Inhibitors of 11-beta-hydroxy steriod dehydrogenase type 1

Abstract

The present invention relates to compounds with the formula (II) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

1 . A compound of the formula (II) 
     
       
         
         
             
             
         
       
       wherein 
       T is an aryl ring or heteroaryl ring or aryl-C 2 -alkenyl ring, optionally independently substituted by [R] n , wherein n is an integer 0-5, and R is hydrogen, aryl, heteroaryl, a heterocyclic ring, optionally halogenated C 1-6 -alkyl, optionally halogenated C 1-6 -alkoxy, C 1-6 -alkylsulfonyl, carboxy, cyano, nitro, halogen, amine which is optionally mono- or di-substituted, amide which is optionally mono- or di-substituted, aryloxy, arylsulfonyl, arylamino, wherein aryl, heteroaryl and aryloxy residues and heterocyclic rings can further be optionally substituted in one or more positions independently of each other by C 1-6 -acyl, C 1-6 -alkylthio, cyano, nitro, hydrogen, halogen, optionally halogenated C 1-6 -alkyl, optionally halogenated C 1-6 -alkoxy, amide which is optionally mono- or di-substituted, (benzoylamino)methyl, carboxy, 2-thienylmethylamino or ({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}carbonyl); 
       with the proviso that when R 1  is H, X is CH 2 , Y is CO, R 2  is EtO and B is H, then T is not 2,4-dichloro-5-methylphenyl, 4-chlorophenyl, 4-chloro-2,5-dimethylphenyl, 2,4-difluorophenyl, 3-nitrophenyl and phenyl; 
       R 1  is hydrogen or C 1-6 -alkyl; 
       X is CH 2  or CO; 
       Y is CH 2 , CO or a single bond; 
       B is hydrogen, C 1-6 -alkyl or dimethylaminomethyl; 
       R 2  is selected from C 1-6 -alkyl, azido, arylthio, heteroarylthio, halogen, hydroxymethyl, 2-hydroxyethylaminomethyl, methylsulfonyloxymethyl, 3-oxo-4-morpholinolinylmethylene, C 1-6 -alkoxycarbonyl, 5-methyl-1,3,4-oxadiazol-2-yl; 
       NR 3 R 4 , wherein R 3  and R 4  are each independently selected from hydrogen, C 1-6 -alkyl, optionally halogenated C 1-6 -alkylsulfonyl, C 1-6 -alkoxy, 2-methoxyethyl, 2-hydroxyethyl, 1-methylimidazolylsulfonyl, C 1-6 -acyl, cyclohexylmethyl, cyclopropanecarbonyl, aryl, optionally halogenated arylsulfonyl, furylcarbonyl, tetrahydro-2-furanylmethyl, N-carbethoxypiperidyl, or C 1-6 -alkyl substituted with one or more aryl or heteroaryl, or 
       NR 3 R 4  represent together heterocyclic systems which can be imidazole, piperidine, pyrrolidine, piperazine, morpholine, oxazepine, oxazole, thiomorpholine, 1,1-dioxidothiomorpholine, 2-(3,4-dihydro-2(1H)isoquinolinyl), (1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl, which heterocyclic systems can be optionally substituted by C 1-6 -alkyl, C 1-6 -acyl, hydroxy, oxo, t-butoxycarbonyl; 
       OCONR 3 R 4 , wherein R 3  and R 4  are each independently selected from hydrogen, C 1-6 -alkyl or form together morpholinyl; 
       R 5 O, wherein R 5  is hydrogen, optionally halogenated C 1-6 -alkyl, aryl, heteroaryl, C 1-6 -acyl, C 1-6 -alkylsulfonyl, arylcarbonyl, heteroarylcarbonyl, 2-carbomethoxyphenyl; or a salt, hydrate or solvate thereof. 
     
   
   
       2 . A compound according to  claim 1 ,
 wherein   T is selected from 5-chloro-1,3-dimethyl-1H-pyrazol-4-yl; 4-chloro-2,3,1-benzoxadiazolyl; 5-(dimethylamino)-1-naphthyl; 1-methylimidazol-4-yl; 1-naphthyl; 2-naphthyl; (E)-2-phenylethenyl; 8-quinolinyl;   thienyl substituted with one or more of (benzoylamino)methyl, bromo, chloro, 3-isoxazolyl, 2-(methylsulfanyl)-4-pyrimidinyl, 1-methyl-5-(trifluoromethyl)pyrazol-3-yl, phenylsulfonyl, pyridyl;   phenyl substituted with one or more of acetylamino, 3-acetylaminophenyl, 3-acetylphenyl, benzeneamino, 1,3-benzodioxol-5-yl, 2-benzofuryl, benzylamino, 3,5-bis(trifluoromethyl)phenyl, bromo, butoxy, carboxy, chloro, 4-carboxyphenyl, 3-chloro-2-cyanophenoxy, 4-chlorophenyl, 5-chloro-2-thienyl, cyano, 3,4-dichlorophenyl, ({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}carbonyl), fluoro, 5-fluoro-2-methoxyphenyl, 2-furyl, hydrogen, iodo, isopropyl, methanesulfonyl, methoxy, methyl, 4-methyl-1-piperazinyl, 4-methyl-1-piperidinyl, 4-methylsulfanylphenyl, 5-methyl-2-thienyl, 4-morpholinyl, nitro, 3-nitrophenyl, phenoxy, phenyl, n-propyl, 4-pyridyl, 3-pyridylmethylamino, 1-pyrrolidinyl, 2-thienyl, 3-thienyl, 2-thienylmethylamino, trifluoromethoxy, 4-trifluoromethoxyphenyl, trifluoromethyl; or   with the proviso that when R 1  is H, X is CH 2 , Y is CO, R 2  is EtO and B is H, then T is not 2,4-dichloro-5-methylphenyl, 4-chlorophenyl, 4-chloro-2,5-dimethylphenyl, 2,4-difluorophenyl, 3-nitrophenyl and phenyl;   R 1  is hydrogen or methyl;   X is CH 2  or CO;   Y is CH 2 , CO or a single bond;   B is hydrogen, methyl or dimethylaminomethyl;   R 2  is selected from   n-propyl, azido, bromo, chloro, 2-pyridinylsulfanyl, 3-oxo-4-morpholinolinyl-methylene, ethoxycarbonyl, 5-methyl-1,3,4-oxadiazol-2-yl, hydroxymethyl, 2-hydroxyethylaminomethyl, methylsulfonyloxymethyl;   NR 3 R 4 , wherein R 3  and R 4  are each independently selected from acetyl, benzhydryl, 1,3-benzodioxol-5-ylmethyl, benzyl, 3-chloro-2-methylphenylsulfonyl, cyclohexyl, cyclohexylmethyl, cyclopropanecarbonyl, ethyl, 2-furylcarbonyl, 2-furylmethyl, hydrogen, 2-hydroxyethyl, 2-(1H-indol-3-yl)ethyl, isopropyl, methoxy, 2-methoxyethyl, methyl, 4-(1-methylimidazolyl)sulfonyl, methylsulfonyl, phenyl, (1S)-phenylethyl, n-propyl, tetrahydro-2-furanylmethyl, trifluoromethylsulfonyl, N-carbethoxypiperidyl; or   NR 3 R 4  represent together 4-acetylpiperazinyl, 4-t-butoxycarbonylpiperazinyl, 2-(3,4-dihydro-2(1H)isoquinolinyl), (2R,6S)-2,6-dimethylmorpholinyl, (2R)-2,4-dimethyl-1-piperazinyl, 2-hydroxy-3-oxomorpholinyl, imidazolyl, 2-methyl-3-oxomorpholinyl, 4-methyl-2-oxopiperazinyl, 4-methylpiperazinyl, morpholinyl, (1S,4S)-2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl, 2-oxoimidazolinyl, 3-oxomorpholinyl, 3-oxo-1,4-oxazepinyl, 2-oxooxazolinyl, piperazinyl; piperidinyl; pyrrolidinyl; pyrrolidonyl, thiomorpholinyl; 1,1-dioxido-thiomorpholinyl;   OCONR 3 R 4 , wherein R 3  and R 4  are each independently selected from ethyl, hydrogen or form together morpholinyl;   R 5 O, wherein R 5  is acetyl, benzoyl, benzyl, ethyl, 2-fluoroethyl, 2-furylcarbonyl, hydrogen, isobutyryl, isopropyl, methyl, 2-carbomethoxyphenyl, methylsulfonyl, phenyl, propionyl, 3-pyridinyl, 2,2,2-trifluoroethyl.   
   
