US2010160618A1PendingUtilityA1
Expanding the eukaryotic genetic code
Est. expiryApr 17, 2023(expired)· nominal 20-yr term from priority
C12Y 601/0102C12N 15/81C12Y 601/01001A61P 43/00C12N 15/67Y10S435/975C12N 9/93C12Y 601/01Y10S435/81A61K 38/1709C12N 15/00C12N 15/10
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Claims
Abstract
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
Claims
exact text as granted — not AI-modified1 - 135 . (canceled)
136 . A kit for producing a protein that comprises at least one unnatural amino acid in a cell, the kit comprising: a container containing a polynucleotide sequence encoding an O-tRNA, and a polynucleotide sequence encoding an O—RS or an O—RS.
137 . The kit of claim 136 , wherein the kit further comprises at least one unnatural amino acid.
138 . The kit of claim 136 , wherein the kit further comprises instructional materials for producing the protein.Join the waitlist — get patent alerts
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