4 . The pharmaceutical composition of  claim 2  wherein the pharmaceutically acceptable carrier is a solvent. 
   
   
       5 . The pharmaceutical composition of  claim 4  wherein the solvent is selected from the group consisting of physiological saline, polyethylene glycol, ethanol, vegetable oil, and isopropyl myristate. 
   
   
       6 . The pharmaceutical composition of  claim 2  in an oral dosage form selected from the group consisting of powder, tablet, capsule, soft capsule, aqueous medicine, syrup, elixirs pill, powder, sachet and granule. 
   
   
       7 . The pharmaceutical composition of  claim 2  in a topical preparation form selected from the group consisting of cream, ointment, lotion, gel, balm, patch, paste, spray solution, aerosol. 
   
   
       8 . The pharmaceutical composition of  claim 2  in an injectable form selected from the group consisting of solution, suspension and emulsion. 
   
   
       9 . The pharmaceutical composition of  claim 2  wherein the mixture of a plurality of saponin compounds comprises 0.01 to 80 w/w % of the total weight of the pharmaceutical composition. 
   
   
       10 . The pharmaceutical composition of  claim 1  wherein ginsenoside Rh 2  comprises approximately 45% of the to the total saponin compounds in the mixture. 
   
   
       11 . A pharmaceutical composition comprising:
 a mixture of a plurality of saponin compounds selected from the group consisting of ginsenoside Rb 1 , ginsenoside Rb 2 , ginsenoside Rc, ginsenoside Rd, ginsenoside Re, ginsenoside Rg 3 , ginsenoside F2, ginsenoside Rh 2 , compound K and protopanaxadiol;   wherein ginsenoside Rh 2  is present in the largest amount.   
   
   
       12 . The pharmaceutical composition of  claim 11  further comprising a pharmaceutically acceptable carrier. 
   
   
       13 . The pharmaceutical composition of  claim 12  wherein the pharmaceutically acceptable carrier is selected from the group consisting of lactose, dextrose, sucrose, sorbitol, mannitol, xylitol erythritol, maltitol, starches, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, polyvinyl pyrrolidone, water, methylhydroxy benzoate, propylhydroxy benzoate, talc, magnesium stearate and mineral oil. 
   
   
       14 . The pharmaceutical composition of  claim 12  wherein the pharmaceutically acceptable carrier is a solvent. 
   
   
       15 . The pharmaceutical composition of  claim 14  wherein the solvent is selected from the group consisting of physiological saline, polyethylene glycol, ethanol, vegetable oil, and isopropyl myristate. 
   
   
       16 . The pharmaceutical composition of  claim 12  in an oral dosage form selected from the group consisting of powder, tablet, capsule, soft capsule, aqueous medicine, syrup, elixirs pill, powder, sachet and granule. 
   
   
       17 . The pharmaceutical composition of  claim 12  in a topical preparation form selected from the group consisting of cream, ointment, lotion, gel, balm, patch, paste, spray solution, aerosol. 
   
   
       18 . The pharmaceutical composition of  claim 12  in an injectable form selected from the group consisting of solution, suspension and emulsion. 
   
   
       19 . The pharmaceutical composition of  claim 12  wherein the mixture of a plurality of saponin compounds comprises 0.01 to 80 w/w % of the total weight of the pharmaceutical composition. 
   
   
       20 . The pharmaceutical composition of  claim 11  wherein ginsenoside Rh 2  comprises approximately 45% of the to the total saponin compounds in the mixture.