   
       3 . A compound of  claim 1 - 2  selected from the group consisting of:
 Ethyl 2-(2-(((4-methylphenyl)sulfonyl)amino)-1,3-thiazol-4-yl)acetate,   Ethyl 2-(2-{[(2,5-dichloro-3-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-{2-[([1′-biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl 2-(2-{[(3-bromophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-nitrophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-methoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-fluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-fluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-isopropylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[3-({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}carbonyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[4-({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}carbonyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(2-methylphenyl)sulfonyl]amino)}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[2-(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[3-(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[4-(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl 2-(2-{[(4-bromophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-nitrophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(5-fluoro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-methoxy-4-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3,5-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(3-chloro-2-cyanophenoxy)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(3,4-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-butoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(acetylamino)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl {2-[(8-quinolinylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(3,4-dimethoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-iodophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-chloro-4-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(5-bromo-2-methoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,5-dimethoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[(2-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl {2-[(mesitylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(3-bromo-5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[({5-[(benzoylamino)methyl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl {2-[({5-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(4-cyanophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[({5-[2-(methylsulfanyl)-4-pyrimidinyl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(3-cyanophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4,5-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[(E)-2-phenylethenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(2,3,4-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-bromo-2,5-difluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(2,3-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-bromophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4,5-dichloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(phenylsulfonyl)-2-thienyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[5-(phenylsulfonyl)-2-thienyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(2,6-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-cyanophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(acetylamino)-3-chlorophenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-methoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-bromo-5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(2,5-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(methylsulfonyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[2-(methylsulfonyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(4-bromo-2-fluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,3,4-trifluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(7-chloro-2,1,3-benzoxadiazol-4-yl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4,6-trifluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   2-Chloro-5-({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}sulfonyl)-4-fluorobenzoic acid,   Ethyl (2-{[(5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[5-(3-isoxazolyl)-2-thienyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(4-bromo-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-phenoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-chloro-2,6-dimethylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[2-methyl-4-(trifluoromethoxy)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[2,4-bis(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl 2-{2-[[(3-chloro-2-methylphenyl)sulfonyl](methyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl oxo(2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)(oxo)acetate,   Ethyl oxo(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[([1,1′-biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}(oxo)acetate,   Ethyl (2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)(oxo)acetate,   2-(2-{[(4-Methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetic acid,   2-(2-{[(2,5-Dichloro-3-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetic acid,   (2-{[(2-Chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetic acid,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetic acid,   Isopropyl 2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Phenyl 2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Methyl (2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Methyl {2-[([1,1′-biphenyl]-4-ylsulfonyl)amino]-5-methyl-1,3-thiazol-4-yl}acetate,   Methyl (2-{[(4-chlorophenyl)sulfonyl]amino}-5-methyl-1,3-thiazol-4-yl)acetate,   Methyl (2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-5-methyl-1,3-thiazol-4-yl)acetate,   Methyl [2-({[4-(3-chloro-2-cyanophenoxy)phenyl]sulfonyl}amino)-5-methyl-1,3-thiazol-4-yl]acetate;   Methyl (5-methyl-2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Methyl (5-methyl-2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Methyl (2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-5-methyl-1,3-thiazol-4-yl)acetate,   N-(2-Methoxyethyl)-2-(2-{[(4-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(2,5-Dichloro-3-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methylacetamide,   N-(1,3-Benzodioxol-5-ylmethyl)-2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   N-(2-Furylmethyl)-2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   2-(2-{[(2,4-Difluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethylacetamide,   N-Isopropyl-2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   N-[2-(1H-Indol-3-yl)ethyl]-2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   N-(Cyclohexylmethyl)-2-{2-[(phenylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-phenylacetamide,   2-(2-{[(4-Chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-(2-furylmethyl)acetamide,   N-Benzhydryl-2-(2-{[(4-chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(4-Chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-(tetrahydro-2-furanylmethyl)acetamide,   Ethyl 4-{[2-(2-{[(4-chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetyl]amino)}-1-piperidinecarboxylate,   N-Benzhydryl-2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(4-Chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-phenylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino)}-1,3-thiazol-4-yl)-N,N-diethylacetamide,   2-{2-[([1,1′-Biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}-N,N-diethylacetamide,   N,N-diethyl-2-(2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(2,4-Dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-diethylacetamide,   N,N-diethyl-2-(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-{2-[([1,1′-Biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}-N,N-diisopropylacetamide,   N,N-diisopropyl-2-(2-{[(4-propylphenyl)sulfonyl]amino)}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(2,4-Dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-diisopropylacetamide,   N,N-diisopropyl-2-(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-diisopropylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-dipropylacetamide,   N-benzyl-2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methylacetamide,   N-benzyl-2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-dimethylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-cyclohexyl-N-methylacetamide,   3-Chloro-N-{4-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methyl-N-phenylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-isopropyl-N-methylacetamide,   2-{2-[([1,1′-Biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}-N-isopropyl-N-methylacetamide,   N-ethyl-N-methyl-2-(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(2,4-Dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethyl-N-methylacetamide,   N-ethyl-N-methyl-2-(2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-{2-[([1,1′-Biphenyl]-4-ylsulfonyl)amino}-1,3-thiazol-4-yl]-N-ethyl-N-methylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethyl-N-methylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methyl-N-[(1S)-1-phenylethyl]acetamide,   3-Chloro-2-methyl-N-{4-[2-oxo-2-(1-pyrrolidinyl)ethyl] j -1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4,6-Trichloro-N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4,6-Trichloro-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide,   2,4-Dichloro-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-Chloro-2,6-dimethyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-phenoxybenzenesulfonamide,   2-Methyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(trifluoromethoxy)benzenesulfonamide,   N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-2,4-bis(trifluoromethyl)benzenesulfonamide,   4-Bromo-2-methyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide, 4-(2-Furyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3′-Fluoro-6′-methoxy-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   4-(5-Methyl-2-thienyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3′-Acetyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4′-(trifluoromethoxy)[1,1′-biphenyl]-4-sulfonamide,   3′,4′-Dichloro-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   4-(1,3-Benzodioxol-5-yl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-(5-chloro-2-thienyl)-N-{4-[2-(4-morphinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(4-pyridinyl)benzenesulfonamide,   N-{4′-[({4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}amino)sulfonyl][1,1′-biphenyl]-3-yl}acetamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(3-thienyl)benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(2-thienyl)benzenesulfonamide,   4′-[({4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}amino)sulfonyl][1,1′ biphenyl]-4-carboxylic acid,   4′-(Methylsulfanyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-3′,5′-bis(trifluoromethyl)[1,1′-biphenyl]-4-sulfonamide,   4′-Chloro-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-3′-nitro[1,1′-biphenyl]-4-sulfonamide,   4-(1-Benzofuran-2-yl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(1-pyrrolidinyl)benzenesulfonamide,   4-(4-Methyl-1-piperidinyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-Anilino-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-(B enzylamino)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-[(2-thienylmethyl)amino]benzenesulfonamide,   4-(4-Morpholinyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-(4-Methyl-1-piperazinyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-[(3-pyridinylmethyl)amino]benzenesulfonamide,   2,4-Dichloro-6-methyl-N-{5-methyl-4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{5-methyl-4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   2,4,6-Dichloro-N-{5-methyl-4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-chloro-2-methyl-N-{5-methyl-4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-N-(4-{2-[(2R,6S)-2,6-dimethylmorpholinyl]-2-oxoethyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-(4-{2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl]-2-oxoethyl}-1,3-thiazol-2-yl)benzenesulfonamide, 3-Chloro-2-methyl-N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4,6-Trichloro-N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(1,1-dioxido-4-thiomorpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide,   Tert-butyl 4-[(2-1{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetyl]-1-piperazinecarboxylate,   N-{4-[2-(4-Acetyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-3-chloro-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide trifluoro acetate,   3-Chloro-2-methyl-N-{4-[2-oxo-2-(1-piperazinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide trifluoroacetate,   2-Methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(trifluoromethoxy)benzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4-Dichloro-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-chloro-N-(4-{2-[(2R)-2,4-dimethylpiperazinyl]-2-oxoethyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methoxy-N-methylacetamide,   3-Chloro-2-methyl-N-[4-(2-oxopentyl)-1,3-thiazol-2-yl]benzeliesulfonamide,   4-Chloro-N-[4-(2-hydroxyethyl)-1,3-thiazol-2-yl]benzenesulfonamide,   3-Chloro-N-[4-(2-hydroxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(3-hydroxypropyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(2-ethoxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(2-isopropoxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   N-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-chloro-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(2-methoxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-N-{4-[2-(2-fluoroethoxy)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2,2,2-trifluoroethoxy)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-pyridinylsulfanyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(3-pyridinyloxy)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   Methyl 2-[2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethoxy]benzoate,   3-Chloro-N-[5-[(dimethylamino)methyl]-4-(2-ethoxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl methanesulfonate,   3-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)propyl methanesulfonate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl acetate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl propionate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl 2-methylpropanoate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl 2-furoate,   2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl benzoate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl 4-morpholinecarboxylate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl diethylcarbamate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl ethylcarbamate,   N-[4-(2-azidoethyl)-1,3-thiazol-2-yl]-3-chloro-2-methylbenzenesulfonamide,   N-[4-(2-aminoethyl)-1,3-thiazol-2-yl]-3-chloro-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(methylamino)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-Chloro-N-{4-[2-(diethylamino)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   3-Chloro-N-{4-[2-(diethylamino)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide hydrochloride,   3-Chloro-N-{4-[2-(1H-imidazol-1-yl)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide dihydrate, 3-Chloro-2-methyl-N-{4-[2-(4-methyl-1-piperazinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide dihydrochloride,   3-Chloro-2-methyl-N-{4-[2-(4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   3-Chloro-2-methyl-N-[4-(4-morpholinylmethyl)-1,3-thiazol-2-yl]benzenesulfonamide hydrochloride,   2,4,6-Trichloro-N-{4-[2-(4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   2,4-Dichloro-N-{4-[2-(4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   2,4-Dichloro-6-methyl-N-{4-[2-(4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   N-{4-[2-(4-Morpholinyl)ethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide hydrochloride,   3-Chloro-N-{4-[2-(ethylamino)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide,   3-Chloro-N-(4-{2-[(2-hydroxyethyl)amino]ethyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,   3-Chloro-N-(4-{(3-[(2-hydroxyethyl)amino]propyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide hydrochloride hydrate, N-[2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino)}-1,3-thiazol-4-yl)ethyl]-N-ethylacetamide,   3-Chloro-2-methyl-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-N-{4-[2-(2-hydroxy-3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide,   2,4-Dichloro-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4,6-Trichloro-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4,5-Dichloro-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}-2-thiophenesulfonamide,   N-{4-[2-(3-Oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}-4-phenoxybenzenesulfonamide,   3-Fluoro-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(3-Oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}-5-(2-pyridinyl)-2-thiophenesulfonamide,   N-{2-Chloro-4-[({4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}amino)sulfonyl]phenyl}acetamide,   3-Chloro-2-methyl-N-{4-[(3-oxo-4-morpholinyl)methyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[3-(3-oxo-4-morpholinyl)propyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-N,2-dimethyl-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-methyl-3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide, N-[2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]acetamide,   3-Chloro-2-methyl-N-{4-[2-(3-oxo-1,4-oxazepan-4-yl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-oxo-1-pyrrolidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-oxo-1-imidazolidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-oxo-1,3-oxazolidin-3-yl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-[2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]-N-(2-hydroxyethyl)-2-furamide,   N-[2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]-N-methylcyclopropanecarboxamide,   3-Chloro-2-methyl-N-{4-[2-(4-methyl-2-oxo-1-piperazinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   3-Chloro-2-methyl-N-(4-{2-[(methylsulfonyl)amino]ethyl}-1,3-thiazol-2-yl)benzenesulfonamide,   3-Chloro-2-methyl-N-(4-{2-[methyl(methylsulfonyl)amino]ethyl}-1,3-thiazol-2-yl)benzenesulfonamide,   3-Chloro-2-methyl-N-[4-(2-{[(trifluoromethyl)sulfonyl]amino}ethyl)-1,3-thiazol-2-yl]benzenesulfonamide,   3-Chloro-2-methyl-N-[4-(2-{methyl[(trifluoromethyl)sulfonyl]amino}ethyl)-1,3-thiazol-2-yl]benzenesulfonamide,   N-[2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]-1-methyl-1H-imidazole-4-sulfonamide,   3-Chloro-N-(4-{2-[[(3-chloro-2-methylphenyl)sulfonyl](methyl)amino]ethyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,   N-[4-(2-bromoethyl)-1,3-thiazol-2-yl]-3-chloro-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(2-chloroethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-{4-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1,3-thiazol-2-yl}benzenesulfonamide,   Ethyl 3-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)propanoate.   
   
