US2010158996A1PendingUtilityA1
Ester compound and medical use thereof

Assignee: JAPAN TOBACCO INCPriority: Feb 28, 2002Filed: Feb 12, 2010Published: Jun 24, 2010
Est. expiryFeb 28, 2022(expired)· nominal 20-yr term from priority
Inventors:Atsushi Hagiwara Yasuhiro Ohe Naoya Odani Shizue Watanabe Taku Ikenogami Takashi Kawai Kenya Madono Toshio Taniguchi
A61P 43/00C07D 207/404A61P 9/12A61K 31/24C07C 2601/02C07C 235/06A61K 31/4468A61K 31/4453A61K 31/5375C07D 235/06C07D 213/55C07C 69/76C07C 235/64A61K 31/4406C07C 235/30C07D 213/82C07D 213/61C07C 235/40C07C 69/732A61K 31/216A61P 9/10A61K 31/245C07D 211/58C07D 205/12A61K 31/4184A61K 31/4015A61K 31/426A61K 31/404C07D 333/24C07C 235/16C07C 2601/14C07D 207/16C07C 2601/08C07C 235/84C07D 277/56A61K 31/215C07D 295/135A61P 3/06A61K 31/277C07C 237/42A61K 31/235A61P 9/00A61P 3/10A61K 31/40C07C 233/81A61K 31/4402C07C 235/34A61K 31/397C07C 235/14A61K 31/381C07C 69/88C07C 235/26C07C 311/04C07D 209/08C07D 263/58A61K 31/423A61P 3/04C07D 277/30C07C 2603/18C07D 295/192A61K 31/4418C07D 207/09
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References
Claims
Abstract

A novel therapeutic agent for hyperlipidemia, which is an ester compound represented by the formula (1″) (wherein R 1 and R 2 are each hydrogen atom or optionally substituted aryl, etc.; X is —COO— or —CON(R 10 )—; R 3 and R 4 are each hydrogen atom, C 1 -C 6 alkyl or C 1 -C 6 alkoxy, etc.; R 5 , R 6 and R 7 are each hydrogen atom, C 1 -C 6 alkyl or C 1 -C 6 alkoxy, etc.; R 9 and R 9 are each independently hydrogen atom, C 1 -C 6 alkyl, —CON(R 18 ) (R 19 ) or —COO(R 20 ), etc.; ring A, ring B and ring C are each independently aryl or heterocycle residue, etc.; Alk 1 and Alk 2 are each independently alkanediyl, etc.; l and m are each an integer of 0 or 1 to 3) or a prodrug thereof, or a pharmaceutically acceptable salt of either. The therapeutic agent selectively inhibits MTP in the small intestine, thus causes no such side effect as a fatty liver.
Claims

exact text as granted — not AI-modified
1 . An ester compound represented by the formula (1) 
       
         
           
           
               
               
           
         
       
       wherein
 R 1  and R 2  are each hydrogen, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, C 1 -C 6  alkoxy, halo C 1 -C 6  alkyl, halo C 1 -C 6  alkyloxy, optionally substituted C 6 -C 14  aryl, optionally substituted C 7 -C 16  aralkyl, optionally substituted C 6 -C 14  aryloxy, optionally substituted C 7 -C 16  aralkyloxy, optionally substituted C 7 -C 15  arylcarbonyl, optionally substituted heterocycle, C 2 -C 7  alkoxycarbonyl, halogen, C 2 -C 6  alkenyl, —N(R 40 )(R 41 ) wherein R 40′  and R 41  are each independently hydrogen or optionally substituted C 6 -C 14  aryl; 
 ring A is C 6 -C 14  aryl, heterocycle, or 
 
       
         
           
           
               
               
           
         
         X is —COO—(CH 2 ) n —, —CON)(R 10 )—(CH 2 ) n — or) —N(R 10 )—CO—(CH 2 ) n — wherein R 10  is hydrogen, C 1 -C 6  alkyl or C 3 -C 7  cycloalkyl and n is an integer of 0 to 3; 
         R 3  and R 4  are each independently hydrogen, hydroxy, halogen, optionally substituted C 1 -C 6  alkyl, C 1 -C 6  alkoxy, halo C 1 -C 6  alkyl, C 7 -C 16  aralkyloxy, C 1 -C 6  acyl, optionally substituted heterocycle, —CON(R 11 )(R 12 ) (wherein R 11  and R 12  are each independently hydrogen, C 1 -C 6  alkyl, optionally substituted C 6 -C 14  aryl, optionally substituted C 7 -C 16  aralkyl, C 1 -C 6 alkoxy, or R 11  and R 12  may be taken together with the nitrogen to which they are attached to form 
       
       
         
           
           
               
               
           
         
       
       , wherein p is an integer of 0 to 2), —(CH 2 ) q —N(R 13 )(R 14 ) (wherein R 13  and R 14  are each independently hydrogen, C 1 -C 6  alkyl, C 2 -C 7  alkoxycarbonyl, C 1 -C 6  acyl, or R 13  and R 14  may be taken together with the nitrogen to which they are attached to form 
       
         
           
           
               
               
           
         
       
       , wherein p has the same meaning as defined above and q is an integer of 0 to 3), or —CO(R 15 ) (wherein R 15  is hydroxy, C 1 -C 6  alkoxy, optionally substituted C 6 -C 14  aryloxy, optionally substituted C 7 -C 16  aralkyloxy or C 1 -C 6  alkyl);
 ring B is 
 
       
         
           
           
               
               
           
         
       
       , wherein K is an integer of 0 to 2, or ring B may be taken together with R 3 , R 10  and the nitrogen bound to R 10  to form 
       
         
           
           
               
               
           
         
       
       Alk1 1  is alkanediyl or alkenediyl;
 Alk1 2  is alkanediyl or alkenediyl; 
 1 is an integer of 0 to 3; 
 m is an integer of 0 to 3; 
 D is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 7  alkoxycarbonyl, —N(R 42 )—CO(R 43 ) (wherein R 42  is hydrogen or C 1 -C 6  alkyl and R 43  is C 6 -C 14  aryl or C 7 -C 16  aralkyl), or the group represented by the following formula 
 
       
         
           
           
               
               
           
         
       
       (wherein R 5 , R 6  and R 7  are each independently hydrogen, C 1 -C 6  alkyl, C 1 -C 6  alkoxy, C 2 -C 7  alkoxycarbonyl, carboxyl, halogen, cyano, nitro, halo C 1 -C 6  alkyl, C 1 -C 6  acyl, hydroxy, amino, optionally substituted C 6 -C 14  aryl, or —(CH 2 ) r —CON(R 16 )(R 17 ) (wherein R 16  and R 17  are each independently hydrogen, C 1 -C 6  alkyl or halo C 1 -C 6  alkyl and r is an integer of 0 to 3);
 ring C is C 6 -C 14  aryl, C 7 -C 15  arylcarbonylamino, C 6 -C 17  aralkylcarbonylamino, heterocycle residue, C 3 -C 7  cycloalkyl or C 7 -C 16  aralkyl, or ring C may be taken together with R 7  and R 8  to form 
 
       
         
           
           
               
               
           
         
       
       and
 R 8  and R 9  are each independently hydrogen, C 1 -C 6  alkyl, optionally substituted C 6 -C 14  aryl, hydroxy C 1 -C 6  alkyl, —CON(R 18 )(R 19 ) (wherein R 18  and R 19  are each independently hydrogen, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, halo C 1 -C 6  alkyl, C 2 -C 12  alkoxyalkyl or optionally substituted C 6 -C 14  aryl), —COO(R 20 ) or —(CH 2 ) s —OCO(R 20 ) (wherein R 20  is hydrogen, C 1 -C 6  alkyl or C 3 -C 7  cycloalkyl; s is an integer of 0 to 3), —N(R 21 )(R 22 ) (wherein R 21  and R 22  are each independently hydrogen, C 1 -C 6  alkyl, C 1 -C 6  acyl, C 1 -C 6  alkylsulfonyl, or R 21  and R 22  may be taken together with the nitrogen to which they are attached to form 
 
       
         
           
           
               
               
           
         
       
       or
 R 8  and R 9  may be taken together to form C 3 -C 7  cycloalkyl, or a prodrug thereof, or a pharmaceutically acceptable salt of either. 
 
     
     
         2 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 1 , wherein D is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 7  alkoxycarbonyl or —N(R 42 )—CO(R 43 ) in which R 42  and R 43  each has the same meaning as defined above. 
     
