Resuscitation Fluid

Abstract

The present invention relates to a resuscitation fluid which includes an ionic salt at a concentration above about 0.9%, at least one soluble protein, at least one intermediate energy substrate, and optionally an agent to mitigate intracellular acidosis. Methods of making and using the fluid are also described.

1 - 41 . (canceled) 
   
   
       42 . A resuscitation fluid for treating hypovolemia in a subject, wherein the resuscitation fluid is a solution comprising:
 an ionic salt at a salt concentration between about 0.9% and about 15% by weight of the resuscitation fluid;   a soluble protein at a protein concentration between about 15% and about 40% by weight of the resuscitation fluid;   an intermediate energy substrate at an energy substrate concentration between about 0.1% and about 10% by weight of the resuscitation fluid; and   water.   
   
   
       43 . The resuscitation fluid according to  claim 42  further comprising a buffer. 
   
   
       44 . The resuscitation fluid according to  claim 43 , wherein the resuscitation fluid has a pH adjusted by the buffer to be between about 6.5 and about 7.0. 
   
   
       45 . The resuscitation fluid according to  claim 42 , wherein the ionic salt has a salt concentration between about 5% and about 10% by weight of the resuscitation fluid. 
   
   
       46 . The resuscitation fluid according to  claim 42 , wherein the protein concentration is between about 20% and about 30% by weight of the resuscitation fluid. 
   
   
       47 . The resuscitation fluid according to  claim 42 , wherein the energy substrate concentration is between about 0.5% and about 2% by weight of the resuscitation fluid. 
   
   
       48 . The resuscitation fluid according to  claim 42  further comprising an agent to mitigate intracellular acidosis. 
   
   
       49 . The resuscitation fluid according to  claim 48 , wherein the agent to mitigate intracellular acidosis is present in the resuscitation fluid at an agent concentration between about 0.2% and about 20% by weight of the resuscitation fluid. 
   
   
       50 . The resuscitation fluid according to  claim 48 , wherein the agent concentration is between about 0.5% and about 4% by weight of the resuscitation fluid. 
   
   
       51 . The resuscitation fluid according to  claim 48 , wherein the agent to mitigate intracellular acidosis is N-acetylcysteine. 
   
   
       52 . The resuscitation fluid according to  claim 42 , wherein the soluble protein comprises albumin. 
   
   
       53 . The resuscitation fluid according to  claim 52 , wherein the soluble protein comprises human serum albumin. 
   
   
       54 . The resuscitation fluid according to  claim 42 , wherein the intermediate energy substrate comprises a keto-acid containing a ketone functional group and a carboxylic acid group. 
   
   
       55 . The resuscitation fluid according to  claim 42 , wherein the intermediate energy substrate comprises a carboxylate anion of a keto-acid containing a ketone functional group and a carboxylic acid group. 
   
   
       56 . The resuscitation fluid according to  claim 42 , wherein the intermediate energy substrate comprises pyruvate. 
   
   
       57 . The resuscitation fluid according to  claim 42 , wherein the ionic salt comprises sodium chloride. 
   
   
       58 . A resuscitation fluid for treating hypovolemia in a subject, wherein the resuscitation fluid is a solution comprising;
 an ionic salt;   a soluble protein, wherein the soluble protein comprises albumin;   an intermediate energy substrate, wherein the intermediate energy substrate comprises pyruvate;   an agent to mitigate intracellular acidosis, wherein the agent to mitigate intracellular acidosis comprises N-acetylcysteine; and   water   
   
   
       59 . The resuscitation fluid according to  claim 58  further comprising a buffer, wherein the resuscitation fluid has a pH adjusted by the buffer to be between about 6.5 and about 7.0. 
   
   
       60 . The resuscitation fluid according to  claim 58 , wherein the resuscitation fluid comprises the ionic salt between about 0.9% and about 15% by weight; albumin between about 15% and about 40% by weight; pyruvate between about 0.1% and about 10% by weight; and N-acetylcysteine between about 0.2% and about 20% by weight.