   
       4 . A compound according to anyone of  claims 1 - 3 , for medical use. 
   
   
       5 . A process for the preparation of a compound according to  claim 1 - 3  comprising at least one of the following steps:
 a) sulfonamide coupling by reacting a 2-aminothiazole with a sulfonylchloride in the presence of a base,   b) sulfonamide coupling by reacting a 2-aminothiazole derivative with a sulfonylchloride in the presence of a base,   c) saponification by treatment of a carboxylic acid ester with aqueous hydroxide,   d) amide coupling by reacting a carboxylic acid ester with an amine,   e) amide coupling by reacting a carboxylic acid with an amine in the presence of EDCI,   f) amide coupling by reacting a carboxylic acid with an amine in the presence of EDCI, HOAT or HOBT,   g) amide coupling by reacting a carboxylic acid ester with an amine in the presence of aluminium chloride,   h) formation of a thiazole ring by reacting an optionally substituted thiourea with an α-haloketone,   i) formation of a thiazole ring by reacting a thiourea with a ketone,   j) acylation of an alcohol by reacting with an acid chloride in the presence of a base,   k) carbamoylation of an alcohol by reacting with 4-nitrophenylchloroformate and then with a primary or secondary amine,   l) palladium coupling of a halo compound with a boronic acid,   m) palladium coupling of a halo compound with an amine with 18-crown-6,   n) palladium coupling of a halo compound with an amine without 18-crown-6.   
   
   
       6 . A method for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, dementia, depression, virus diseases and inflammatory disorders, said method comprising administering to a mammal, including man, in need of such treatment an effective amount of a compound of the formula (II) 
     
       
         
         
             
             
         
       
       wherein 
       T is an aryl ring or heteroaryl ring or aryl-C 2 -alkenyl ring, optionally independently substituted by [R] n , wherein n is an integer 0-5, and R is hydrogen, aryl, heteroaryl, a heterocyclic ring, optionally halogenated C 1-6 -alkyl, optionally halogenated C 1-6 -alkoxy, C 1-6 -alkylsulfonyl, carboxy, cyano, nitro, halogen, amine which is optionally 20, mono- or di-substituted, amide which is optionally mono- or di-substituted, aryloxy, arylsulfonyl, arylamino, wherein aryl, heteroaryl and aryloxy residues and heterocyclic rings can further be optionally substituted in one or more positions independently of each other by C 1-6 -acyl, C 1-6 -alkylthio, cyano, nitro, hydrogen, halogen, optionally halogenated C 1-6 -alkyl, optionally halogenated C 1-6 -alkoxy, amide which is optionally mono- or di-substituted, (benzoylamino)methyl, carboxy, 2-thienylmethylamino or ({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}carbonyl); 
       R 1  is hydrogen or C 1-6 -alkyl; 
       X is CH 2  or CO; 
       Y is CH 2 , CO or a single bond; 
       B is hydrogen, C 1-6 -alkyl or dimethylaminomethyl; 
       R 2  is selected from C 1-6 -alkyl, azido, arylthio, heteroarylthio, halogen, hydroxymethyl, 2-hydroxyethylaminomethyl, methylsulfonyloxymethyl, 3-oxo-4-morpholinolinylmethylene, C 1-6 -alkoxycarbonyl, 5-methyl-1,3,4-oxadiazol-2-yl; 
       NR 3 R 4 , wherein R 3  and R 4  are each independently selected from hydrogen, C 1-6 -alkyl, optionally halogenated C 1-6 -alkylsulfonyl, C 1-6 -alkoxy, 2-methoxyethyl, 2-hydroxyethyl, 1-methylimidazolylsulfonyl, C 1-6 -acyl, cyclohexylmethyl, cyclopropanecarbonyl, aryl, optionally halogenated arylsulfonyl, furylcarbonyl, tetrahydro-2-furanylmethyl, N-carbethoxypiperidyl or C 1-6 -alkyl substituted with one or more aryl or heteroaryl, or 
       NR 3 R 4  represent together heterocyclic systems which can be imidazole, piperidine, pyrrolidine, piperazine, morpholine, oxazepine, oxazole, thiomorpholine, 1,1-dioxidothiomorpholine, 2-(3,4-dihydro-2(1H)isoquinolinyl), (1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl, which heterocyclic systems can be optionally substituted by C 1-6 -alkyl, C 1-6 -acyl, hydroxy, oxo, t-butoxycarbonyl; 
       OCONR 3 R 4 , wherein R 3  and R 4  are each independently selected from hydrogen, C 1-6 -alkyl or form together morpholinyl; 
       R 5 O, wherein R 5  is hydrogen, optionally halogenated C 1-6 -alkyl, aryl, heteroaryl, C 1-6 -acyl, C 1-6 -alkylsulfonyl, arylcarbonyl, heteroarylcarbonyl, 2-carbomethoxyphenyl; or a salt, hydrate or solvate thereof. 
     