     
         3 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 1 , wherein D is the group represented by the formula 
       
         
           
           
               
               
           
         
       
       in which R 5 , R 6  and R 7  each has the same meaning as defined above. 
     
     
         4 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 3 , wherein the ring C is 
       
         
           
           
               
               
           
         
       
       in which q is an integer of 0 to 3. 
     
     
         5 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 2  or  claim 4 , wherein ring B is 
       
         
           
           
               
               
           
         
       
     
     
         6 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to according to  claim 5 , wherein ring A is 
       
         
           
           
               
               
           
         
       
     
     
         7 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 6 , wherein X is) —CON(R 10 )—(CH 2 ) n — in which R 10  and n each has the same meaning as defined above. 
     
     
         8 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 6 , wherein X is —COO—(CH 2 ) n — in which n has the same meaning as defined above; 
     
     
         9 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 7  or  claim 8 , wherein n is 0. 
     
     
         10 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 1 , which is represented by the formula (1′) 
       
         
           
           
               
               
           
         
       
       wherein
 R 2′  and R 2″  are each independently hydrogen, C 1 -C 6  alkyl, C 3 -C 7  cycloalkyl, C 1 -C 6  alkoxy, halogen, halo C 1 -C 6  alkyl, C 1 -C 6  acyl, C 2 -C 6  alkenyl or cyano; 
 X 1  is —O— or —NR 10 — wherein R 10  is hydrogen, C 1 -C 6  alkyl or C 3 -C 7  cycloalkyl; and 
 R 1 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9  ring C, 1 and m each has the same meaning as defined above, 
 
       or a prodrug thereof, or a pharmaceutically acceptable salt of either. 
     
     
         11 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 10 , wherein the ring C is 
       
         
           
           
               
               
           
         
       
       in which q is an integer of 0 to 3. 
     
     
         12 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 11 , wherein X 1  is —NR 10 — in which R 10  has the same meaning as defined above. 
     
     
         13 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 11 , wherein X 1  is —O—. 
     
     
         14 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claims 10  to  13 , wherein the group —(CH 2 ) 1 — is located at the h-position of the benzene ring in the formula (1′). 
     
     
         15 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claims 10  to  13 , wherein the group —(CH 2 ) 1 — is located at the i-position of the benzene ring in the formula (1′). 
     
     
         16 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claims 10  to  15 , wherein R 8  and R 9  are each independently —CON(R 18 )(R 19 )— in which R 18  and R 19  each has the same meaning as defined above. 
     
     
         17 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claims 10  to  15 , wherein R 8  and R 9  are each independently —COO(R 20 )— in which R 20  has the same meaning as defined above. 
     
     
         18 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claims 12  to  17 , wherein the ring C is C 6 -C 14  aryl. 
     
     
         19 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 18 , wherein C 6 -C 14  aryl is phenyl. 
     
     
         20 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claims 12  to  17 , wherein the ring C is C 3 -C 7  cycloalkyl. 
     
     
         21 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to claims  12  to  17 , wherein the ring C is 
       
         
           
           
               
               
           
         
       
     
     
