Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues

Abstract

The present invention provides pharmaceutical compositions containing hydroxystilbenes or their derivatives or analogues. The pharmaceutical compositions are useful for protein kinase inhibition, and for treatment of psoriasis, eczema and inflammation.

1 . A pharmaceutical composition comprising a compound of Formula I: 
     
       
         
         
             
             
         
       
       wherein 
       R is selected from the group consisting of halogen; 
       alkyl with carbon between 1 to 18; 
       alkenyl with carbon between 1 to 18; 
       R 1  and R 2  are independently selected from the group consisting of hydrogen; 
       alkyl with carbon between 1 to 18; 
       acyl with carbon between 1 to 18; 
       or pharmaceutically acceptable salts thereof. 
     
   
   
       2 . The pharmaceutical composition according to  claim 1 , wherein in Formula I R 1  and R 2  are hydrogen and R is an alkyl group. 
   
   
       3 . The pharmaceutical composition according to  claim 2  comprising 3,5-dihydroxy-4-isopropylstilbene. 
   
   
       4 . The pharmaceutical composition according to  claim 2  comprising 3,5-diacetoxy-4-isopropylstilbene. 
   
   
       5 . The pharmaceutical composition according to  claim 1  wherein it is useful for protein kinase inhibition. 
   
   
       6 . The pharmaceutical composition according to  claim 5  wherein the protein kinase is Lck, DNA-Pk, Pim-1 or Ck2. 
   
   
       7 . The pharmaceutical composition according to  claim 1  wherein it is useful for treating psoriasis. 
   
   
       8 . The pharmaceutical composition according to  claim 1  wherein it is useful for treating eczema. 
   
   
       9 . The pharmaceutical composition according to  claim 1  wherein it is useful for treating inflammation.