   
   
       7 . A method according to  claim 6 , wherein
 T is selected from 5-chloro-1,3-dimethyl-1H-pyrazol-4-yl; 4-chloro-2,3,1-benzoxadiazolyl; 5-(dimethylamino)-1-naphthyl; 1-methylimidazol-4-yl; 1-naphthyl; 2-naphthyl; (E)-2-phenylethenyl; 8-quinolinyl;   thienyl substituted with one or more of (benzoylamino)methyl, bromo, chloro, 3-isoxazolyl, 2-(methylsulfanyl)-4-pyrimidinyl, 1-methyl-5-(trifluoromethyl)pyrazol-3-yl, phenylsulfonyl, pyridyl;   phenyl substituted with one or more of acetylamino, 3-acetylaminophenyl, 3-acetylphenyl, benzeneamino, 1,3-benzodioxol-5-yl, 2-benzofuryl, benzylamino, 3,5-bis(trifluoromethyl)phenyl, bromo, butoxy, carboxy, chloro, 4-carboxyphenyl, 3-chloro-2-cyanophenoxy, 4-chlorophenyl, 5-chloro-2-thienyl, cyano, 3,4-dichlorophenyl, ({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}carbonyl), fluoro, 5-fluoro-2-methoxyphenyl, 2-furyl, hydrogen, iodo, isopropyl, methanesulfonyl, methoxy, methyl, 4-methyl-1-piperazinyl, 4-methyl-1-piperidinyl, 4-methylsulfanylphenyl, 5-methyl-2-thienyl, 4-morpholinyl, nitro, 3-nitrophenyl, phenoxy, phenyl, n-propyl, 4-pyridyl, 3-pyridylmethylamino, 1-pyrrolidinyl, 2-thienyl, 3-thienyl, 2-thienylmethylamino, trifluoromethoxy, 4-trifluoromethoxyphenyl, trifluoromethyl; or   R 1  is hydrogen or methyl;   X is CH 2  or CO;   Y is CH 2 , CO or a single bond;   B is hydrogen, methyl or dimethylaminomethyl;   R 2  is selected from   n-propyl, azido, bromo, chloro, 2-pyridinylsulfanyl, 3-oxo-4-morpholinolinyl-methylene, ethoxycarbonyl, 5-methyl-1,3,4-oxadiazol-2-yl, hydroxymethyl, 2-hydroxyethylaminomethyl, methylsulfonyloxymethyl;   NR 3 R 4 , wherein R 3  and R 4  are each independently selected from acetyl, benzhydryl, 1,3-benzodioxol-5-ylmethyl, benzyl, 3-chloro-2-methylphenylsulfonyl, cyclohexyl, cyclohexylmethyl, cyclopropanecarbonyl, ethyl, 2-furylcarbonyl, 2-furylmethyl, hydrogen, 2-hydroxyethyl, 2-(1H-indol-3-yl)ethyl, isopropyl, methoxy, 2-methoxyethyl, methyl, 4-(1-methylimidazolyl)sulfonyl, methylsulfonyl, phenyl, (1S)-phenylethyl, n-propyl, tetrahydro-2-furanylmethyl, trifluoromethylsulfonyl, N-carbethoxypiperidyl; or   NR 3 R 4  represent together 4-acetylpiperazinyl, 4-t-butoxycarbonylpiperazinyl, 2-(3,4-dihydro-2(1H)isoquinolinyl), (2R,6S)-2,6-dimethylmorpholinyl, (2R)-2,4-dimethyl-1-piperazinyl, 2-hydroxy-3-oxomorpholinyl, imidazolyl, 2-methyl-3-oxomorpholinyl, 4-methyl-2-oxopiperazinyl, 4-methylpiperazinyl, morpholinyl, (1S,4S)-2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl, 2-oxoimidazolinyl, 3-oxomorpholinyl, 3-oxo-1,4-oxazepinyl, 2-oxooxazolinyl, piperazinyl; piperidinyl; pyrrolidinyl; pyrrolidonyl, thiomorpholinyl; 1,1-dioxido-thiomorpholinyl;   OCONR 3 R 4 , wherein R 3  and R 4  are each independently selected from ethyl, hydrogen or form together morpholinyl;   R 5 O, wherein R 5  is acetyl, benzoyl, benzyl, ethyl, 2-fluoroethyl, 2-furylcarbonyl, hydrogen, isobutyryl, isopropyl, methyl, 2-carbomethoxyphenyl, methylsulfonyl, phenyl, propionyl, 3-pyridinyl, 2,2,2-trifluoroethyl.   
   