         22 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 1 , which is selected from the group consisting of
 {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-phenyl-2-{2-[4-(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-malonic acid diethyl ester,   2-(2-{3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[methyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 9-(2,2,2-trifluoro-ethylcarbamoyl)-9H-fluoren-9-ylmethyl ester,   2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-propionic acid 9-(2,2,2-trifluoro-ethylcarbamoyl)-9H-fluoren-9-ylmethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 1-(2,2,2-trifluoro-ethylcarbamoyl)-cyclopentylmethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diisopropyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dimethyl ester,   2-cyclopentyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 1-(2,2,2-trifluoro-ethylcarbamoyl)-cyclohexylmethyl ester,   2-phenyl-2-{2-[4-(2-trifluoromethyl-benzoylamino)-phenyl]-acetoxymethyl}-malonic acid diethyl ester,   2-{2-[4-(2-phenoxy-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-{2-[4-(2-butoxy-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-{2-[4-(2-trifluoromethyl-benzoyloxy)-phenyl]-acetoxymethyl}-malonic acid diethyl ester,   2-{2-[4-(2-benzoyl-benzoyloxy)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-{2-[4-(2-benzoyl-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dicyclohexyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-cyclohexylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-phenylcarbamoyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-isopropylcarbamoyl-2-phenyl-ethyl ester,   2-benzyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{2-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-[2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethoxycarbonylmethyl]-phenyl ester,   biphenyl-2-carboxylic acid 4-[2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethoxycarbonylmethyl]-phenyl ester,   2-butoxy-benzoic acid 4-[2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethoxycarbonylmethyl]-phenyl ester,   2-cyclohexyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {4-[(biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   [4-(2-phenoxy-benzoylamino)-phenyl]-acetic acid 2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   2-phenyl-2-(2-{2-trifluoromethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-methylcarbamoyl-2-phenyl-ethyl ester,   2-pyridin-2-yl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-pyridin-3-yl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonylmethyl)-phenyl ester,   2-phenyl-2-(2-{3-trifluoromethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   [4-(2-butoxy-benzoylamino)-phenyl]-acetic acid 2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-butylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{4-[(9-oxo-9h-fluorene-1-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(9h-fluorene-1-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{4-[(4′-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-methoxy-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-phenyl-3,3-bis-propylcarbamoyl-propyl ester,   {4-[(biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   [4-(2-phenoxy-benzoylamino)-phenyl]-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   [4-(2-butoxy-benzoylamino)-phenyl]-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-phenyl-2-(2-{4-[(3′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{4-[2-(4-fluoro-benzoyl)-benzoylamino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonylmethyl)-2-chloro-phenyl ester,   2-phenyl-2-{2-[4-(2-thiophen-3-yl-benzoylamino)-phenyl]-acetoxymethyl}-malonic acid diethyl ester,   2-(2-{4-[(biphenyl-3-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[isopropyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[cyclohexyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[4-(2-isopropyl-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-{2-[4-(2-benzyl-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dipropyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diisobutyl ester,   2-phenyl-2-{2-[4-(2-trifluoromethoxy-benzoylamino)-phenyl]-acetoxymethyl}-malonic acid diethyl ester,   2-{2-[4-(2-butoxycarbonyl-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-isobutylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-(3-methyl-butylcarbamoyl)-2-phenyl-ethyl ester,   2-(2-{4-[ethyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   [4-(2-cyclohexyl-benzoylamino)-phenyl]-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-chloro-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {4-[(3′,4′-dichloro-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-(2-methoxy-ethylcarbamoyl)-2-phenyl-ethyl ester,   2-[2-(4-{[2-methyl-4-(4-trifluoromethyl-phenyl)-thiazole-5-carbonyl]-amino}-phenyl)-acetoxymethyl]-2-phenyl-malonic acid diethyl ester,   (4-{[2-methyl-4-(4-trifluoromethyl-phenyl)-thiazole-5-carbonyl]-amino}-phenyl)-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   (4-{[2-(4-trifluoromethyl-phenyl)-pyridine-3-carbonyl]-amino}-phenyl)-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   (3-methyl-4-{[2-(4-trifluoromethyl-phenyl)-pyridine-3-carbonyl]-amino}-phenyl)-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-isopropyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-isopropyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-isobutyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-isobutyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-chloro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {3-methylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-benzylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 4,4-bis-ethylcarbamoyl-4-phenyl-butyl ester,   {3-diethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-diisopropylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-diethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-diisopropylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-(isopropyl-methyl-carbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-(ethyl-methyl-carbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-(ethyl-methyl-carbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(ethyl-methyl-carbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-(piperidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(pyrrolidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(pyrrolidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(methyl-propyl-carbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(methyl-propyl-carbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-ethylcarbamoyl-2-phenyl-ethyl ester,   2-phenyl-2-(2-{3-(pyrrolidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{3-(piperidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2-propionylamino-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2-propionylamino-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-(2,5-dioxo-pyrrolidin-1-yl)-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-ethylcarbamoyl-benzyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-ethylcarbamoylmethyl-benzyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-isopropylamino-2-phenyl-ethyl ester hydrochloride,   [3-dimethylcarbamoyl-4-(2-trifluoromethyl-benzoylamino)-phenyl]-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-{2-[3-dimethylcarbamoyl-4-(2-trifluoromethyl-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-fluoro-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-bromo-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-acetylamino-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-butyrylamino-2-phenyl-ethyl ester,   [4-(2-benzoyl-benzoylamino)-3-dimethylcarbamoyl-phenyl]-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-{2-[4-(2-benzoyl-benzoylamino)-3-dimethylcarbamoyl-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid dimethyl ester,   2-cyclopentyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy methyl)-malonic acid diethyl ester,   2-cyclohexyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy methyl)-malonic acid diethyl ester,   2-(2-{4-[(4′-chloro-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-acetyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   [3-dimethylcarbamoyl-4-(2-phenoxy-benzoylamino)-phenyl]-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-{2-[3-dimethylcarbamoyl-4-(2-phenoxy-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-cyano-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-methanesulfonylamino-2-phenyl-ethyl ester,   3-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-2-phenyl-propionic acid ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-(methyl-propionyl-amino)-2-phenyl-ethyl ester,   2-[3-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-propyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-methoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(5-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(6-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester),   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid di-2,2,2-trifluoroethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(2′-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino[-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-5-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-chloro-5-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(3′-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(3′-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(5-nitro-pyridin-2-yl)-malonic acid diethyl ester,   2-(5-amino-pyridin-2-yl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-pyridin-2-yl-malonic acid diethyl ester,   2-(2-{3-chloro-5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-o-tolyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-m-tolyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-p-tolyl-malonic acid diethyl ester,   2-(2-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(3-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(4-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-succinic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(2-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(3-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(4-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{4-[(5,4′-bis-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(6-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(6-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{3-dimethylcarbamoyl-4-[(5-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-ethoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-isopropoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{4-[(5,4′-bis-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(6-methoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(3-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[4-(2,4-bis-trifluoromethyl-benzoylamino)-3-dimethylcarbamoyl-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-ethyl-4-trifluoromethyl-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-ethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-isopropenyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-isopropyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[3-dimethylcarbamoyl-4-(2-isopropenyl-4-trifluoromethyl-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-{2-[3-dimethylcarbamoyl-4-(2-isopropyl-4-trifluoromethyl-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[2-(3-trifluoromethyl-phenylamino)-benzoylamino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[3-dimethylcarbamoyl-4-(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[2-(3-trifluoromethyl-phenoxy)-benzoylamino]-phenyl}-acetoxymethyl)-1-2-phenyl-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-ethyl-2-phenyl-butyl ester,   2-(2-{3-dimethylcarbamoyl-4-[2-(4-trifluoromethyl-phenoxy)-benzoylamino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 1-phenyl-cyclopropylmethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-diphenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 1-phenyl-cyclopentylmethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-hydroxy-2-hydroxymethyl-2-phenyl-propyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-acetoxy-2-acetoxymethyl-2-phenyl-propyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-thiophen-2-yl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-thiophen-3-yl-malonic acid diethyl ester,   2-(2-{4-dimethylcarbamoyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-pyridin-2-yl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(3-methyl-thiophen-2-yl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(5-methyl-thiophen-2-yl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-thiazol-2-yl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-isopropyl-malonic acid diethyl ester,   2-sec-butyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-isobutyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-propyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-ethyl-malonic acid diethyl ester,   2-butyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-allyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   3-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-2,2-bis-ethoxycarbonyl-propionic acid ethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(1-methyl-butyl)-malonic acid diethyl ester,   2-(2-{3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-hydroxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   2-(2-{3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-propoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-benzyloxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-benzyloxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-hydroxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[3-methoxy-4-(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   {3-dimethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-piperidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-pyrrolidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-phenyl-2-(2-{3-piperidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{3-pyrrolidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-morpholin-4-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-diethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-[2-(2-{3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-malonic acid diethyl ester,   {3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-phenyl-3,3-bis-propylcarbamoyl-propyl ester,   2-[2-(2-{4-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-methyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   {3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-isopropylcarbamoyl-3-phenyl-propyl ester,   {2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3, 3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 4,4-bis-ethylcarbamoyl-4-phenyl-butyl ester,   {2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-phenyl-3,3-bis-propylcarbamoyl-propyl ester,   {2-methoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   2-[2-(2-{2-methoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   {2-ethoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   2-[2-(2-{2-ethoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-isopropoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-methoxycarbonyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-ethoxy-5-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 2-[9-(2,2,2-trifluoro-ethylcarbamoyl)-9h-fluoren-9-yl]-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 2-(9h-fluoren-9-yl)-ethyl ester,   n-biphenyl-2-yl-terephthalamic acid 2-[9-(2,2,2-trifluoro-ethylcarbamoyl)-9h-fluoren-9-yl]-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 2-[(biphenyl-2-carbonyl)-amino]-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 2-(2-biphenyl-2-yl-acetylamino)-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-naphthalen-1-yl-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-[2-(2,2,2-trifluoro-ethylcarbamoyl)-naphthalen-1-yl]-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3,3-diphenyl-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-biphenyl-2-yl-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-phenyl-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 2-[8-(2,2,2-trifluoro-ethylcarbamoyl)-naphthalen-1-yl]-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-(2,6-dichloro-phenyl)-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-(2-chloro-phenyl)-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoyloxy}-ethyl)-malonic acid diethyl ester,   2-(2-{3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoyloxy}-ethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{2-chloro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoyloxy}-ethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-{2-[4-(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-benzoyloxy]-ethyl}-malonic acid diethyl ester,   2-{2-[4-(2-benzoyl-benzoyloxy)-benzoyloxy]-ethyl}-2-phenyl-malonic acid diethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonyl)-2-chloro-phenyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonyl)-phenyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonyl)-2,6-dichloro-phenyl ester,   4-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-cyclohexanecarboxylic acid 2-[9-(2,2,2-trifluoro-ethylcarbamoyl)-9h-fluoren-9-yl]-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-cyclohexanecarboxylic acid 2-[9-(2,2,2-trifluoro-ethylcarbamoyl)-9h-fluoren-9-yl]-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-cyclohexanecarboxylic acid 3-phenyl-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   2-phenyl-2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-cyclohexanecarbonyloxymethyl}-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-cyclohexanecarbonyloxy}-ethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-indol-1-yl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{2-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoimidazol-1-yl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   [2-oxo-3-(4′-trifluoromethyl-biphenyl-2-carbonyl)-2,3-dihydro-benzooxazol-6-yl]-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-ethoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(3-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-propionyloxymethyl)-2-phenyl-malonic acid diethyl ester,   4-{[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-methyl}-benzoic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   3-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-propionic acid ethylcarbamoyl-phenyl-methyl ester,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid benzyl ester,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid ethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoimidazol-1-yl}-acetoxymethyl)-malonic acid diethyl ester,   3-{[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-methyl}-benzoic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid methyl ester,   2-(2-{3-benzyloxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-carboxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[2-oxo-3-(4′-trifluoromethyl-biphenyl-2-carbonyl)-2,3-dihydro-benzooxazol-6-yl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-{2-[8-oxo-7-(4′-trifluoromethyl-biphenyl-2-carbonyl)-7-aza-bicyclo[4.2.0]octa-1(6),2,4-trien-3-yl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isopropoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-methoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(3-dimethylcarbamoyl-4-{[1-(2-nitrol-4-trifluoro-methyl-phenyl)-pyrrolidine-2-carbonyl]-amino}-phenyl)-acetoxymethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-acetylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-methoxycarbonylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-(4-methyl-thiazol-2-yl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{6-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-biphenyl-3-yl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-formyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylaminomethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-(methoxy-methyl-carbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isobutyryl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester, and   2-(2-{3-(1-hydroxy-2-methyl-propyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester.   
     
