Compositions and methods for surface abrasion with frozen particles

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

1 - 81 . (canceled) 
     
     
         82 . A method for abrasion of at least one biological tissue surface of a subject, comprising:
 delivering at least one composition to at least one surface of at least one biological tissue of a subject in a manner sufficient to abrade the at least one surface of the at least one biological tissue;   wherein the at least one composition includes one or more frozen particles, including at least one of hydrogen oxide, helium, neon, krypton, argon, xenon, nitrogen, chlorine, bromine, oxygen, air, or carbon dioxide;   wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less; and   wherein the at least one composition includes one or more reinforcement agents.   
     
     
         83 . The method of  claim 82 , wherein the one or more frozen particles are in one or more phases including ice Ic. 
     
     
         84 . The method of  claim 82 , wherein delivering at least one composition to at least one biological tissue includes propelling the composition toward the at least one biological tissue. 
     
     
         85 . The method of  claim 84 , wherein the at least one composition is propelled at a predetermined pressure for delivery of the at least one composition to a desired location on or in the at least one biological tissue. 
     
     
         86 . (canceled) 
     
     
         87 . The method of  claim 84 ; wherein the at least one composition is propelled to a predetermined velocity for delivery of the at least one composition to a desired location of the at least one biological tissue. 
     
     
         88 - 92 . (canceled) 
     
     
         93 . The method of  claim 82 , wherein the delivering at least one composition to at least one biological tissue includes propelling, ejecting, or accelerating multiple frozen particles toward the at least one biological tissue. 
     
     
         94 - 98 . (canceled) 
     
     
         99 . The method of  claim 82 , further comprising extracting or collecting material from the at least one abraded surface of at least one biological tissue. 
     
     
         100 - 102 . (canceled) 
     
     
         103 . The method of  claim 82 , wherein the at least one biological tissue is located in at least one of in situ, in vitro, in vivo, in utero, in planta, in silico, or ex vivo. 
     
     
         104 . (canceled) 
     
     
         105 . The method of  claim 103 , wherein the at least one biological tissue is located in at least one tissue or organ related to transplantation. 
     
     
         106 . The method of  claim 105 , wherein the at least one tissue or organ related to transplantation includes at least one donor or recipient tissue or organ. 
     
     
         107 . (canceled) 
     
     
         108 . The method of  claim 103 , wherein the at least one biological tissue is ingested by at least one subject. 
     
     
         109 . (canceled) 
     
     
         110 . The method of  claim 82 , wherein the at least one biological tissue includes at least one cell mass. 
     
     
         111 - 114 . (canceled) 
     
     
         115 . The method of  claim 82 , further comprising delivering to the at least one biological tissue at least one of a polymer, biopolymer, nanoparticle, or detection material. 
     
     
         116 - 118 . (canceled) 
     
     
         119 . The method of  claim 115 , wherein the detection material includes at least one electronic identification device. 
     
     
         120 . (canceled) 
     
     
         121 . The method of  claim 115 , wherein the detection material includes at least one radioactive element. 
     
     
         122 . (canceled) 
     
     
         123 . The method of  claim 115 , wherein the detection material includes at least one colorimetric substance. 
     
     
         124 - 127 . (canceled) 
     
     
         128 . The method of  claim 115 , wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle. 
     
     
         129 . The method of  claim 82 , wherein the subject includes at least one invertebrate or vertebrate animal. 
     
     
         130 - 133 . (canceled) 
     
     
         134 . The method of  claim 82 , wherein the at least one composition further comprises one or more explosive materials. 
     
     
         135 . (canceled) 
     
     
         136 . A method for abrasion of at least one biological tissue surface of a subject, comprising:
 delivering at least one composition to at least one surface of at least one biological tissue of a subject in a manner sufficient to abrade the at least one surface of the at least one biological tissue;   wherein the at least one composition includes one or more frozen particles, including at least one of hydrogen oxide, helium, neon, krypton, argon, xenon, nitrogen, chlorine, bromine, oxygen, air, or carbon dioxide;   wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less; and   wherein the at least one composition includes one or more explosive materials.   
     
     
         137 . The method of  claim 136 , wherein the one or more frozen particles are in one or more phases including ice Ic. 
     
     
         138 . The method of  claim 136 , wherein delivering at least one composition to at least one biological tissue includes propelling the composition toward the at least one biological tissue. 
     
     
         139 . The method of  claim 138 , wherein the at least one composition is propelled to a predetermined pressure for delivery of the at least one composition to a desired location on or in the at least one biological tissue. 
     