   
       8 . A method according to  claim 6 - 7 , wherein the compound is selected from:
 Ethyl (2-{[(2,4-dichloro-5-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-(2-[[(4-chlorophenyl)sulfonyl]amino]-1,3-thiazole-4-yl)acetate,   Ethyl 2-(2-{[(4-chloro-2,5-dimethylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-(2-{[(2,4-difluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-(2-(((4-methylphenyl)sulfonyl)amino)-1,3-thiazol-4-yl)acetate,   Ethyl 2-(2-{[(2,5-dichloro-3-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-{2-[([1,1′-biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl 2-(2-{[(3-bromophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-nitrophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-methoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-nitrophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-fluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-fluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[(phenylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(4-isopropylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[3-({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}carbonyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[4-({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}carbonyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[2-(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[3-(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[4-(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl 2-(2-{[(4-bromophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-nitrophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(5-fluoro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-methoxy-4-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3,5-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(3-chloro-2-cyanophenoxy)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(3,4-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-butoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(acetylamino)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl {2-[(8-quinolinylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(3,4-dimethoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-iodophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-chloro-4-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(5-bromo-2-methoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,5-dimethoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[(2-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl {2-[(mesitylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(3-bromo-5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[({5-[(benzoylamino)methyl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl {2-[({5-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(4-cyanophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[({5-[2-(methylsulfanyl)-4-pyrimidinyl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(3-cyanophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4,5-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[(E)-2-phenylethenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(2,3,4-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-bromo-2,5-difluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(2,3-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-bromophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4,5-dichloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(phenylsulfonyl)-2-thienyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[5-(phenylsulfonyl)-2-thienyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(2,6-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-cyanophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(acetylamino)-3-chlorophenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-methoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-bromo-5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(2,5-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(methylsulfonyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[2-(methylsulfonyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(4-bromo-2-fluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,3,4-trifluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(7-chloro-2,1,3-benzoxadiazol-4-yl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4,6-trifluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   2-Chloro-5-({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}sulfonyl)-4-fluorobenzoic acid,   Ethyl (2-{[(5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[5-(3-isoxazolyl)-2-thienyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(4-bromo-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-phenoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-chloro-2,6-dimethylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[2-methyl-4-(trifluoromethoxy)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[2,4-bis(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl 2-{2-[[(3-chloro-2-methylphenyl)sulfonyl](methyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl oxo(2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)(oxo)acetate,   Ethyl oxo(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[([1,1′-biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}(oxo)acetate,   Ethyl (2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)(oxo)acetate,   2-(2-{[(4-Methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetic acid,   2-(2-{[(2,5-Dichloro-3-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetic acid,   (2-{[(2-Chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetic acid,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetic acid,   Isopropyl 2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Phenyl 2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Methyl (2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Methyl {2-[([1,1′-biphenyl]-4-ylsulfonyl)amino]-5-methyl-1,3-thiazol-4-yl}acetate,   Methyl (2-{[(4-chlorophenyl)sulfonyl]amino}-5-methyl-1,3-thiazol-4-yl)acetate,   Methyl (2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-5-methyl-1,3-thiazol-4-yl)acetate,   Methyl [2-({[4-(3-chloro-2-cyanophenoxy)phenyl]sulfonyl}amino)-5-methyl-1,3-thiazol-4-yl]acetate,   Methyl (5-methyl-2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Methyl (5-methyl-2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Methyl (2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-5-methyl-1,3-thiazol-4-yl)acetate,   N-(2-Methoxyethyl)-2-(2-{[(4-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(2,5-Dichloro-3-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methylacetamide,   N-(1,3-Benzodioxol-5-ylmethyl)-2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   N-(2-Furylmethyl)-2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   2-(2-{[(2,4-Difluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethylacetamide,   N-Isopropyl-2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   N-[2-(1H-Indol-3-yl)ethyl]-2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   N-(Cyclohexylmethyl)-2-{2-[(phenylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-triazol-4-yl)-N-phenylacetamide,   2-(2-{[(4-Chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-(2-furylmethyl)acetamide,   N-Benzhydryl-2-(2-{[(4-chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(4-Chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-(tetrahydro-2-furanylmethyl)acetamide,   Ethyl 4-{[2-(2-{[(4-chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetyl]amino}-1-piperidinecarboxylate,   N-Benzhydryl-2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(4-Chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-phenylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-diethylacetamide,   2-{2-[([1,1′-Biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}-N,N-diethylacetamide,   N,N-diethyl-2-(2-{[(4-propylphenyl)sulfonyl]amino)}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(2,4-Dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-diethylacetamide,   N,N-diethyl-2-(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-{2-[([1,1′-Biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}-N,N-diisopropylacetamide,   N,N-diisopropyl-2-(2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(2,4-Dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-diisopropylacetamide,   N,N-diisopropyl-2-(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-diisopropylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino)}-1,3-thiazol-4-yl)-N,N-dipropylacetamide,   N-benzyl-2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methylacetamide,   N-benzyl-2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-dimethylacetamide,   2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-cyclohexyl-N-methylacetamide,   3-Chloro-N-{4-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methyl-N-phenylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-isopropyl-N-methylacetamide,   2-{2-[([1,1′-Biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}-N-isopropyl-N-methylacetamide,   N-ethyl-N-methyl-2-(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(2,4-Dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethyl-N-methylacetamide,   N-ethyl-N-methyl-2-(2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-{2-[([1,1′-Biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}-N-ethyl-N-methylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethyl-N-methylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methyl-N-[(1S)-1-phenylethyl]acetamide,   3-Chloro-2-methyl-N-{4-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4,6-Trichloro-N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4,6-Trichloro-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide,   2,4-Dichloro-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-Chloro-2,6-dimethyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-phenoxybenzenesulfonamide,   2-Methyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(trifluoromethoxy)benzenesulfonamide,   N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-2,4-bis(trifluoromethyl)benzenesulfonamide,   4-Bromo-2-methyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-(2-Furyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3′-Fluoro-6′-methoxy-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   4-(5-Methyl-2-thienyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3′-Acetyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4′-(trifluoromethoxy)[1,1′-biphenyl]-4-sulfonamide,   3′,4′-Dichloro-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   4-(1,3-Benzodioxol-5-yl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-(5-chloro-2-thienyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(4-pyridinyl)benzenesulfonamide,   N-{4′-[({4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}amino)sulfonyl][1,1′-biphenyl]-3-yl}acetamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(3-thienyl)benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(2-thienyl)benzenesulfonamide,   4′-[({4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}amino)sulfonyl][1,1′-biphenyl]-4-carboxylic acid,   4′-(Methylsulfanyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-3′,5′-bis(trifluoromethyl)[1,1′-biphenyl]-4-sulfonamide,   4′-Chloro-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-3′-nitro[1,1′-biphenyl]-4-sulfonamide,   4-(1-Benzofuran-2-yl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(1-pyrrolidinyl)benzenesulfonamide,   4-(4-Methyl-1-piperidinyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-Anilino N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-(Benzylamino)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide, N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-[(2-thienylmethyl)amino]benzenesulfonamide,   4-(4-Morpholinyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-(4-Methyl-1-piperazinyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-[(3-pyridinylmethyl)amino]benzenesulfonamide,   2,4-Dichloro-6-methyl-N-{5-methyl-4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{5-methyl-4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   2,4,6-trichloro-N-{5-methyl-4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-chloro-2-methyl-N-{5-methyl-4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-N-(4-{2-[(2R,6S)-2,6-dimethylmorpholinyl]-2-oxoethyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-(4-{2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl]-2-oxoethyl}-1,3-thiazol-2-yl)benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4,6-Trichloro-N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(1,1-dioxido-4-thiomorpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide,   Tert-butyl 4-[(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetyl]-1-piperazinecarboxylate,   N-{4-[2-(4-Acetyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-3-chloro-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide trifluoro acetate,   3-Chloro-2-methyl-N-{4-[2-oxo-2-(1-piperazinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide trifluoroacetate,   2-Methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(trifluoromethoxy)benzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4-Dichloro-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-chloro-N-(4-{2-[(2R)-2,4-dimethylpiperazinyl]-2-oxoethyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methoxy-N-methylacetamide, 3-Chloro-2-methyl-N-[4-(2-oxopentyl)-1,3-thiazol-2-yl]benzenesulfonamide,   4-Chloro-N-[4-(2-hydroxyethyl)-1,3-thiazol-2-yl]benzenesulfonamide,   3-Chloro-N-[4-(2-hydroxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(3-hydroxypropyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(2-ethoxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(2-isopropoxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   N-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-chloro-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(2-methoxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-N-{4-[2-(2-fluoroethoxy)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2,2,2-trifluoroethoxy)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-pyridinylsulfanyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(3-pyridinyloxy)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide, Methyl 2-[2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethoxy]benzoate,   3-Chloro-N-[5-[(dimethylamino)methyl]-4-(2-ethoxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   2-2{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl methanesulfonate,   3-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)propyl methanesulfonate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl acetate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl propionate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl 2-methylpropanoate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl 2-furoate, 2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl benzoate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl 4-morpholinecarboxylate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl diethylcarbamate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl ethylcarbamate,   N-[4-(2-azidoethyl)-1,3-thiazol-2-yl]-3-chloro-2-methylbenzenesulfonamide,   N-[4-(2-aminoethyl)-1,3-thiazol-2-yl]-3-chloro-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(methylamino)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-Chloro-N-{4-[2-(diethylamino)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   3-Chloro-N-{4-[2-(diethylamino)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide hydrochloride,   3-Chloro-N-{4-[2-(1H-imidazol-1-yl)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide dihydrate, 3-Chloro-2-methyl-N-{4-[2-(4-methyl-1-piperazinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide dihydrochloride,   3-Chloro-2-methyl-N-{4-[2-(4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   3-Chloro-2-methyl-N-[4-(4-morpholinylmethyl)-1,3-thiazol-2-yl]benzenesulfonamide hydrochloride,   2,4,6-Trichloro-N-{4-[2-(4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   2,4-Dichloro-N-{4-[2-(4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   2,4-Dichloro-6-methyl-N-{4-[2-(4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   N-{4-[2-(4-Morpholinyl)ethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide hydrochloride,   3-Chloro-N-{4-[2-(ethylamino)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide,   3-Chloro-N-(4-{2-[(2-hydroxyethyl)amino]ethyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,   3-Chloro-N-(4-{3-[(2-hydroxyethyl)amino]propyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide hydrochloride hydrate, N-[2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]-N-ethylacetamide,   3-Chloro-2-methyl-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-N-{4-[2-(2-hydroxy-3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide,   2,4-Dichloro-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4,6-Trichloro-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4,5-Dichloro-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}-2-thiophenesulfonamide,   N-{4-[2-(3-Oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}-4-phenoxybenzenesulfonamide,   3-Fluoro-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(3-Oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}-5-(2-pyridinyl)-2-thiophenesulfonamide,   N-{2-Chloro-4-[({4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}amino)sulfonyl]phenyl}acetamide,   3-Chloro-2-methyl-N-{4-[(3-oxo-4-morpholinyl)methyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[3-(3-oxo-4-morpholinyl)propyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-N,2-dimethyl-N-{4-[2-(3-oxo-4-morpholinyl)ethyl] j -1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-methyl-3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-[2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]acetamide,   3-Chloro-2-methyl-N-{4-[2-(3-oxo-1,4-oxazepan-4-yl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-oxo-1-pyrrolidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-oxo-1-imidazolidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-oxo-1,3-oxazolidin-3-yl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-[2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]-N-(2-hydroxyethyl)-2-furamide,   N-[2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]-N-methylcyclopropanecarboxamide,   3-Chloro-2-methyl-N-{4-[2-(4-methyl-2-oxo-1-piperazinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   3-Chloro-2-methyl-N-(4-{2-[(methylsulfonyl)amino]ethyl}-1,3-thiazol-2-yl)benzenesulfonamide,   3-Chloro-2-methyl-N-(4-{2-[methyl(methylsulfonyl)amino]ethyl}-1,3-thiazol-2-yl)benzenesulfonamide,   3-Chloro-2-methyl-N-[4-(2-{[(trifluoromethyl)sulfonyl]amino}ethyl)-1,3-thiazol-2-yl]benzenesulfonamide,   3-Chloro-2-methyl-N-[4-(2-{methyl[(trifluoromethyl)sulfonyl]amino}ethyl)-1,3-thiazol-2-yl]benzenesulfonamide,   N-[2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]-1-methyl-1H-imidazole-4-sulfonamide,   3-Chloro-N-(4-{2-[[(3-chloro-2-methylphenyl)sulfonyl](methyl)amino]ethyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,   N-[4-(2-bromoethyl)-1,3-thiazol-2-yl]-3-chloro-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(2-chloroethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-{4-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1,3-thiazol-2-yl}benzenesulfonamide,   Ethyl 3-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)propanoate.   
   