     
         23 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 1 , which is selected from the group consisting of
 4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-phenyl-2-{2-[4-[(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-malonic acid diethyl ester,   2-(2-{3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[methyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 9-(2,2,2-trifluoro-ethylcarbamoyl)-9h-fluoren-9-ylmethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-propionic acid 9-(2,2,2-trifluoro-ethylcarbamoyl)-9h-fluoren-9-ylmethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   2-phenyl-2-(2-{4-[4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diisopropyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dimethyl ester,   2-cyclopentyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dicyclohexyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-cyclohexylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-phenylcarbamoyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-isopropylcarbamoyl-2-phenyl-ethyl ester,   2-benzyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl-malonic acid diethyl ester,   2-(2-{2-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl-2-phenyl-malonic acid diethyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-[2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethoxycarbonylmethyl]-phenyl ester,   biphenyl-2-carboxylic acid 4-[2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethoxycarbonylmethyl]-phenyl ester,   2-cyclohexyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {4-[(biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   2-phenyl-2-(2-{2-trifluoromethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-methylcarbamoyl-p-phenyl-ethyl ester,   2-pyridin-2-yl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl-malonic acid diethyl ester,   2-pyridin-3-yl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonylmethyl)-phenyl ester,   2-phenyl-2-(2-{3-trifluoromethyl-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-butylcarbamoyl-2-phenyl-ethyl ester,   {3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{4-[(4′-methyl-biphenyl-2-carbonyl}-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-methoxy-biphenyl-2-carbonyl}-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl}-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl}-amino]-phenyl}-acetic acid 3-phenyl-3,3-bis-propylcarbamoyl-propyl ester,   {4-[(biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-phenyl-2-(2-{4-[(3′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonylmethyl)-2-chloro-phenyl ester,   2-(2-{4-[isopropyl-(4′-trifluoromethyl-biphenyl-2-carbonyl}-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[cyclohexyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dipropyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diisobutyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl}-amino]-phenyl}-acetic acid 2,2-bis-isobutylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl}-amino]-phenyl}-acetic acid 2,2-bis-(3-methyl-butylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{4-[ethyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {4-[(4′-chloro-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-(ethylcarbamoyl-2-phenyl-ethyl ester,   {4-[(3′,4′-dichloro-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-(ethylcarbamoyl-2-phenyl-ethyl ester,   {3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl}-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl}-amino]-phenyl}-acetic acid 2,2-bis-(2-methoxy-ethylcarbamoyl)-2-phenyl-ethyl ester,   2-(2-{3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl}-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-isopropyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl}-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-isopropyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-isobutyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-isobutyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-chloro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {3-methylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-ethyl ester,   2-(2-{3-diethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-benzylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 4,4′-bis-ethylcarbamoyl-4-phenyl-butyl ester,   {3-diethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-diisopropylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-diethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-diisopropylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-(isopropyl-methylcarbamoyl)-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-(ethyl-methylcarbamoyl)-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-(ethyl-methylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(ethyl-methylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-(piperidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(pyrrolidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(methyl-propylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(methyl-propylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-ethyl ester,   {3-(dimethylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-ethyl-carbamoyl-2-phenyl-ethyl ester,   2-phenyl-2-(2-{3-(pyrrolidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{3-(piperidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2-propionylamino-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2-propionylamino-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-(2,5-dioxo-pyrrolidin-1-yl)-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-ethylcarbamoyl-benzyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl}-amino]-phenyl}-acetic acid 2-ethylcarbamoylmethyl-benzyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-isopropylamino-2-phenyl-ethyl ester hydrochloride,   2-[2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-fluoro-biphenyl-2-carbonyl}-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-bromo-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-acetylamino-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-butyrylamino-2-phenyl-ethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid dimethyl ester,   2-cyclopentyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-cyclohexyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{4-[(4′-chloro-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-acetyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-cyano-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-methanesulfonylamino-2-phenyl-ethyl ester,   3-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-2-phenyl-propionic acid ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-(methyl-propionyl-amino)-2-phenyl-ethyl ester,   2-[3-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-propyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-methoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[5-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(6-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid di-2,2,2-trifluoroethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(2′-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-5-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-chloro-5-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(3′-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-(3′-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(5-nitro-pyridin-2-yl)-malonic acid diethyl ester,   2-(5-amino-pyridin-2-yl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-pyridin-2-yl-malonic acid diethyl ester,   2-(2-{3-chloro-5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-o-tolyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-m-tolyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-p-tolyl-malonic acid diethyl ester,   2-(2-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(3-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(4-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-succinic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(2-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(3-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(4-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{4-(5,4′-bis-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl}-malonic acid diethyl ester,   2-(2-{4-(6-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(6-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{3-dimethylcarbamoyl-4-[(5-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-ethoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-isopropoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{4-[(5,4′-bis-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(6-methoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(3-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[4-(2,4-bis-trifluoromethyl-benzoylamino)-3-dimethylcarbamoyl-phenyl]-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[3-dimethylcarbamoyl-4-(2-ethyl-4-trifluoromethyl-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-ethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-isopropenyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-isopropyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-ethyl-2-phenyl-butyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 1-phenyl-cyclopropylmethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-diphenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 1-phenyl-cyclopentylmethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-hydroxy-2-hydroxymethyl-2-phenyl-propyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-acetoxy-2-acetoxymethyl-2-phenyl-propyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-thiophen-2-yl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-thiophen-3-yl-malonic acid diethyl ester,   2-(2-{4-dimethylcarbamoyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-pyridin-2-yl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(3-methyl-thiophen-2-yl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(5-methyl-thiophen-2-yl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-thiazol-2-yl-malonic acid diethyl ester,   2-(2-{3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-hydroxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   2-(2-{3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-propoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-benzyloxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-benzyloxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-hydroxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   {3-dimethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-piperidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-pyrrolidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-phenyl-2-(2-{3-piperidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{3-pyrrolidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   (2-{3-morpholin-4-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-diethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(2-(2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-[2-(2-{3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-malonic acid diethyl ester,   {3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-phenyl-3,3-bis-propylcarbamoyl-propyl ester,   2-[2-(2-{4-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy-ethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-methyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   {3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-isopropylcarbamoyl-3-phenyl-propyl ester,   {2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 4,4-bis-ethylcarbamoyl-4-phenyl-butyl ester,   {2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-phenyl-3,3-bis-propylcarbamoyl-propyl ester,   {2-methoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   2-[2-(2-{2-methoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   {2-ethoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   2-[2-(2-{2-ethoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-isopropoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-methoxycarbonyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-ethoxy-5-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 2-[9-(2,2,2-trifluoro-ethylcarbamoyl)-9h-fluoren-9-yl]-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 2-[9h-fluoren-9-yl]-ethyl ester,   n-biphenyl-2-yl-terephthalamic acid 2-[9-(2,2,2-trifluoro-ethylcarbamoyl)-9h-fluoren-9-yl]-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 2-[(biphenyl-2-carbonyl)-amino]-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 2-(2-biphenyl-2-yl-acetylamino)-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-naphthalen-1-yl-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-[2-(2,2,2-trifluoro-ethylcarbamoyl)-naphthalen-1-yl]-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3,3-diphenyl-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-biphenyl-2-yl-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-phenyl-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 2-[8-(2,2,2-trifluoro-ethylcarbamoyl)-naphthalen-1-yl]-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-[(2,6-dichloro-phenyl)-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-(2-chloro-phenyl)-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoyloxy}-ethyl)-malonic acid diethyl ester,   2-(2-{3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoyloxy}-ethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{2-chloro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoyloxy}-ethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-{2-[4-[(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-benzoyloxy]-ethyl}-malonic acid diethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbony)-2-chloro-phenyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonyl)-phenyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonyl)-2,6-dichloro-phenyl ester,   2-(2-{3-ethoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(3-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-propionyloxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-propionic acid ethylcarbamoyl-phenyl-methyl ester,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid benzyl ester,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid ethyl ester,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid methyl ester,   2-(2-{3-benzyloxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-carboxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isopropoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-methoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-acetylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-methoxycarbonylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-(4-methyl-thiazol-2-yl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{6-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-biphenyl-3-yl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-formyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylaminomethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-3-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-methoxy-methylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-3-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isobutyryl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-3-acetoxymethyl)-2-phenyl-malonic acid diethyl ester, and   2-(2-{3-(1-hydroxy-2-methyl-propyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester.   
     
