Monoacetyldiacylglycerol Derivative for the Treatment of Sepsis

Abstract

The uses of mono acetyl diacyl glycerol derivatives extracted from deer antler for immunomodulating agent disclosed. Medical supplies and health foods containing the same as an effective ingredient also disclosed. Mono acetyl diacyl glycerol derivatives shows significantly effect for immuno modulation including immune enhancing. In the case of inducing cancer in a hamster by injecting cancer cell line, cancer development was delayed by activating lymphocytes, monocytes, and dendritic cells that are important factors to promote immunity and apoptosis of cancer cell was induced by promoting cytotoxicity of immune cell against caner cell. Also in the case of mouse induced septic shock, it shows 100% survival rate even after lapse of 120 hours by control of immune function and suppression effect of apoptosis. Therefore, mono acetyl diacyl glycerol derivatives according to the present invention can be effectively used for an immunomodulating agent, a sepsis treatment, a cancer treatment, and a health food for an immune modulation or the prevention of cancer.

1 . A method of treating cancer comprising administering to a mammal an effective amount of a mono acetyl diacyl glycerol derivative of formula I: 
       
         
           
           
               
               
           
         
         wherein R1 is 9-octadecenoyl and R2 is hexadecanoyl; 
         R1 is hexadecanoyl and R2 is 9-octadecenoyl; 
         R1 is hexadecanoyl and R2 is 9,12-octadecadiennoyl; 
         R1 is hexadecanoyl and R2 is 9,12,15-octadecatriennoyl; or 
         R1 is hexadecanoyl and R2 is 5,8,11,14-eicosatetraenoyl. 
       
     
     
         2 . The method of  claim 1 , wherein the cancer is selected from the group consisting of bile duct cancer, kidney cancer and malignant melanoma.