   
       9 . The use of a compound of the formula (II) 
     
       
         
         
             
             
         
       
       wherein 
       T is an aryl ring or heteroaryl ring or aryl-C 2 -alkenyl ring, optionally independently substituted by [R] n , wherein n is an integer 0-5, and R is hydrogen, aryl, heteroaryl, a heterocyclic ring, optionally halogenated C 1-6 -alkyl, optionally halogenated C 1-6 -alkoxy, C 1-6 -alkylsulfonyl, carboxy, cyano, nitro, halogen, amine which is optionally mono- or di-substituted, amide which is optionally mono- or di-substituted, aryloxy, arylsulfonyl, arylamino, wherein aryl, heteroaryl and aryloxy residues and heterocyclic rings can further be optionally substituted in one or more positions independently of each other by C 1-6 -acyl, C 1-6 -alkylthio, cyano, nitro, hydrogen, halogen, optionally halogenated C 1-6 -alkyl, optionally halogenated C 1-6 -alkoxy, amide which is optionally mono- or di-substituted, (benzoylamino)methyl, carboxy, 2-thienylmethylamino or ({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}carbonyl); 
       R 1  is hydrogen or C 1-6 -alkyl; 
       X is CH 2  or CO; 
       Y is CH 2 , CO or a single bond; 
       B is hydrogen, C 1-6 -alkyl or dimethylaminomethyl; 
       R 2  is selected from C 1-6 -alkyl, azido, arylthio, heteroarylthio, halogen, hydroxymethyl, 2-hydroxyethylaminomethyl, methylsulfonyloxymethyl, 3-oxo-4-morpholinolinylmethylene, C 1-6 -alkoxycarbonyl, 5-methyl-1,3,4-oxadiazol-2-yl; 
       NR 3 R 4 , wherein R 3  and R 4  are each independently selected from hydrogen, C 1-6 -alkyl, optionally halogenated C 1-6 -alkylsulfonyl, C 1-6 -alkoxy, 2-methoxyethyl, 2-hydroxyethyl, 1-methylimidazolylsulfonyl, C 1-6 -acyl, cyclohexylmethyl, cyclopropanecarbonyl, aryl, optionally halogenated arylsulfonyl, furylcarbonyl, tetrahydro-2-furanylmethyl, N-carbethoxypiperidyl, or C 1-6 -alkyl substituted with one or more aryl or heteroaryl, or 
       NR 3 R 4  represent together heterocyclic systems which can be imidazole, piperidine, pyrrolidine, piperazine, morpholine, oxazepine, oxazole, thiomorpholine, 1,1-dioxidothiomorpholine, 2-(3,4-dihydro-2(1H)isoquinolinyl), (1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl, which heterocyclic systems can be optionally substituted by C 1-6 -alkyl, C 1-6 -acyl, hydroxy, oxo, t-butoxycarbonyl; 
       OCONR 3 R 4 , wherein R 3  and R 4  are each independently selected from hydrogen, C 1-6 -alkyl or form together morpholinyl; 
       R 5 O, wherein R 5  is hydrogen, optionally halogenated C 1-6 -alkyl, aryl, heteroaryl, C 1-6 -acyl, C 1-6 -alkylsulfonyl, arylcarbonyl, heteroarylcarbonyl, 2-carbomethoxyphenyl; 
       or a salt, hydrate or solvate thereof, 
       in the manufacture of a medicament for the prevention, management or treatment of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, dementia, depression, virus diseases and inflammatory disorders. 
     
   
   
       10 . The use according to  claim 9 , wherein
 T is selected from 5-chloro-1,3-dimethyl-1H-pyrazol-4-yl; 4-chloro-2,3,1-benzoxadiazolyl; 5-(dimethylamino)-1-naphthyl; 1-methylimidazol-4-yl; 1-naphthyl; 2-naphthyl; (E)-2-phenylethenyl; 8-quinolinyl;   thienyl substituted with one or more of (benzoylamino)methyl, bromo, chloro, 3-isoxazolyl, 2-(methylsulfanyl)-4-pyrimidinyl, 1-methyl-5-(trifluoromethyl)pyrazol-3-yl, phenylsulfonyl, pyridyl;   phenyl substituted with one or more of acetylamino, 3-acetylaminophenyl, 3-acetylphenyl, benzeneamino, 1,3-benzodioxol-5-yl, 2-benzofuryl, benzylamino, 3,5-bis(trifluoromethyl)phenyl, bromo, butoxy, carboxy, chloro, 4-carboxyphenyl, 3-chloro-2-cyanophenoxy, 4-chlorophenyl, 5-chloro-2-thienyl, cyano, 3,4-dichlorophenyl, ({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}carbonyl), fluoro, 5-fluoro-2-methoxyphenyl, 2-furyl, hydrogen, iodo, isopropyl, methanesulfonyl, methoxy, methyl, 4-methyl-1-piperazinyl, 4-methyl-1-piperidinyl, 4-methylsulfanylphenyl, 5-methyl-2-thienyl, 4-morpholinyl, nitro, 3-nitrophenyl, phenoxy, phenyl, n-propyl, 4-pyridyl, 3-pyridylmethylamino, 1-pyrrolidinyl, 2-thienyl, 3-thienyl, 2-thienylmethylamino, trifluoromethoxy, 4-trifluoromethoxyphenyl, trifluoromethyl; or   R 1  is hydrogen or methyl;   X is CH 2  or CO;   Y is CH 2 , CO or a single bond;   B is hydrogen, methyl or dimethylaminomethyl;   R 2  is selected from   n-propyl, azido, bromo, chloro, 2-pyridinylsulfanyl, 3-oxo-4-morpholinolinyl-methylene, ethoxycarbonyl, 5-methyl-1,3,4-oxadiazol-2-yl, hydroxymethyl, 2-hydroxyethylaminomethyl, methylsulfonyloxymethyl;   NR 3 R 4 , wherein R 3  and R 4  are each independently selected from acetyl, benzhydryl, 1,3-benzodioxol-5-ylmethyl, benzyl, 3-chloro-2-methylphenylsulfonyl, cyclohexyl, cyclohexylmethyl, cyclopropanecarbonyl, ethyl, 2-furylcarbonyl, 2-furylmethyl, hydrogen, 2-hydroxyethyl, 2-(1H-indol-3-yl)ethyl, isopropyl, methoxy, 2-methoxyethyl, methyl, 4-(1-methylimidazolyl)sulfonyl, methylsulfonyl, phenyl, (1S)-phenylethyl, n-propyl, tetrahydro-2-furanylmethyl, trifluoromethylsulfonyl, N-carbethoxypiperidyl; or   NR 3 R 4  represent together 4-acetylpiperazinyl, 4-t-butoxycarbonylpiperazinyl, 2-(3,4-dihydro-2(1H)isoquinolinyl), (2R,6S)-2,6-dimethylmorpholinyl, (2R)-2,4-dimethyl-1-piperazinyl, 2-hydroxy-3-oxomorpholinyl, imidazolyl, 2-methyl-3-oxomorpholinyl, 4-methyl-2-oxopiperazinyl, 4-methylpiperazinyl, morpholinyl, (1S,4S)-2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl, 2-oxoimidazolinyl, 3-oxomorpholinyl, 3-oxo-1,4-oxazepinyl, 2-oxooxazolinyl, piperazinyl; piperidinyl; pyrrolidinyl; pyrrolidonyl, thiomorpholinyl; 1,1-dioxido-thiomorpholinyl;   OCONR 3 R 4 , wherein R 3  and R 4  are each independently selected from ethyl, hydrogen or form together morpholinyl;   R 5 O, wherein R 5  is acetyl, benzoyl, benzyl, ethyl, 2-fluoroethyl, 2-furylcarbonyl, hydrogen, isobutyryl, isopropyl, methyl, 2-carbomethoxyphenyl, methylsulfonyl, phenyl, propionyl, 3-pyridinyl, 2,2,2-trifluoroethyl.   
   