     
         24 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 1 , which is selected from the group consisting of
 {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl)-2-phenyl-ethyl ester,   2-phenyl-2-{2-[4-[(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-malonic acid diethyl ester,   2-(2-{3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[methyl-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-2-phenyl]-acetic acid 2,2-bis-ethylcarbamoyl-phenyl-ethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl) -amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diisopropyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dimethyl ester,   2-cyclopentyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dicyclohexyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-cyclohexylcarbamoyl-2-phenyl ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-phenylcarbamoyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-isopropylcarbamoyl-2-phenyl-ethyl ester,   2-benzyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{2-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-[2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethoxycarbonylmethyl]-phenyl ester,   biphenyl-2-carboxylic acid 4-[2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethoxycarbonylmethyl]-phenyl ester,   2-cyclohexyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {4-[(biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   2-phenyl-2-(2-{2-trifluoromethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-methylcarbamoyl-2-phenyl-ethyl ester,   2-pyridin-2-yl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-pyridin-3-yl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(2,2-bis-ethylcarbamoyl)-2-phenyl-ethoxycarbonylmethyl)-phenyl ester,   2-phenyl-2-(2-{3-trifluoromethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-butylcarbamoyl-2-phenyl-ethyl ester,   {3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{4-[(4′-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-methoxy-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-phenyl-3,3-bis-propylcarbamoyl-propyl ester,   {4-[(biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-phenyl-2-(2-{4-[(3′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(2,2-bis-ethylcarbamoyl)-2-phenyl-ethoxycarbonylmethyl)-2-chloro-phenyl ester,   2-(2-{4-[isopropyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[cyclohexyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dipropyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diisobutyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-isobutylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-(3-methyl-butylcarbamoyl)-2-phenyl-ethyl ester,   2-(2-{4-[ethyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {4-[(4′-chloro-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {4-[(3′4′-dichloro-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-(2-methoxy-ethylcarbamoyl)-2-phenyl-ethyl ester,   2-(2-{3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic   acid diethyl ester,   {3-isopropyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-isopropyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-isobutyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-isobutyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-chloro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {3-methylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   2-(2-{3-diethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-benzylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 4,4-bis-ethylcarbamoyl-4-phenyl-butyl ester,   {3-diethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-diisopropylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-diethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-diisopropylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-(isopropyl-methylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-(ethyl-methylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-(ethyl-methylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(ethyl-methylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-(piperidin-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(pyrrolidin-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(methyl-propylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(methyl-propylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-ethylcarbamoyl-2-phenyl-ethyl ester,   2-phenyl-2-(2-{3-pyrrolidin-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{3-piperidin-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2-propionylamino-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-(2,5-dioxo-pyrrolidin-1-yl)-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-ethylcarbamoyl-benzyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-ethylcarbamoylmethyl-benzyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-isopropylamino-2-phenyl-ethyl ester hydrochloride,   2-[2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-fluoro-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-bromo-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-acethylamino-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-butyrylamino-2-phenyl-ethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid dimethyl ester,   2-cyclopentyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-cyclohexyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{4-[(4′-chloro-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-acetyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-cyano-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4-methyl-4′-trifluromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-methyl-4′-trifluromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-methanesulfonylamino-2-phenyl-ethyl ester,   3-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-2-phenyl-propionic acid ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-(methyl-propionyl-amino)-2-phenyl-ethyl ester,   2-[3-(2-{3-dimethylcarbamoyl-4-[(4′-trifluromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-propyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-methoxy-4′-trifluromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(5-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(6-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid di-2,2,2-trifluoroethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(2′-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-5-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-chloro-5-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(3′-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(3′-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(5-nitro-pyridin-2-yl)-malonic acid diethyl ester,   2-(5-amino-pyridin-2-yl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-pyridin-2-yl-malonic acid diethyl ester,   2-(2-{3-chloro-5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-o-tolyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-m-tolyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-p-tolyl-malonic acid diethyl ester,   2-(2-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(3-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(4-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-succinic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(2-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(3-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(4-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{4-[(5,4′-bis-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(6-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(6-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{3-dimethylcarbamoyl-4-[(5-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-ethoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-isopropoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{4-(5,4′-bis-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-(6-methoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(3-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[4-(2,4-bis-trifluoromethyl-benzoylamino)-3-dimethylcarbamoyl-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[3-dimethylcarbamoyl-4-[(2-ethyl-4-trifluoromethyl-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-ethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-isopropenyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-isopropyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-ethyl-2-phenyl-butyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 1-phenyl-cyclopropylmethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-diphenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 1-phenyl-cyclopentylmethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-hydroxy-2-hydroxymethyl-2-phenyl-propyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-acetoxymethyl-2-phenyl-propyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl]-2-thiophen-2-yl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl]-2-thiophen-3-yl-malonic acid diethyl ester,   2-(2-{4-dimethylcarbamoyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-pyridin-2-yl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl]-2-(3-methyl-thiophen-2-yl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(5-methyl-thiophen-2-yl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-thiazol-2-yl-malonic acid diethyl ester,   2-(2-{3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-hydroxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester   2-(2-{3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   2-(2-{3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-propoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-benzyloxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-(2-{3-benzyloxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-hydroxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[3-methoxy-4-(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   {3-dimethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-piperidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-pyrrolidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-phenyl-2-(2-{3-piperidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{3-pyrrolidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-morpholin-4-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-diethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-[2-(2-{3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-malonic acid diethyl ester,   {3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-phenyl-3,3-bis-propylcarbamoyl-propyl ester,   2-[2-(2-{4-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-methyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   {3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-isopropylcarbamoyl-3-phenyl-propyl ester,   {2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 4,4-bis-ethylcarbamoyl-4-phenyl-butyl ester,   {2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-phenyl-3,3-bis-propylcarbamoyl-propyl ester,   {2-methoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   2-[2-(2-{2-methoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   {2-ethoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   2-[2-(2-{2-ethoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-isopropoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-methoxycarbonyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-ethoxy-5-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 2-[(biphenyl-2-carbonyl)-amino]-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 2-(2-biphenyl-2-yl-acetylamino)-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-naphthalen-1-yl-3-(2,2,2-trifluoroethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-[2-(2,2,2-trifluoro-ethylcarbamoyl)-naphthalen-1-yl]-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3,3-diphenyl-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-biphenyl-2-yl-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-phenyl-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 2-[8-(2,2,2-trifluoro-ethylcarbamoyl)-naphthalen-1-yl]-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-(2,6-dichloro-phenyl)-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-(2-chloro-phenyl)-3-(2,2,2-trifluoro-ethylcarbamoyl)-propyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoyloxy}-ethyl)-malonic acid diethyl ester,   2-(2-{3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoyloxy}-ethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{2-chloro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoyloxy}-ethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-{2-[4-(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-benzoyloxy]-ethyl}-malonic acid diethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonyl)-2-chloro-phenyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonyl)-phenyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonyl)-2,6-dichloro-phenyl ester,   2-(2-{3-ethoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(3-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-propionyloxymethyl)-2-phenyl-malonic acid diethyl ester,   3-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-propionic acid ethylcarbamoyl-phenyl-methyl ester,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid benzyl ester,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid ethyl ester,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid methyl ester,   2-(2-{3-benzyloxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-carboxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isopropoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-methoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-acetylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-methoxycarbonylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-(4-methyl-thiazol-2-yl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-(2-{6-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-biphenyl-3-yl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-formyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylaminomethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-(methoxy-methylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-(3-isobutyryl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester, and   2-(2-{3-(1-hydroxy-2-methyl-propyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester.   
     
     
         25 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 1 , which is selected from the group consisting of
 {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-cyclohexylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-phenylcarbamoyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-isopropylcaramoyl-2-phenyl-ethyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-[2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethoxycarbonylmethyl]-phenyl ester,   biphenyl-2-carboxylic acid 4-[2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethoxycarbonylmethyl]-phenyl ester,   {4-[(biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   2-phenyl-2-(2-{2-trifluoromethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-methylcarbamoyl-2-phenyl-ethyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonylmethyl)-phenyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-butylcarbamoyl-2-phenyl-ethyl-ester,   {3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-phenyl-3,3-bis-propylcarbamoyl-propyl ester,   {4-[(biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl ethyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonylmethyl)-2-chloro-phenyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-isobutylcarbamoyl-2-phenyl ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-(3-methyl-butylcarbamoyl)-2-phenyl ethyl ester,   {4-[(4′-chloro-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl ethyl ester,   {4-[(3′,4′-dichloro-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl)-2-phenyl-ethyl ester,   {3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl)-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-(2-methoxy-ethylcarbamoyl)-2-phenyl-ethyl ester,   {3-isopropyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-phenyl-ethyl ester,   {3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-isobutyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {3-methylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-benzylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 4,4-bis-ethylcarbamoyl-4-phenyl-butyl ester,   {3-diethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-diisopropylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(isopropyl-methylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(ethyl-methylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(ethyl-methylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-(piperidin-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(pyrrolidin-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(methyl-propylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(methyl-propylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-hydroxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid, 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-propoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-benzyloxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-piperidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-pyrrolidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-phenyl-3,3-bis-propylcarbamoyl-propyl ester,   {3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-isopropylcarbamoyl-3-phenyl-propyl ester,   {2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 4,4-bis-ethylcarbamoyl-4-phenyl-butyl ester,   {2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-phenyl-3,3-bis-propylcarbamoyl-propyl ester,   {2-methoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {2-ethoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonyl)-2-chloro-phenyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonyl)-phenyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonyl)-2,6-dichloro-phenyl ester,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid benzyl ester,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid ethyl ester, and   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid methyl ester.   
     