     
         140 . (canceled) 
     
     
         141 . The method of  claim 138 , wherein the at least one composition is propelled to a predetermined velocity for delivery of the at least one composition to a desired location of the at least one biological tissue. 
     
     
         142 - 146 . (canceled) 
     
     
         147 . The method of  claim 136 , wherein the delivering at least one composition to at least one biological tissue includes propelling, ejecting, or accelerating multiple frozen particles toward the at least one biological tissue. 
     
     
         148 - 152 . (canceled) 
     
     
         153 . The method of  claim 136 , further comprising extracting or collecting material from the at least one abraded surface of at least one biological tissue. 
     
     
         154 - 156 . (canceled) 
     
     
         157 . The method of  claim 136 , wherein the at least one biological tissue is located in at least one of in situ, in vitro, in vivo, in utero, in planta, in silico, or ex vivo. 
     
     
         158 . (canceled) 
     
     
         159 . The method of  claim 157 , wherein the at least one biological tissue is located in at least one tissue or organ related to transplantation. 
     
     
         160 . The method of  claim 159 , wherein the at least one tissue or organ related to transplantation includes at least one donor or recipient tissue or organ. 
     
     
         161 . (canceled) 
     
     
         162 . The method of  claim 157 , wherein the at least one biological tissue is ingested by at least one subject. 
     
     
         163 . (canceled) 
     
     
         164 . The method of  claim 136 , wherein the at least one biological tissue includes at least one cell mass. 
     
     
         165 - 168 . (canceled) 
     
     
         169 . The method of  claim 136 , further comprising delivering to the at least one biological tissue at least one of a polymer, biopolymer, nanoparticle, or detection material. 
     
     
         170 - 172 . (canceled) 
     
     
         173 . The method of  claim 169 , wherein the detection material includes at least one electronic identification device. 
     
     
         174 . (canceled) 
     
     
         175 . The method of  claim 169 , wherein the detection material includes at least one radioactive element. 
     
     
         176 . (canceled) 
     
     
         177 . The method of  claim 169 ; wherein the detection material includes at least one colorimetric substance. 
     
     
         178 - 181 . (canceled) 
     
     
         182 . The method of  claim 169 , wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle. 
     
     
         183 . The method of  claim 136 , wherein the subject includes at least one invertebrate or vertebrate animal. 
     
     
         184 - 187 . (canceled) 
     
     
         188 . The method of  claim 136 , wherein the at least one composition further comprises one or more reinforcement agents. 
     
     
         189 . (canceled) 
     
     
         190 . A method for debridement of at least one biological tissue of a subject, comprising:
 delivering at least one composition to at least one biological tissue of a subject in a manner sufficient to remove dead, damaged or infected tissue of the at least one biological tissue,   wherein the at least one composition includes one or more frozen particles, including at least one of hydrogen oxide, helium, neon, krypton, argon, xenon, nitrogen, chlorine, bromine, oxygen, air, or carbon dioxide;   wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less; and   wherein the at least one composition includes one or more reinforcement agents.   
     
     
         191 - 203 . (canceled) 
     
     
         204 . A method for debridement of at least one biological tissue of a subject, comprising:
 delivering at least one composition to at least one biological tissue of a subject in a manner sufficient to remove dead, damaged or infected tissue of the at least one biological tissue,   wherein the at least one composition includes one or more frozen particles, including at least one of hydrogen oxide, helium, neon, krypton, argon, xenon, nitrogen, chlorine, bromine, oxygen, air, or carbon dioxide;   wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less; and   wherein the at least one composition includes one or more explosive materials.   
     
     
         205 - 237 . (canceled) 
     
     
         238 . A method for cleaning one or more wounds of a subject, comprising:
 delivering at least one composition to one or more wounds in a manner sufficient to clean the one or more wounds,   wherein the at least one composition includes one or more frozen particles, including at least one of hydrogen oxide, helium, neon, krypton, argon, xenon, nitrogen, chlorine, bromine, oxygen, air, or carbon dioxide;   wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less; and   wherein the at least one composition includes one or more reinforcement agents.   
     
     
         239 - 243 . (canceled) 
     
     
         244 . A method for cleaning one or more wounds of a subject, comprising:
 delivering at least one composition to one or more wounds in a manner sufficient to clean the one or more wounds,   wherein the at least one composition includes one or more frozen particles, including at least one of hydrogen oxide, helium, neon, krypton, argon, xenon, nitrogen, chlorine, bromine, oxygen, air, or carbon dioxide;   wherein the one or more frozen particles have at least one major dimension of approximately one centimeter or less; and   wherein the at least one composition includes one or more explosive materials.   
     
     
         245 - 256 . (canceled)