   
       11 . The use according to  claim 9 - 10 , wherein the compound is selected from:
 Ethyl (2-{[(2,4-dichloro-5-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-(2-[[(4-chlorophenyl)sulfonyl]amino]-1,3-thiazole-4-yl)acetate,   Ethyl 2-(2-{[(4-chloro-2,5-dimethylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-(2-{[(2,4-difluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-(2-(((4-methylphenyl)sulfonyl)amino)-1,3-thiazol-4-yl)acetate,   Ethyl 2-(2-{[(2,5-dichloro-3-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-{2-[([1,1′-biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl 2-(2-{[(3-bromophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-nitrophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-methoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-nitrophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-fluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-fluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[(phenylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(4-isopropylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[3-({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}carbonyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[4-({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}carbonyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[2-(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[3-(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[4-(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl 2-(2-{[(4-bromophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-nitrophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(5-fluoro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-methoxy-4-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3,5-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(3-chloro-2-cyanophenoxy)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(3,4-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-butoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(acetylamino)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl {2-[(8-quinolinylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(3,4-dimethoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-iodophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-chloro-4-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(5-bromo-2-methoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,5-dimethoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[(2-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl {2-[(mesitylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(3-bromo-5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[({5-[(benzoylamino)methyl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl {2-[({5-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(4-cyanophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[({5-[2-(methylsulfanyl)-4-pyrimidinyl]-2-thienyl}sulfonyl)amino]-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-cyanophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4,5-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[(E)-2-phenylethenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(2,3,4-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-bromo-2,5-difluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(2,3-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-bromophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4,5-dichloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(phenylsulfonyl)-2-thienyl]sulfonyl}amino)-1,3-thiazol-4-yl)]acetate,   Ethyl [2-({[5-(phenylsulfonyl)-2-thienyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(2,6-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-cyanophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(acetylamino)-3-chlorophenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-methoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-bromo-5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl 2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl (2-{[(2,5-dichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[4-(methylsulfonyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[2-(methylsulfonyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(4-bromo-2-fluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,3,4-trifluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(7-chloro-2,1,3-benzoxadiazol-4-yl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2,4,6-trifluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   2-Chloro-5-({[4-(2-ethoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino}sulfonyl)-4-fluorobenzoic acid,   Ethyl (2-{[(5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[5-(3-isoxazolyl)-2-thienyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl (2-{[(4-bromo-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-phenoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(4-chloro-2,6-dimethylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl [2-({[2-methyl-4-(trifluoromethoxy)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl [2-({[2,4-bis(trifluoromethyl)phenyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate,   Ethyl 2-{2-[[(3-chloro-2-methylphenyl)sulfonyl](methyl)amino]-1,3-thiazol-4-yl}acetate,   Ethyl oxo(2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl (2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)(oxo)acetate,   Ethyl oxo(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Ethyl {2-[([1,1′-biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}(oxo)acetate,   Ethyl (2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)(oxo)acetate,   2-(2-{[(4-Methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetic acid,   2-(2-{[(2,5-Dichloro-3-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetic acid,   (2-{[(2-Chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetic acid,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetic acid,   Isopropyl 2-(2-{([(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Phenyl 2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Methyl (2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Methyl {2-[([1,1′-biphenyl]-4-ylsulfonyl)amino]-5-methyl-1,3-thiazol-4-yl}acetate,   Methyl (2-{[(4-chlorophenyl)sulfonyl]amino}-5-methyl-1,3-thiazol-4-yl)acetate,   Methyl (2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-5-methyl-1,3-thiazol-4-yl)acetate,   Methyl [2-({[4-(3-chloro-2-cyanophenoxy)phenyl]sulfonyl}amino)-5-methyl-1,3-thiazol-4-yl]acetate,   Methyl (5-methyl-2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Methyl (5-methyl-2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate,   Methyl (2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-5-methyl-1,3-thiazol-4-yl)acetate,   N-(2-Methoxyethyl)-2-(2-{[(4-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(2,5-Dichloro-3-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methylacetamide,   N-(1,3-Benzodioxol-5-ylmethyl)-2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   N-(2-Furylmethyl)-2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   2-(2-{[(2,4-Difluorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethylacetamide,   N-Isopropyl-2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   N-[2-(1H-Indol-3-yl)ethyl]-2-{2-[(1-naphthylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   N-(Cyclohexylmethyl)-2-{2-[(phenylsulfonyl)amino]-1,3-thiazol-4-yl}acetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-phenylacetamide,   2-(2-{[(4-Chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-(2-furylmethyl)acetamide,   N-Benzhydryl-2-(2-{[(4-chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(4-Chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-(tetrahydro-2-furanylmethyl)acetamide,   Ethyl 4-{[2-(2-{[(4-chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetyl]amino}-1-piperidinecarboxylate,   N-Benzhydryl-2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(4-Chlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-phenylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-diethylacetamide,   2-{2-[([1,1′-Biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}-N,N-diethylacetamide,   N,N-diethyl-2-(2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(2,4-Dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-diethylacetamide,   N,N-diethyl-2-(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-{2-[([1,1′-Biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}-N,N-diisopropylacetamide,   N,N-diisopropyl-2-(2-{[(4-propylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(2,4-Dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-diisopropylacetamide,   N,N-diisopropyl-2-(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-diisopropylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-dipropylacetamide,   N-benzyl-2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methylacetamide,   N-benzyl-2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N,N-dimethylacetamide,   2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-cyclohexyl-N-methylacetamide,   3-Chloro-N-{4-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methyl-N-phenylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-isopropyl-N-methylacetamide,   2-(2-[([1,1′-Biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl)-N-isopropyl-N-methylacetamide,   N-ethyl-N-methyl-2-(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetamide,   2-(2-{[(2,4-Dichloro-6-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethyl-N-methylacetamide,   N-ethyl-N-methyl-2-(2-{[(4-propylphenyl)sulfonyl]amino)}-1,3-thiazol-4-yl)acetamide,   2-{2-[([1,1′-Biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}-N-ethyl-N-methylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-ethyl-N-methylacetamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methyl-N-[(1S)-1-phenylethyl]acetamide,   3-Chloro-2-methyl-N-{4-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4,6-Trichloro-N-{4-[2-oxo-2-(1-piperidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4,6-Trichloro-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide,   2,4-Dichloro-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-Chloro-2,6-dimethyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-phenoxybenzenesulfonamide,   