     
         26 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 1 , which is selected from the group consisting of
 2-phenyl-2-{2-[4-(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-malonic acid diethyl ester,   2-(2-{3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[methyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl) -amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diisopropyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dimethyl ester,   2-cyclopentyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dicyclohexyl ester,   2-benzyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{2-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-cyclohexyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{2-trifluoromethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-pyridin-2-yl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-pyridin-3-yl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{3-trifluoromethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{4-[(4′-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-methoxy-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(3′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{4-[isopropyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[cyclohexyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dipropyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diisobutyl ester,   2-(2-{4-[ethyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isopropyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isobutyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-chloro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-diethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-diisopropylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-(ethyl-methylcarbamoyl)-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-(pyrrolidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-phenyl-2-(2-{3-(pyrrolidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{3-(piperidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-[2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-bromo-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-cyclopentyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-cyclohexyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{4-[(4′-chloro-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-acetyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-cyano-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[3-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-propyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-methoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(5-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(6-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid di-2,2,2-trifluoroethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(2′-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-5-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-chloro-5-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(3′-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(3′-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(5-nitro-pyridin-2-yl)-malonic acid diethyl ester,   2-(5-amino-pyridin-2-yl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-pyridin-2-yl-malonic acid diethyl ester,   2-(2-{3-chloro-5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-o-tolyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-m-tolyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-p-tolyl-malonic acid diethyl ester,   2-(3-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(3-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(4-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-succinic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(2-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(3-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(4-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{4-[(5,4′-bis-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(6-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(6-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl)-malonic acid diethyl ester,   2-[2-(2-{3-dimethylcarbamoyl-4-[(5-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-ethoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-isopropoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl)-malonic acid diethyl ester,   2-[2-(2-{4-[(5,4′-bis-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(6-methoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(3-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[4-(2,4-bis-trifluoromethyl-benzoylamino)-3-dimethylcarbamoyl-phenyl]-acetoxymethyl}-2-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[3-dimethylcarbamoyl-4-[(2-ethyl-4-trifluoro-methyl-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-ethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-isopropenyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-isopropyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-thiophen-2-yl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-thiophen-3-yl-malonic acid diethyl ester,   2-(2-{4-dimethylcarbamoyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-pyridin-2-yl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(3-methyl-thiophen-2-yl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(5-methyl-thiophen-2-yl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-thiazol-2-yl-malonic acid diethyl ester,   2-(2-{3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-benzyloxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-hydroxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{3-piperidin-1-yl-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{3-pyrrolidin-1-yl-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-morpholin-4-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-diethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-[2-(2-{3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-malonic acid diethyl ester,   2-[2-(2-{4-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-methyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-methoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-ethoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-isopropoxy-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-methoxycarbonyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{2-ethoxy-5-methyl-3-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoyloxy}-ethyl]-malonic acid diethyl ester,   2-(2-{3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoyloxy}-ethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{2-chloro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoyloxy}-ethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-{2-[4-(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-benzoyloxy]-ethyl}-malonic acid diethyl ester,   2-(2-{3-ethoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(3-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-propionyloxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-benzyloxycarbony-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-carboxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isopropoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-methoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-acetylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-methoxycarbonylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-(4-methyl-thiazol-2-yl)-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{6-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-biphenyl-3-yl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-formyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylaminomethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-(methoxy-methylcarbamoyl)-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isobutyryl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester, and   2-(2-{3-(1-hydroxy-2-methyl-propyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester.   
     
     
         27 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 1 , which is selected from the group consisting of
 {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-cyclohexylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-phenylcarbamoyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-isopropylcarbamoyl-2-phenyl-ethyl ester,   {4-[(biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethyl ester,   2-phenyl-2-(2-{2-trifluoromethyl-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-methylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-butylcarbamoyl-2-phenyl-ethyl ester,   {3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethyl-carbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl-ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3-phenyl-3,3-bis-propyl-carbamoyl-propyl ester,   {4-[(biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-isobutylcarbamoyl-2-phenyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-(3-methyl-butylcarbamoyl)-2-phenyl-ethyl ester,   {4-[(4′-chloro-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   (4-[(3′,4′-dichloro-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-(2-methoxy-ethylcarbamoyl)-2-phenyl-ethyl ester,   {3-isopropyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-ethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethyl-carbamoyl-3-phenyl-propyl ester,   {3-isobutyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethyl-carbamoyl-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {3-methylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-benzylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 4,4-bis-ethylcarbamoyl-4-phenyl-butyl ester,   {3-diethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   |3-diisopropylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(isopropyl-methylcarbamoyl-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(ethyl-methylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-(piperidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(pyrrolidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(methyl-propylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(methyl-propylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   (3-hydroxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2-phenyl-2,2-bis-propylcarbamoyl-ethyl ester,   {3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   {3-propoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-benzyloxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-dimethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-piperidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-pyrrolidin-1-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3,3-bis-ethylcarbamoyl-3-phenyl-propyl ester,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino)-benzoic acid benzyl ester,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid,   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid ethyl ester, and   5-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonyl-methyl)-2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid methyl ester.   
     
     
         28 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 1 , which is selected from the group consisting of
 2-(2-{3-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[methyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diisopropyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dimethyl ester,   2-cyclopentyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dicyclohexyl ester,   2-benzyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{2-methyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-cyclohexyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{2-trifluoromethyl-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-pyridin-2-yl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-pyridin-3-yl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{3-trifluoromethyl-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{4-[(4′-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-methoxy-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(3′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{4-[isopropyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[cyclohexyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid dipropyl ester,   2-phenyl-2-(2-{4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diisobutyl ester,   2-(2-{4-[ethyl-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-ethyl-4-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isopropyl-4-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isobutyl-4-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-chloro-4-(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-diethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-diisopropylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-(ethyl-methylcarbamoyl)-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   {3-(ethyl-methylcarbamoyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   {3-(pyrrolidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetic acid 2,2-bis-ethylcarbamoyl-2-phenyl-ethyl ester,   2-phenyl-2-(2-{3-(pyrrolidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{3-(piperidine-1-carbonyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-[2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-fluoro-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-bromo-biphenyl-2-carbonyl)-amino]}-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid dimethyl ester,   2-cyclopentyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-cyclohexyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{4-[(4′-chloro-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-acetyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(4′-cyano-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4-methyl-4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-methyl-4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[3-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-propyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-methoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(5-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(6-methyl-4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid 2,2,2-trifluoroethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(2′-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-5-dimethylcarbamoyl-4-[(2′-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-chloro-5-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(3′-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(3′-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(5-nitro-pyridin-2-yl)-malonic acid diethyl ester,   2-(5-amino-pyridin-2-yl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-pyridin-2-yl-malonic acid diethyl ester,   2-(2-{3-chloro-5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-bromo-5-dimethylcarbamoyl-2-fluoro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-o-tolyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-m-tolyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-p-tolyl-malonic acid diethyl ester,   2-(2-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(3-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(4-chloro-phenyl)-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-succinic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(2-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(3-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(4-methoxy-phenyl)-malonic acid diethyl ester,   2-(2-{4-[(5,4′-bis-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{4-[(6-chloro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(6-fluoro-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{3-dimethylcarbamoyl-4-[(5-methyl-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-ethyl]-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-ethoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(5-isopropoxy-4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-[2-(2-{4-(5,4′-bis-trifluoromethyl-biphenyl-2-carbonyl)-amino]-3-dimethylcarbamoyl-phenyl}-acetoxy)-ethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-(6-methoxy-4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-(3-methyl-4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-(4-(2,4-bis-trifluoromethyl-benzoylamino)-3-dimethylcarbamoyl-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-{2-[3-dimethylcarbamoyl-4-(2-ethyl-4-trifluoro-methyl-benzoylamino)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-ethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-isopropenyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-isopropyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-thiophen-2-yl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-thiophen-3-yl-malonic acid diethyl ester,   2-(2-{4-dimethylcarbamoyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-pyridin-2-yl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(3-methyl-thiophen-2-yl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(5-methyl-thiophen-2-yl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-thiazol-2-yl-malonic acid diethyl ester,   2-(2-{3-ethoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-methoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isopropoxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-benzyloxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-hydroxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{3-piperidin-1-yl-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-phenyl-2-(2-{3-pyrrolidin-1-yl-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-morpholin-4-yl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-diethylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{2-chloro-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoyloxy}-ethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-ethoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(3-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-propionyloxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-benzyloxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-carboxy-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isopropoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-methoxycarbonyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-acetylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-methoxycarbonylamino-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-(4-methyl-thiazol-2-yl)-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-phenyl-2-(2-{6-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-biphenyl-3-yl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-formyl-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-dimethylaminomethyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-(methoxy-methylcarbamoyl)-4-[(4′-trifluoro-methyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester,   2-(2-{3-isobutyryl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester, and   2-(2-{3-(1-hydroxy-2-methyl-propyl)-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-phenyl-malonic acid diethyl ester.   
     
