Neurologically active compounds

Abstract

The present invention relates to neurologically-active compounds, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, more specifically neurodegenerative conditions such as Alzheimer's disease.

1 .- 34 . (canceled) 
   
   
       35 . A compound of formula Ie: 
     
       
         
         
             
             
         
       
     
     or salts or tautomers thereof in which
 R is O or S; 
 R 1  and R 8  are independently H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heterocyclyl, CN, halo, CF 3 , SO 3 H, OR 2 , SR 2 , SOR 2 , SO 2 R 2 , NR 2 R 3 , (CH 2 ) n NR 2 R 3 , HCNOR 2 , HCNNR 2 R 3 , CONR 2 R 3 , CSNR 2 R 3 , NCOR 2 , NCSR 2 , COR 2 , CO 2 R 2 , CSR 2 , CONH(CH 2 ) 2 R 6  or SO 2 NR 2 R 3  in which R 2  and R 3  are independently selected from H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl and optionally substituted heterocyclyl and n is an integer of 1 to 10; 
 R 6  is optionally substituted heterocycyl; 
 m is an integer from 1 to 3; and 
 q is an integer of 1 or 2, 
 and the optional substituents are C 1-6  alkyl, CF 3 , F, Cl, I, cyano, C 1-6  alkoxy, aryl, heterocyclyl or C 1-6  alkylamino. 
 
   
   
       36 . The compound according to  claim 35  in which R is O. 
   
   
       37 . The compound according to  claim 35  in which R 1  and R 8  are independently halo, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted alkyl, OR 2 , SR 2 , (CH 2 ) n NR 2 R 3 , CONR 2 R 3  or NCOR 2 . 
   
   
       38 . The compound according to  claim 35  in which R 1  and R 8  are independently fluoro, iodo, chloro, optionally substituted phenyl, an optionally substituted unsaturated 3 to 6-membered heteromonocyclic group containing 1 to 4 nitrogen atoms, an optionally substituted saturated 3 to 6-membered heteromonocyclic group containing 1 to 4 nitrogen atoms, an optionally substituted saturated 3 to 6-membered heteromonocyclic group containing 1 to 3 oxygen atoms and 1 to 3 nitrogen atoms, optionally substituted C 1-4 -alkyl, optionally substituted C 2-6 cycloalkyl, optionally substituted C 1-6 alkoxy, optionally substituted thio, CH 2 NR 4 R 5  in which R 4  and R 5  are independently selected from H and C 1-4  alkyl or CONH(CH 2 ) 2 R 6  in which R 6  is optionally substituted heterocyclyl. 
   
   
       39 . The compound according to  claim 35  in which R 8  is located at positions 5 or 7 and R 1  is located at positions 2 or 3. 
   
   
       40 . The compound according to  claim 35  wherein R 1  and R 8  are independently substituted aryl or (CH 2 ) n NR 2 R 3 . 
   
   
       41 . The compound according to  claim 35 , in which the compound of formula I is as follows: 
     
       
         
         
             
             
         
       
     
   
   
       42 . A pharmaceutical or veterinary composition comprising an effective amount of the compound of formula Ie according to  claim 35  and a pharmaceutically or veterinarily acceptable carrier.