2-Methyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(trifluoromethoxy)benzenesulfonamide,   N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-2,4-bis(trifluoromethyl)benzenesulfonamide,   4-Bromo-2-methyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-(2-Furyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3′-Fluoro-6′-methoxy-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   4-(5-Methyl-2-thienyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3′-Acetyl-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4′-(trifluoromethoxy)[1,1′-biphenyl] j -4-sulfonamide,   3′,4′-Dichloro-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   4-(1,3-Benzodioxol-5-yl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-(5-chloro-2-thienyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(4-pyridinyl)benzenesulfonamide,   N-{4′-[({4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}amino)sulfonyl][1,1′-biphenyl]-3-yl}acetamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(3-thienyl)benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(2-thienyl)benzenesulfonamide,   4′-[({4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}amino)sulfonyl][1,1′-biphenyl]-4-carboxylic acid,   4′-(Methylsulfanyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[ 1 , 1 ′-biphenyl]-4-sulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-3′,5′-bis(trifluoromethyl)[1,1′-biphenyl]-4-sulfonamide,   4′-Chloro-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-3′-nitro[1,1′-biphenyl]-4-sulfonamide,   4-(1-Benzofuran-2-yl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(1-pyrrolidinyl)benzenesulfonamide,   4-(4-Methyl-1-piperidinyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-Anilino-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-(Benzylamino)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-[(2-thienylmethyl)amino]benzenesulfonamide,   4-(4-Morpholinyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-(4-Methyl-1-piperazinyl)-N-{4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(4-Morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-[(3-pyridinylmethyl)amino]benzenesulfonamide,   2,4-Dichloro-6-methyl-N-{5-methyl-4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{5-methyl-4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   2,4,6-trichloro-N-{5-methyl-4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-chloro-2-methyl-N-{5-methyl-4-[2-(4-morpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-N-(4-{2-[(2R,6S)-2,6-dimethylmorpholinyl]-2-oxoethyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-(4-{2-[1(1S,4S)-2-oxa-5-azabicyclo [2.2.1]hept-5-yl]-2-oxoethyl}-1,3-thiazol-2-yl)benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}[1,1′-biphenyl]-4-sulfonamide,   N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4,6-Trichloro-N-{4-[2-oxo-2-(4-thiomorpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(1,1-dioxido-4-thiomorpholinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide,   Tert-butyl 4-[(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetyl]-1-piperazinecarboxylate,   N-{4-[2-(4-Acetyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-3-chloro-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide trifluoroacetate,   3-Chloro-2-methyl-N-{4-[2-oxo-2-(1-piperazinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide trifluoroacetate,   2-Methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}-4-(trifluoromethoxy)benzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4-Dichloro-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-chloro-N-(4-{2-[(2R)-2,4-dimethiylpiperazinyl]-2-oxoethyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)-N-methoxy-N-methylacetamide,   3-Chloro-2-methyl-N-[4-(2-oxopentyl)-1,3-thiazol-2-yl]benzenesulfonamide,   4-Chloro-N-[4-(2-hydroxyethyl)-1,3-thiazol-2-yl]benzenesulfonamide,   3-Chloro-N-[4-(2-hydroxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(3-hydroxypropyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(2-ethoxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(2-isopropoxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   N-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-chloro-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(2-methoxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-N-{4-[2-(2-fluoroethoxy)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2,2,2-trifluoroethoxy)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-pyridinylsulfanyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(3-pyridinyloxy)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   Methyl 2-[2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethoxy]benzoate,   3-Chloro-N-[5-[(dimethylamino)methyl]-4-(2-ethoxyethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl methanesulfonate,   3-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)propyl methanesulfonate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl acetate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl propionate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl 2-methylpropanoate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl 2-furoate,   2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl benzoate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl 4-morpholinecarboxylate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl diethylcarbamate,   2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl ethylcarbamate,   N-[4-(2-azidoethyl)-1,3-thiazol-2-yl]-3-chloro-2-methylbenzenesulfonamide,   N-[4-(2-aminoethyl)-1,3-thiazol-2-yl]-3-chloro-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(methylamino)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4-Chloro-N-{4-[2-(diethylamino)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   3-Chloro-N-{4-[2-(diethylamino)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide hydrochloride,   3-Chloro-N-{4-[2-(1H-imidazol-1-yl)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide dihydrate, 3-Chloro-2-methyl-N-{4-[2-(4-methyl-1-piperazinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide dihydrochloride,   3-Chloro-2-methyl-N-{4-[2-(4-morpholinyl)ethyl]-11,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   3-Chloro-2-methyl-N-[4-(4-morpholinylmethyl)-1,3-thiazol-2-yl]benzenesulfonamide hydrochloride,   2,4,6-Trichloro-N-{4-[2-(4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   2,4-Dichloro-N-{4-[2-(4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   2,4-Dichloro-6-methyl-N-{4-[2-(4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   N-{4-[2-(4-Morpholinyl)ethyl]-1,3-thiazol-2-yl}-4-propylbenzenesulfonamide hydrochloride,   3-Chloro-N-{4-[2-(ethylamino)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide,   3-Chloro-N-(4-{2-[(2-hydroxyethyl)amino]ethyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,   3-Chloro-N-(4-{3-[(2-hydroxyethyl)amino]propyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide hydrochloride hydrate,   N-[2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]-N-ethylacetamide,   3-Chloro-2-methyl-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-N-{4-[2-(2-hydroxy-3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}-2-methylbenzenesulfonamide,   2,4-Dichloro-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4-Dichloro-6-methyl-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   2,4,6-Trichloro-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   4,5-Dichloro-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}-2-thiophenesulfonamide,   N-{4-[2-(3-Oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}-4-phenoxybenzenesulfonamide,   3-Fluoro-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-{4-[2-(3-Oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}-5-(2-pyridinyl)-2-thiophenesulfonamide,   N-{[2-Chloro-4-[({4-2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}amino)sulfonyl]phenyl}acetamide,   3-Chloro-2-methyl-N-{4-[(3-oxo-4-morpholinyl)methyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[3-(3-oxo-4-morpholinyl)propyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-N,2-dimethyl-N-{4-[2-(3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-methyl-3-oxo-4-morpholinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-[2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]acetamide,   3-Chloro-2-methyl-N-{4-[2-(3-oxo-1,4-oxazepan-4-yl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-oxo-1-pyrrolidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-oxo-1-imidazolidinyl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   3-Chloro-2-methyl-N-{4-[2-(2-oxo-1,3-oxazolidin-3-yl)ethyl]-1,3-thiazol-2-yl}benzenesulfonamide,   N-[2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]-N-(2-hydroxyethyl)-2-furamide,   N-[2-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]-N-methylcyclopropanecarboxamide,   3-Chloro-2-methyl-N-{4-[2-(4-methyl-2-oxo-1-piperazinyl)ethyl]. 1,3-thiazol-2-yl}benzenesulfonamide hydrochloride,   3-Chloro-2-methyl-N-(4-{2-[(methylsulfonyl)amino]ethyl}-1,3-thiazol-2-yl)benzenesulfonamide,   3-Chloro-2-methyl-N-(4-{2-[methyl(methylsulfonyl)amino]ethyl}-1,3-thiazol-2-yl)benzenesulfonamide,   3-Chloro-2-methyl-N-[4-(2-{[(trifluoromethyl)sulfonyl]amino}ethyl)-1,3-thiazol-2-yl]benzenesulfonamide,   3-Chloro-2-methyl-N-[4-(2-{methyl[(trifluoromethyl)sulfonyl]amino}ethyl)-1,3-thiazol-2-yl]benzenesulfonamide,   N-[2-(2-{[(3-Chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)ethyl]-1-methyl-1H-imidazole-4-sulfonamide,   3-Chloro-N-(4-{2-[[(3-chloro-2-methylphenyl)sulfonyl](methyl)amino]ethyl}-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,   N-[4-(2-bromoethyl)-1,3-thiazol-2-yl]-3-chloro-2-methylbenzenesulfonamide,   3-Chloro-N-[4-(2-chloroethyl)-1,3-thiazol-2-yl]-2-methylbenzenesulfonamide,   3-Chloro-2-methyl-N-{4-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-1,3-thiazol-2-yl}benzenesulfonamide,   Ethyl 3-(2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)propanoate.   
   
   
       12 . A pharmaceutical composition comprising at least one compound of the formula (II) as defined in any of the  claims 9 - 11 , and a pharmaceutically acceptable carrier.