     
         29 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 1 , which is selected from the group consisting of
 4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-[2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethoxycarbonylmethyl]-phenyl ester,   biphenyl-2-carboxylic acid 4-[2-phenyl-2,2-bis-(2,2,2-trifluoro-ethylcarbamoyl)-ethoxycarbonylmethyl]-phenyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonylmethyl)-phenyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(2,2-bis-ethylcarbamoyl-2-phenyl-ethoxycarbonylmethyl)-2-chloro-phenyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonylmethyl)-2-chloro-phenyl ester,   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonyl)-phenyl ester, and   4′-trifluoromethyl-biphenyl-2-carboxylic acid 4-(3,3-bis-ethylcarbamoyl-3-phenyl-propoxycarbonyl)-2,6-dichloro-phenyl ester.   
     
     
         30 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 1 , which is selected from the group consisting of
 2-phenyl-2-{2-[4-(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-malonic acid diethyl ester,   2-{2-[3-dimethylcarbamoyl-4-(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-2-phenyl-malonic acid diethyl ester,   2-{2-[3-methoxy-4-(4′-trifluoromethyl-biphenyl-2-carbonyloxy)-phenyl]-acetoxymethyl}-2-phenyl malonic acid diethyl ester, and   4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-benzoic acid 3-[2-(2,2,2-trifluoro-ethylcarbamoyl)-naphthalen-1-yl]-propyl ester.   
     
     
         31 . The ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to  claim 1 , which is selected from the group consisting of
 2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-isopropyl-malonic acid diethyl ester,   2-sec-butyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-isobutyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-propyl-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-ethyl-malonic acid diethyl ester,   2-butyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-allyl-2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-malonic acid diethyl ester,   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxy)-2,2-bis-ethoxycarbonyl-propionic acid ethyl ester, and   2-(2-{3-dimethylcarbamoyl-4-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-acetoxymethyl)-2-(1-methyl-butyl)-malonic acid diethyl ester.   
     
     
         32 . A pharmaceutical composition, which comprises the ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to any of the  claims 1  to  31  and a pharmaceutically acceptable carrier. 
     
     
         33 . An MTP (microsomal triglyceride transfer protein) inhibitor, which comprises the ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to any of  claims 1  to  31  as an active ingredient. 
     
     
         34 . An agent for the treatment or prophylaxis of hyperlipidemia, which comprises the ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to any of  claims 1  to  31  as an active ingredient. 
     
     
         35 . An agent for the treatment or prophylaxis of arteriosclerosis, which comprises the ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to any of  claims 1  to  31  as an active ingredient. 
     
     
         36 . An agent for the treatment or prophylaxis of coronary artery diseases, which comprises the ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to any of  claims 1  to  31  as an active ingredient. 
     
     
         37 . An agent for the treatment or prophylaxis of obesity, which comprises the ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to any of  claims 1  to  31  as an active ingredient. 
     
     
         38 . An agent for the treatment or prophylaxis of diabetes, which comprises the ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to any of  claims 1  to  31  as an active ingredient. 
     
     
         39 . An agent for the treatment or prophylaxis of hypertension, which comprises the ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to any of  claims 1  to  31  as an active ingredient. 
     
     
         40 . An agent for the treatment or prophylaxis of hyperlipidemia, arteriosclerosis, coronary artery diseases, obesity, diabetes or hypertension, which comprises MTP inhibitor selectively inhibiting MTP (microsomal triglyceride transfer protein) in the small intestine and a pharmaceutically acceptable carrier. 
     
     
         41 . The agent for the treatment or prophylaxis according to  claim 40 , wherein the MTP inhibitor does not substantially inhibit MTP in the liver but substantially inhibits only MTP in the small intestine. 
     
     
         42 . The agent for the treatment or prophylaxis according to  claim 41 , wherein after the administered MTP inhibitor inhibits MTP in the small intestine, it is metabolized in the small intestine, blood and liver to the amount at which the remaining MTP inhibitor in the liver does not substantially inhibit the MTP in the liver. 
     
     
         43 . The agent for the treatment or prophylaxis a according to  claim 42 , wherein the remaining MTP inhibitor in the liver is metabolized to the state where TG-releasing activity of the liver is kept at the level of about 80% or more of the normal level. 
     
     
         44 . The agent for the treatment or prophylaxis according to  claims 40  to  43 , wherein the MTP inhibitor is a compound having at least one ester bond. 
     
     
         45 . The agent for the treatment or prophylaxis according to  claim 44 , wherein after the compound having at least one ester bond exerts MTP inhibitory activity, the ester moiety of the compound is metabolized in blood to become an inactive substance. 
     
     
         46 . The agent for the treatment or prophylaxis according to  claims 40  to  45 , wherein the MTP inhibitor is the ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either mentioned in any of  claims 1  to  31 . 
     
     
         47 . A method for the treatment or prophylaxis of hyperlipidemia, arteriosclerosis, coronary artery diseases, obesity, diabetes or hypertension, which comprises administering a compound selectively inhibiting MTP (microsomal triglyceride transfer protein) in the small intestine. 
     
     
         48 . The method according to  claim 47 , wherein after the compound inhibits MTP in the small intestine, it is metabolized in the small intestine, blood and liver to the amount at which remaining said compound in the liver does not substantially inhibit MTP in the liver. 
     
     
         47 . The method according to  claim 47 , wherein the remaining compound in the liver is metabolized to the state where TG-releasing activity of the liver is kept at the level of about 80% or more of the normal level. 
     
     
         50 . The method according to  claims 47  to  49 , wherein the compound has at least one ester bond. 
     
     
         51 . The method according to  claim 50 , wherein after the compound having at least ester bond exerts MTP inhibitory activity, the ester moiety of the compound is metabolized in blood to become an inactive substance. 
     
     
         52 . The method according to  claims 47  to  52 , wherein the compound is the ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either mentioned in any of  claims 1  to  31 . 
     
     
         53 . The agent for the treatment or prophylaxis according to  claims 40  to  46 , wherein the agent is an agent for the treatment or prophylaxis of hyperlipidemia which is used in combination with other antihyperlipidemic drug(s). 
     
     
         54 . The agent for the treatment or prophylaxis according to  claim 53 , wherein other antihyperlipidemic drug is a statin-type drug. 
     
     
         55 . The agent for the treatment or prophylaxis according to  claim 54 , wherein the statin-type drug is one or more drug(s) selected from the group consisting of lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin and cerivastatin. 
     
     
         56 . The agent for the treatment or prophylaxis according to  claims 40  to  46 , wherein the agent is an agent for the treatment or prophylaxis of obesity which is used in combination with other anti-obesity drug(s). 
     
     
         57 . The agent for the treatment or prophylaxis according to  claim 56 , wherein other anti-obesity drug is mazindol or/and orlistat. 
     
     
         58 . The agent for the treatment or prophylaxis according to  claims 40  to  46 , wherein the agent is an agent for the treatment or prophylaxis of diabetes which is used in combination with other anti-diabetic drug(s). 
     
     
         59 . The agent for the treatment or prophylaxis according to  claim 58 , wherein other anti-diabetic drug is one or more drug(s) selected from the group consisting of insulin preparations, sulfonylurea drugs, insulin secretagogues, sulfonamide drugs, biguanide drugs, α-glucosidase inhibitors and insulin resistance-improving drugs. 
     
     
         60 . The agent for the treatment or prophylaxis according to  claim 59 , wherein other anti-diabetic drug is one or more drug(s) selected from the group consisting of insulin, glibenclamide, tolbutamide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metformin hydrochloride, buformin hydrochloride, boglibose, acarbose and pioglitazone hydrochloride. 
     
     
         61 . The agent for the treatment or prophylaxis according to  claims 40  to  46 , wherein the agent is an agent for the treatment or prophylaxis of hypertension which is used in combination with other anti-hypertension drug(s). 
     
