US2010081696A1PendingUtilityA1
Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment
Est. expiryJan 24, 2022(expired)· nominal 20-yr term from priority
A61P 35/04A61P 9/08A61P 9/04A61P 37/08A61P 7/02A61P 37/02A61P 43/00A61P 9/10A61P 37/06A61P 29/00A61P 25/04A61P 25/20A61P 27/06A61P 3/10A61P 25/06A61P 27/16A61P 27/02A61P 29/02A61P 35/00A61P 19/10A61P 11/06A61P 13/08A61P 19/02A61P 19/08A61P 11/02A61P 11/00A61P 15/00A61P 15/06A61P 19/00C07D 209/88C07D 209/80A61K 31/404
67
PatentIndex Score
0
Cited by
0
References
0
Claims
Abstract
Fluoro substituted cycloalkanoindole derivatives are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases.
Claims
exact text as granted — not AI-modified1 . A pharmaceutical composition comprising a compound of formula I:
and pharmaceutically acceptable salts thereof, wherein
n is 0 or 1; m is 1, 2 or 3; R 1 is H, C 1 -C 3 alkyl, halogenated C 1 -C 3 alkyl or cyclopropyl;
R 2 is 4-chlorophenyl or 2,4,6-trichlorophenyl,
and nicotinic acid and a pharmaceutically acceptable carrier.
2 . The composition of claim 1 wherein n is 0.
3 . The composition of claim 1 wherein n is 1.
4 . The composition of claim 1 wherein m is 1.
5 . The composition of claim 1 wherein m is 2.
6 . The composition of claim 1 wherein R 1 is H.
7 . The compound composition of claim 1 wherein R 1 is CH 3 .
8 . The composition of claim 1 wherein R 2 is 4-chloro-phenyl.
9 . The composition of claim 1 wherein R 2 is 2,4,6-trichlorophenyl.
10 . The composition of claim 1 wherein the compound of Formula I has the stereoconfiguration shown below:
11 . The composition of claim 10 wherein n is 0.
12 . The composition of claim 10 wherein n is 1.
13 . The composition of claim 10 wherein in is 1.
14 . The composition of claim 10 wherein m is 2.
15 . The composition of claim 10 wherein R 1 is H.
16 . The composition of claim 10 wherein R 1 is CH 3 .
17 . The composition of claim 10 wherein R 2 is 4-chloro-phenyl.
18 . The composition of claim 10 wherein R 2 is 2,4,6-trichlorophenyl.
19 . (canceled)
20 . (canceled)
21 . (canceled)
22 . (canceled)
23 . (canceled)
24 . (canceled)
25 . (canceled)
26 . (canceled)
27 . (canceled)
28 . (canceled)
29 . (canceled)Cited by (0)
No later patents cite this yet.
References (0)
No backward citations on record.