Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines

Abstract

2-Substituted-5-(1-alkylthio)alkylpyridines are produced efficiently and in high yield by cyclization and thioalkylation.

1 . A compound of the formula 
     
       
         
         
             
             
         
       
       wherein 
       R 1  and R 2  independently represent H, C 1 -C 4  alkyl, or R 1  taken together with R 2  represent a 3- to 6-membered saturated ring optionally substituted with an O or a N atom; and 
       R 4  represents C 1 -C 4  haloalkyl. 
     
   
   
       2 . The compound of  claim 1  in which R 4  represents CF 3 . 
   
   
       3 . The compound of  claim 2  in which R 1  represents H and R 2  represents CH 3 . 
   
   
       4 . A compound of the formula 
     
       
         
         
             
             
         
       
       wherein 
       R 1  and R 2  independently represent H, C 1 -C 4  alkyl, or R 1  taken together with R 2  represent a 3- to 6-membered saturated ring optionally substituted with an O or a N atom; and 
       R 4  represents C 1 -C 4  haloalkyl; and 
       X represents Cl or Br. 
     
   
   
       5 . The compound of  claim 4  in which R 4  represents CF 3 . 
   
   
       6 . The compound of  claim 5  in which R 1  represents H and R 2  represents CH 3 .