     
         62 . The agent for the treatment or prophylaxis according to  claim 61 , wherein other anti-hypertension drug is one or more drug(s) selected from the group consisting of loop diuretics, angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists, calcium antagonists, β-blockers, α,β-blockers and α-blockers. 
     
     
         63 . The agent for the treatment or prophylaxis according to  claim 62 , wherein other anti-hypertension druglis one or more drug(s) selected from the group consisting of furosemide delayed release, captopril, captopril delayed release, enalapril maleate, alacepril, delapril hydrochloride, silazapril, lisinopril, benazepril hydrochloride, imidapril hydrochloride, temocapril hydrochloride, quinapril hydrochloride, trandolapril, perindopril erbumine, losartan potassium, candesartan cilexetil, nicardipine hydrochloride, nicardipine hydrochloride delayed release, nilvadipine, nifedipine, nifedipine delayed release, benidipine hydrochloride, diltiazem hydrochloride, diltiazem hydrochloride delayed release, nisoldipine, nitrendipine, manidipine hydrochloride, barnidipine hydrochloride, efonidipine hydrochloride, amlodipine besylate, felodipine, cilnidipine, aranidipine, propranolol hydrochloride, propranolol hydrochloride delayed release, pindolol, pindolol delayed release, indenolol hydrochloride, carteolol hydrochloride, carteolol hydrochloride delayed release, bunitrolol hydrochloride, bunitrolol hydrochloride delayed release, atenolol, asebutolol hydrochloride, metoprolol tartrate, metoprolol tartrate delayed release, nipradilol, penbutolol sulfate, tilisolol hydrochloride, carvedilol, bisoprolol fumarate, betaxolol hydrochloride, celiprolol hydrochloride, bopindolol malonate, bevantolol hydrochloride, labetalol hydrochloride, arotinolol hydrochloride, amosulalol hydrochloride, prazosin hydrochloride, terazosin hydrochloride, doxazosin mesylate, bunazocin hydrochloride, bunazocin hydrochloride delayed release, urapidil and phentolamine mesylate. 
     
     
         64 . Use of the agent for the treatment or prophylaxis according to  claims 34  to  46  and other antihyperlipidemic drug (s) for the treatment or prophylaxis of hyperlipidemia. 
     
     
         65 . The use according to  claim 64 , wherein other antihyperlipidemic drug is a statin-type drug. 
     
     
         66 . The use according to  claim 64 , wherein the statin-type drug is one or more drug (s) selected from the group consisting of lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin and cerivastatin. 
     
     
         67 . Use of the agent for the treatment or prophylaxis according to  claims 34  to  46  and other anti-obesity drug(s) for the treatment or prophylaxis of obesity. 
     
     
         68 . The use according to  claim 67 , wherein other anti-obesity drug is mazindol or/and orlistat. 
     
     
         69 . Use of the agent for the treatment or prophylaxis according to  claims 34  to  46  and other anti-diabetic drug (s) for the treatment or prophylaxis of diabetes. 
     
     
         70 . The use according to  claim 69 , wherein other anti-diabetic drugs are one or more drug (s) selected from the group consisting of insulin preparations, sulfonylurea drugs, insulin secretagogues, sulfonamide drugs, biguanide drugs, α-glucosidase inhibitors and insulin resistance improving drugs. 
     
     
         71 . The use according to  claim 70 , wherein other anti--diabetic drug is one or more drug(s) selected from the gr l oup consisting of insulin, glibenclamide, tolbutamide, glyclopyramide, acetohexamide, glimepiride, tolazamide, gliclazide, nateglinide, glybuzole, metformin hydrochloide, buformin hydrochloride, boglibose, acarbose and pioglitazone hydrochloride. 
     
     
         72 . Use of the agent for the treatment or prophylaxis according to  claims 34  to  46  and other anti-hypertension drug (s) for the treatment or prophylaxis of hypertension. 
     
     
         73 . The use according to  claim 72 , wherein other anti-hypertension drug is one or more drug (s) selected from the group consisting of loop diuretics, angiotension converting enzyme inhibitors, angiotension II receptor antagonists, calcium antagonists, beta-blockers, alpha/beta blockers and alpha blockers. 
     
     
         74 . The use according to  claim 73 , wherein other anti-hypertension drug is one or more drug (s) selected from the group consisting of furosemide delayed release, captopril, captopril delayed release, enalapril maleate, alacepril, delapril hydrochloride, silazapril, lisinopril, benazepril hydrochloride, imidapril hydrochloride, temocapril hydrochloride, quinapril hydrochloride, trandolapril, perindopril erbumine, losartan potassium, candesartan cilexetil, nicardipine hydrochloride, nicardipine hydrochloride delayed release, nilvadipine, nifedipine, nifedipine delayed release, benidipine hydrochloride, diltiazem hydrochloride, diltiazem hydrochloride delayed release, nisoldipine, nitrendipine, manidipine hydrochloride, barnidipine hydrochloride, efonidipine hydrochloride, amlodipine besylate, felodipine, cilnidipine, aranidipine, propranolol hydrochloride, propranolol hydrochloride delayed release, pindolol, pindolol delayed release, indenolol hydrochloride, carteolol hydrochloride, carteolol hydrochloride delayed release, bunitrolol hydrochloride, bunitrolol hydrochloride delayed release, atenolol, asebutolol hydrochloride, metoprolol tartrate, metoprolol tartrate delayed release, nipradilol, penbutolol sulfate, tilisolol hydrochloride, carvedilol, bisoprolol fumarate, betaxolol hydrochloride, celiprolol hydrochloride, bopindolol malonate, bevantolol hydrochloride, labetalol hydrochloride, arotinolol hydrochloride, amosulalol hydrochloride, prazosin hydrochloride, terazosin hydrochloride, doxazosin mesylate, bunazocin hydrochloride, bunazocin hydrochloride delayed release, urapidil and phentolamine mesylate. 
     
     
         75 . A pharmaceutical composition comprising an effective amount of the ester compound or a prodrug thereof, or a pharmaceutically acceptable salt of either according to any of  claims 1  to  31 , a pharmaceutically acceptable, appropriate amount of ethanol and propylene glycol fatty acid ester. 
     
     
         76 . The pharmaceutical composition according to  claim 75 , which comprises 25 to 35% by weight of ethanol and 65 to 75% by weight of propylene glycol fatty acid ester. 
     
     
         77 . A capsule formulation comprising the pharmaceutical composition according to  claim 75  or  claim 76 . 
     
     
         78 . The capsule formulation according to  claim 77 , wherein the capsule formulation is a hard capsule or soft capsule. 
     
     
         79 . A biphenyl compound represented by the formula (100) 
       
         
           
           
               
               
           
         
       
       wherein
 R 1′  is hydrogen, C 1 -C 6  alkyl, halogen, halo C 1 -C 6  alkyl or C 1 -C 6  alkoxy; 
 R 2′″  is hydrogen, C 1 -C 6  alkyl, halogen, halo C 1 -C 6  alkyl or C 2 -C 6  alkenyl; 
 R 3″  is —CON(R 11a )(R 12a ) wherein R 11a  and R 12a  are each independently hydrogen, C 1 -C 6  alkyl, optionally substituted C 6 -C 14  aryl, optionally substituted C 7 -C 16  aralkyl, C 1 -C 6  alkoxy, or R 11a  and R 12a  may be taken together with the nitrogen to which they are attached to form 
 
       
         
           
           
               
               
           
         
       
       (in which p is an integer of 0 to 2);
 R 4′  is hydrogen, halogen, C 1 -C 6  alkyl or halo C 1 -C 6  alkyl; 
 R 50  is hydrogen, C 1 -C 6  alkyl, optionally substituted C 6 -C 14  aryl or optionally substituted C 7 -C 16  aralkyl; and 
 1a is an integer of 1 to 3, 
 
       or a prodrug thereof, or a pharmaceutically acceptable salt of either. 
     
     
         80 . The biphenyl compound according to  claim 79 , wherein
 R 1′  is hydrogen,   R 2′″  is halo C 1 -C 6  alkyl,   R 3′″  is —CON(R 11b )(R 12b ) wherein R 11b  and R 12b  are each independently hydrogen or C 1 -C 6  alkyl, or R 11b  and R 12b  may be taken together with the nitrogen to which they are attached to form   
       
         
           
           
               
               
           
         
       
       (in which p is an integer of 0 to 2),
 R 4′  is hydrogen, and 
 R 50  is hydrogen or C 1 -C 6  alkyl, 
 
       or a prodrug thereof, or a pharmaceutically acceptable salt of either.
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